Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success

开发、展示和传播创新项目以实现转化成功

• 批准号: 9261077
• 负责人: Barry Coller
• 金额: $ 591.18万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-05 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9261077
• 关键词: Adopted; Back; Cessation of life; Clinical; Clinical Nursing Research; Clinical Research; Clinical Sciences; Communities; Conceptions; Data; Databases; Diagnosis; Electronic Health Record; Funding; Genome; Health; Health Policy; Hospitals; Human; Human Resources; Human Subject Research; Institutes; Knowledge; Leadership; Learning; Methods; Multicenter Studies; NCI Scholars Program; New York; Ontology; Outcome; Participant; Perception; Performance; Pharmaceutical Preparations; Phase; Phenotype; Population; Prevention; Protocols documentation; Public Health; Research; Research Personnel; Resources; Science; Scientist; Series; Structure; Testing; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Vision; abstracting; design; experience; human disease; improved; informatics infrastructure; innovation; instrument; member; novel; outreach; programs; repository; skills; success; therapeutic development; volunteer

Contact PD/PI: Coller, Barry The overall vision of the Rockefeller University Center for Clinical and Translational Science (CCTS), supported by the CTSA program, is to develop, demonstrate, and disseminate innovative programs to achieve translational success and to integrate these into a seamless “Learning Clinical Research Enterprise” that uses outcome data to drive quality improvement for the benefit of human health. To achieve this vision we will enhance our existing programs and add new ones. Specific aims: 1. To integrate our existing and new programs into a Translational Research Navigation (TRN) Program that encourages, facilitates, and insures the integrity of all human subjects research from conception to conclusion, and that will expedite our participation in the CTSA network of multi-center studies. 2. To integrate our existing and new programs into a Translational Workforce Educational Program that insures that all members of the translational workforce have the knowledge and skills required for them to perform their functions individually and as members of diverse scientific teams. 3. To integrate our existing and new programs into a From Discovery to Health- Enhancing Product Program to insure that investigators have the resources to maximize the likelihood that they can translate their novel discoveries into products that improve human health. To achieve this vision, we will: 1. Integrate our Community Engaged Navigation, Protocol Navigation, Research Participant Engagement in Protocol Priorities and Design, Basic Scientist Outreach, Mutually Aligned Community Engaged/ Mechanistic Science, Centralized Recruitment and Research Volunteer Repository, Ontology-Backed Phenotyping, and Research Participant Perception programs with a new Protocol Implementation Navigation program into an overarching TRN program under a new administrative structure with senior leadership. TRN will be supported by an integrated Informatics infrastructure adopting best practices and NIH and CTSA data standards. TRN will support both local protocols and CTSA network protocols with TRN leadership serving on the Liaisons to the Trial and Recruitment Innovation Centers. 2. Integrate our extensive current educational programs, including the KL2 Clinical Scholars program, with new educational initiatives to: prepare community clinicians to participate in research teams, enhance Clinical Research Nursing training, provide a full range of educational experiences in translating scientific discoveries into health-enhancing products, develop ontology-backed phenotyping instruments, and query large electronic health record databases to test scientific hypotheses at the population level. 3. Integrate the new Tri-Institutional Therapeutic Development Institute, which provides access to medicinal chemists and drug project management, with the CCTS Pilot program, the Rockefeller scientific resource centers, the New York Genome Center, the new Robertson Therapeutic Development Fund, the TRN program, and the CCTS Hospital to enable investigators to traverse the Valley of Death through Phase 1/2 studies. Outcome metrics will drive performance improvement throughout. Project Summary/Abstract Page 248 Contact PD/PI: Coller, Barry The Rockefeller University Center for Clinical and Translational Science is dedicated to improving human health by providing resources and personnel to support the conduct of the highest quality research to improve the prevention, diagnosis, and treatment of human disease, as well as to inform and implement public health policy. It will also produce novel methods to improve both the scientific information obtained in the studies and the way in which the research is performed.

联系人 PD/PI：Coller, Barry 洛克菲勒大学临床与转化科学中心（CCTS）的总体愿景， 在 CTSA 计划的支持下，旨在开发、展示和传播创新计划，以实现 转化成功并将其整合到一个无缝的“学习临床研究企业”中，该企业使用 结果数据推动质量改进，造福人类健康。为了实现这一愿景，我们将 增强我们现有的计划并添加新的计划。具体目标： 1. 整合我们现有的和新的 转化研究导航 (TRN) 计划，鼓励、促进和确保 所有人类受试者研究从概念到结论的完整性，这将加快我们的进程 参与 CTSA 多中心研究网络。 2. 将我们现有的和新的计划整合到一个 转化劳动力教育计划，确保转化劳动力的所有成员 拥有单独和作为成员履行职责所需的知识和技能 多元化的科学团队。 3. 将我们现有的和新的计划整合到“从发现到健康”中- 加强产品计划，以确保调查人员拥有资源来最大限度地提高以下可能性： 他们可以将新发现转化为改善人类健康的产品。为了实现这一愿景，我们 将： 1. 整合我们的社区参与导航、协议导航、研究参与者参与 协议优先级和设计、基础科学家外展、相互协调的社区参与/机制 科学、集中招募和研究志愿者存储库、本体支持的表型分析以及 研究参与者感知计划与新的协议实施导航计划 在由高级领导层领导的新行政结构下实施总体 TRN 计划。将支持 TRN 通过采用最佳实践以及 NIH 和 CTSA 数据标准的集成信息学基础设施。 TRN 将 支持本地协议和 CTSA 网络协议，TRN 领导层负责联络 试用和招聘创新中心。 2. 整合我们当前广泛的教育计划，包括 KL2 临床学者计划，其新的教育举措旨在： 让社区临床医生做好准备 参与研究团队，加强临床研究护理培训，提供全方位的教育 将科学发现转化为增强健康的产品、开发本体论支持的经验 表型分析仪器，并查询大型电子健康记录数据库以测试科学假设 人口水平。 3. 整合新的三机构治疗发展研究所，该研究所提供 通过 CCTS 试点计划、洛克菲勒项目，接触药物化学家和药物项目管理 科学资源中心、纽约基因组中心、新罗伯逊治疗发展基金、 TRN 计划和 CCTS 医院使调查人员能够穿越死亡之谷 1/2 期研究。结果指标将推动整个绩效的提高。 项目总结/摘要第 248 页 联系人 PD/PI：Coller, Barry 洛克菲勒大学临床和转化科学中心致力于改善人类健康 通过提供资源和人员支持进行最高质量的研究来改善健康状况 人类疾病的预防、诊断和治疗，以及告知和实施公共卫生 政策。它还将产生新的方法来改进研究中获得的科学信息和 研究进行的方式。