Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success

开发、展示和传播创新项目以实现转化成功

• 批准号: 9261077
• 负责人: Barry Coller
• 金额: $ 591.18万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-05 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9261077
• 关键词: Adopted; Back; Cessation of life; Clinical; Clinical Nursing Research; Clinical Research; Clinical Sciences; Communities; Conceptions; Data; Databases; Diagnosis; Electronic Health Record; Funding; Genome; Health; Health Policy; Hospitals; Human; Human Resources; Human Subject Research; Institutes; Knowledge; Leadership; Learning; Methods; Multicenter Studies; NCI Scholars Program; New York; Ontology; Outcome; Participant; Perception; Performance; Pharmaceutical Preparations; Phase; Phenotype; Population; Prevention; Protocols documentation; Public Health; Research; Research Personnel; Resources; Science; Scientist; Series; Structure; Testing; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Vision; abstracting; design; experience; human disease; improved; informatics infrastructure; innovation; instrument; member; novel; outreach; programs; repository; skills; success; therapeutic development; volunteer

Contact PD/PI: Coller, Barry The overall vision of the Rockefeller University Center for Clinical and Translational Science (CCTS), supported by the CTSA program, is to develop, demonstrate, and disseminate innovative programs to achieve translational success and to integrate these into a seamless “Learning Clinical Research Enterprise” that uses outcome data to drive quality improvement for the benefit of human health. To achieve this vision we will enhance our existing programs and add new ones. Specific aims: 1. To integrate our existing and new programs into a Translational Research Navigation (TRN) Program that encourages, facilitates, and insures the integrity of all human subjects research from conception to conclusion, and that will expedite our participation in the CTSA network of multi-center studies. 2. To integrate our existing and new programs into a Translational Workforce Educational Program that insures that all members of the translational workforce have the knowledge and skills required for them to perform their functions individually and as members of diverse scientific teams. 3. To integrate our existing and new programs into a From Discovery to Health- Enhancing Product Program to insure that investigators have the resources to maximize the likelihood that they can translate their novel discoveries into products that improve human health. To achieve this vision, we will: 1. Integrate our Community Engaged Navigation, Protocol Navigation, Research Participant Engagement in Protocol Priorities and Design, Basic Scientist Outreach, Mutually Aligned Community Engaged/ Mechanistic Science, Centralized Recruitment and Research Volunteer Repository, Ontology-Backed Phenotyping, and Research Participant Perception programs with a new Protocol Implementation Navigation program into an overarching TRN program under a new administrative structure with senior leadership. TRN will be supported by an integrated Informatics infrastructure adopting best practices and NIH and CTSA data standards. TRN will support both local protocols and CTSA network protocols with TRN leadership serving on the Liaisons to the Trial and Recruitment Innovation Centers. 2. Integrate our extensive current educational programs, including the KL2 Clinical Scholars program, with new educational initiatives to: prepare community clinicians to participate in research teams, enhance Clinical Research Nursing training, provide a full range of educational experiences in translating scientific discoveries into health-enhancing products, develop ontology-backed phenotyping instruments, and query large electronic health record databases to test scientific hypotheses at the population level. 3. Integrate the new Tri-Institutional Therapeutic Development Institute, which provides access to medicinal chemists and drug project management, with the CCTS Pilot program, the Rockefeller scientific resource centers, the New York Genome Center, the new Robertson Therapeutic Development Fund, the TRN program, and the CCTS Hospital to enable investigators to traverse the Valley of Death through Phase 1/2 studies. Outcome metrics will drive performance improvement throughout. Project Summary/Abstract Page 248 Contact PD/PI: Coller, Barry The Rockefeller University Center for Clinical and Translational Science is dedicated to improving human health by providing resources and personnel to support the conduct of the highest quality research to improve the prevention, diagnosis, and treatment of human disease, as well as to inform and implement public health policy. It will also produce novel methods to improve both the scientific information obtained in the studies and the way in which the research is performed.

联系PD/PI：Coller，Barry 洛克菲勒大学临床与转化科学中心（CCTS）的整体愿景， 在CTSA计划的支持下，是开发，演示和传播创新计划以实现 翻译成功，并将其整合到使用的无缝“学习临床研究企业”中 结果数据可推动质量提高，从而受益于人类健康。为了实现这一愿景，我们将 增强我们现有的程序并添加新程序。具体目标：1。整合我们现有和新的 将鼓励，促进和保险的转化研究导航（TRN）计划 从概念到结论的所有人类主体的完整性，这将加快我们的速度 参与多中心研究的CTSA网络。 2。将我们现有的和新程序集成到一个 转化员工教育计划，该计划确保了转化劳动力的所有成员 拥有他们单独执行其职能所需的知识和技能 潜水员科学团队。 3。将我们现有的和新计划整合到从发现到健康中 加强产品计划，以确保调查人员拥有资源以最大化的可能性 他们可以将新颖的发现转化为改善人类健康的产品。为了实现这一愿景，我们 意志：1。整合我们社区参与的导航，协议导航，研究参与者参与 在协议优先级和设计中，基本科学家外展，相互调整的社区参与/机械 科学，集中招聘和研究志愿者存储库，本体支持的表型和 通过新协议实施导航计划的研究参与者的看法计划 总体TRN计划在新的行政结构下具有高级领导。 TRN将得到支持 通过采用最佳实践以及NIH和CTSA数据标准的综合信息学基础架构。 trn Will 通过TRN领导力支持本地协议和CTSA网络协议 试用和招聘创新中心。 2。整合我们广泛的当前教育计划，包括 KL2临床学者计划，并采取了新的教育计划：为社区临床医生做好准备 参加研究团队，增强临床研究护理培训，提供全方位的教育 将科学发现转化为健康增强产品的经验，发展本体论支持 表型工具和查询大型电子健康记录数据库，以测试科学假设 人口水平。 3。整合新的三机构治疗发展研究所 洛克菲勒（Rockefeller 科学资源中心，纽约基因组中心，新罗伯逊治疗发展基金会， TRN计划和CCTS医院，使调查人员能够通过 1/2阶段研究。结果指标将贯穿整个绩效。 项目摘要/摘要页面248 联系PD/PI：Coller，Barry 洛克菲勒大学临床与转化科学中心致力于改善人类 通过提供资源和人员来支持最高质量研究以改善的健康 人类疾病的预防，诊断和治疗以及为公共卫生提供信息 政策。它还将产生新的方法来改善研究中获得的科学信息，并 进行研究的方式。