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Telomere Length as a Mediator Between Early Life Stress and Child Health Outcomes

端粒长度作为早期生活压力和儿童健康结果之间的中介

基本信息

批准号：
9404640
负责人：
Kathryn Leigh Humphreys
金额：
$ 0.06万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-07 至 2018-08-08
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9404640
关键词：
Adolescence Adult Adverse event Affective Aging American Psychiatric Association Apoptosis Biological Biological Aging Biological Markers Cell Aging Cells Characteristics Child Child Abuse and Neglect Child health care Childhood Chronic Clinical Cognitive Depressed mood Development Disease Disease Progression Epigenetic Process Exposure to Health Hydrocortisone Impairment Individual Knowledge Length Life Life Experience Life Stress Light Link Measures Mediating Mediator of activation protein Mental Depression Mental Health Mental disorders Modeling Nature Onset of illness Outcome Psychopathology Recording of previous events Research Personnel Risk Role Sampling Sex Characteristics Social Conditions Stress Symptoms System Telomere Shortening Testing Time Violence abuse neglect biological adaptation to stress boys early experience epigenetic marker experience follow up assessment follow-up girls global health insight maltreated children mental development physical conditioning prepuberty prospective public health relevance response social deprivation telomere

项目摘要

DESCRIPTION (provided by applicant): Early life stress (ELS), including abuse, neglect, and loss, is associated with dramatic increases in lifelong risk for the development of mental and physical health difficulties. The mechanisms through which ELS confers risk for these negative outcomes, however, are not well understood. Stressful life experiences activate the stress response systems, and high levels of stress have been linked to telomere shortening, an epigenetic marker of aging. Thus, shorter telomere length may be one mechanism through which ELS leads to negative health outcomes later in life. In the proposed study we will examine the association of ELS with a measure of cellular aging, as well as with measures of mental and physical health during childhood. More specifically, we will examine in a large sample of pre-pubertal boys and girls the association between ELS and telomere length, as well as rate of telomere attrition across the pubertal period as a function of early experiences of stress. We will also examine the link between ELS and irritability, a common characteristic of several psychiatric disorders, that has been associated with more severe and chronic forms of mental health difficulties. In addition, we also will examine the association between ELS and physical health, given that global measures of health in childhood are likely to precede the onset of specific diseases of aging in adulthood. Finally, we will examine the degree to which variability in telomere length explains increased irritability and physical health problems in individuals with a history of ELS, in order to test a potential mechanism by which early adverse experiences result in maladaptive outcomes. The results of this study will not only increase our understanding of the relations among ELS, telomere length, and health outcomes, but will also provide insight into a markers of cellular aging longitudinally during the important developmental period of adolescence, a stage of increased risk for the onset of mental health difficulties following ELS. Thus, we anticipate that the current study will contribute to our understanding both of models of the onset of psychopathology following ELS and of mechanisms by which ELS confers heightened risk for negative health outcomes. Findings from the proposed study will increase our knowledge of biological responses to stress and will provide insight into the onset and progression of disease following early adversity.

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cerebral blood flow in 5- to 8-month-olds: Regional tissue maturity is associated with infant affect.

DOI：
10.1111/desc.12928
发表时间：
2020-09
期刊：
Developmental science
影响因子：
3.7
作者：
Catalina Camacho M;King LS;Ojha A;Garcia CM;Sisk LM;Cichocki AC;Humphreys KL;Gotlib IH
通讯作者：
Gotlib IH

Self-reported neglect, amygdala volume, and symptoms of anxiety in adolescent boys.