TRANSFORMING TRANSLATIONAL SCIENCE AND EDUCATION TO BENEFIT HUMAN HEALTH

转变转化科学和教育以造福人类健康

• 批准号: 8365034
• 负责人: Barry Coller
• 金额: $ 247.6万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365034
• 关键词: Health; Human; Translational Research; science education

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The goal of The Rockefeller University Center for Clinical and Translational Science is to improve human health by: 1. providing an infrastructure to conduct clinical investigation at the highest level, educational programs to train future generations of skilled and committed investigators, and novel methods of clinical investigation that can be shared with others, and 2. working closely with other CTSA institutions to set national standards so as to improve the conduct of clinical research. The 2006 Clinical and Translational Science Award transformed translational research at Rockefeller University and we propose to build on these accomplishments by: 1) enhancing our KL2 Master's degree and Certificate in Clinical and Translational Science educational programs; 2) creating a new educational program for our current K08 and K23 awardees to speed their transition to scientific independence; 3) expanding our bidirectional community engaged research with our partner institutions, integrating molecular mechanistic and population-based components, 4) completing the implementation of our integrated, customized information technology infrastructure to facilitate protocol development, review, and conduct; 5) implementing a novel real-time monitoring system to insure compliance with Good Clinical Practice; 6) enhancing our multi-disciplinary and multi-departmental Protocol Navigation program to speed protocol development, approval, and implementation, and extending it to bidirectional community engaged research; 7) expanding the application of novel nonparametric biostatistical methods to genomic and community-based investigation; 8) utilizing our new deep human phenotyping systems to aid scientific discovery and address important clinical needs; 9) utilizing a validated measure of research participants' perceptions to improve the conduct of clinical research; and 10) continuing to actively participate in the national CTSA consortium to advance the discipline of clinical and translational science for the benefit of human health. PUBLIC HEALTH RELEVANCE (provided by applicant): The Rockefeller University Center for Clinical and Translational Science is dedicated to improving human health by providing the resources and personnel to conduct the highest quality research to improve the prevention, diagnosis, and treatment of human disease. It also is producing novel methods to improve the scientific information obtained from clinical research studies and the way in which the research is performed.

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 描述(由申请人提供)：洛克菲勒大学临床与翻译科学中心的目标是通过以下方式改善人类健康：1.提供进行最高水平临床研究的基础设施、培养下一代熟练且尽职尽责的研究人员的教育计划，以及可与他人共享的新的临床研究方法，以及2.与其他CTSA机构密切合作，制定国家标准，从而改善临床研究的进行。2006年的临床和转化科学奖改变了洛克菲勒大学的转化研究，我们建议通过以下方式进一步发展这些成就：1)提高我们的临床和转化科学教育项目的KL2硕士学位和证书；2)为我们现有的K08和K23获奖者创建一个新的教育项目，以加速他们向科学独立的过渡；3)扩大我们与合作机构的双向社区参与研究，整合分子力学和基于人群的组件；4)完成我们集成的、定制的信息技术基础设施的实施，以促进方案的开发、审查和实施；5)实施新的实时监测系统，以确保符合良好的临床实践；6)加强我们的多学科和多部门的协议导航计划，以加快协议的开发、批准和实施，并将其扩展到双向社区参与研究；7)将新型非参数生物统计学方法的应用扩展到基因组和基于社区的研究；8)利用我们新的深度人类表型系统来帮助科学发现和满足重要的临床需求；9)利用研究参与者感知的有效措施来改进临床研究的进行；以及10)继续积极参与国家CTSA联盟，以促进临床和翻译科学的学科，以造福人类健康。 公共卫生相关性(由申请者提供)：洛克菲勒大学临床和转化科学中心致力于通过提供资源和人员来开展最高质量的研究，以改善人类疾病的预防、诊断和治疗，从而改善人类健康。它还在创造新的方法来改进从临床研究中获得的科学信息和进行研究的方式。