Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success

联系PD/PI：科勒，巴里 洛克菲勒大学临床与翻译科学中心(CCTS)的总体愿景， 在CTSA计划的支持下，旨在开发、示范和传播创新计划，以实现 翻译成功并将这些整合到一个无缝的“学习型临床研究企业”中，使用 结果数据，以推动质量改进，造福人类健康。为了实现这一愿景，我们将 增强我们现有的计划并添加新的计划。具体目标：1.整合我们现有的和新的 计划纳入翻译研究导航(TRN)计划，鼓励、促进和确保 所有人类研究对象从构思到结论的完整性，这将加快我们的 参加CTSA多中心研究网络。2.将我们现有的和新的计划整合到一个 翻译劳动力教育计划，确保翻译劳动力的所有成员 拥有所需的知识和技能，以履行各自的职能和作为 不同的科学团队。3.将我们现有的和新的计划整合到从发现到健康的过程中- 加强产品计划，以确保调查人员有资源最大限度地提高 他们可以将他们的新发现转化为改善人类健康的产品。为了实现这一愿景，我们 将：1.整合我们的社区参与导航、协议导航、研究参与者参与 在协议优先事项和设计、基础科学家外联、相互协调的社区参与/机制方面 科学，集中招募和研究志愿者储存库，本体支持的表型分析，以及 利用新的协议实施导航计划将参与者感知计划研究为 在高级领导下的新行政结构下的总体TRN计划。将支持TRN 通过采用最佳做法以及NIH和CTSA数据标准的综合信息学基础设施。TRN将 支持本地协议和CTSA网络协议，TRN领导层在与 试验和招聘创新中心。2.整合我们目前广泛的教育计划，包括 KL2临床学者计划，具有新的教育倡议：培养社区临床医生 参与科研团队，加强临床科研护理培训，提供全方位的教育 将科学发现转化为增强健康的产品的经验，开发本体支持的产品 表型仪器，并查询大型电子健康记录数据库，以测试科学假设，网址为 人口水平。3.整合新的三机构治疗发展研究所，该研究所提供 接触药物化学家和药物项目管理，通过CCTS试点计划洛克菲勒 科学资源中心，纽约基因组中心，新的罗伯逊治疗发展基金， TRN计划和CCTS医院使调查人员能够穿越死亡谷 第1/2期研究。结果指标将在整个过程中推动绩效改进。 项目摘要/摘要页248 联系PD/PI：科勒，巴里 洛克菲勒大学临床和翻译科学中心致力于改善人类 通过提供资源和人员支持进行最高质量的研究来改善卫生状况 预防、诊断和治疗人类疾病，以及告知和实施公共卫生 政策。它还将产生新的方法，以改善在研究中获得的科学信息和 进行研究的方式。

Contact PD/PI: Coller, Barry The overall vision of the Rockefeller University Center for Clinical and Translational Science (CCTS), supported by the CTSA program, is to develop, demonstrate, and disseminate innovative programs to achieve translational success and to integrate these into a seamless “Learning Clinical Research Enterprise” that uses outcome data to drive quality improvement for the benefit of human health. To achieve this vision we will enhance our existing programs and add new ones. Specific aims: 1. To integrate our existing and new programs into a Translational Research Navigation (TRN) Program that encourages, facilitates, and insures the integrity of all human subjects research from conception to conclusion, and that will expedite our participation in the CTSA network of multi-center studies. 2. To integrate our existing and new programs into a Translational Workforce Educational Program that insures that all members of the translational workforce have the knowledge and skills required for them to perform their functions individually and as members of diverse scientific teams. 3. To integrate our existing and new programs into a From Discovery to Health- Enhancing Product Program to insure that investigators have the resources to maximize the likelihood that they can translate their novel discoveries into products that improve human health. To achieve this vision, we will: 1. Integrate our Community Engaged Navigation, Protocol Navigation, Research Participant Engagement in Protocol Priorities and Design, Basic Scientist Outreach, Mutually Aligned Community Engaged/ Mechanistic Science, Centralized Recruitment and Research Volunteer Repository, Ontology-Backed Phenotyping, and Research Participant Perception programs with a new Protocol Implementation Navigation program into an overarching TRN program under a new administrative structure with senior leadership. TRN will be supported by an integrated Informatics infrastructure adopting best practices and NIH and CTSA data standards. TRN will support both local protocols and CTSA network protocols with TRN leadership serving on the Liaisons to the Trial and Recruitment Innovation Centers. 2. Integrate our extensive current educational programs, including the KL2 Clinical Scholars program, with new educational initiatives to: prepare community clinicians to participate in research teams, enhance Clinical Research Nursing training, provide a full range of educational experiences in translating scientific discoveries into health-enhancing products, develop ontology-backed phenotyping instruments, and query large electronic health record databases to test scientific hypotheses at the population level. 3. Integrate the new Tri-Institutional Therapeutic Development Institute, which provides access to medicinal chemists and drug project management, with the CCTS Pilot program, the Rockefeller scientific resource centers, the New York Genome Center, the new Robertson Therapeutic Development Fund, the TRN program, and the CCTS Hospital to enable investigators to traverse the Valley of Death through Phase 1/2 studies. Outcome metrics will drive performance improvement throughout. Project Summary/Abstract Page 248 Contact PD/PI: Coller, Barry The Rockefeller University Center for Clinical and Translational Science is dedicated to improving human health by providing resources and personnel to support the conduct of the highest quality research to improve the prevention, diagnosis, and treatment of human disease, as well as to inform and implement public health policy. It will also produce novel methods to improve both the scientific information obtained in the studies and the way in which the research is performed.