High-speed Intraoperative Assessment of Breast Tumor Margin using MarginPAT

使用 MarginPAT 高速术中评估乳腺肿瘤边缘

基本信息

  • 批准号:
    9443729
  • 负责人:
  • 金额:
    $ 5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-08-25 至 2017-08-24
  • 项目状态:
    已结题

项目摘要

After a breast conserving therapy, histology is often performed to check whether the excised tumor specimen is surrounded by a sufficient amount of normal tissue. If a positive margin is identified, then a second operation will be performed. Currently, the re-operation rate is 20-40%, which raises a need for intraoperative detection of residual cancers. The current intraoperative tools for margin assessment are time consuming and lack sufficient tumor specificity. Multiple emerging optical technologies improved the sensitivity and specificity but still suffered from a long procedure time. We propose a multi-modal spectroscopic photoacoustic/ultrasound imaging system to differentiate cancer and normal tissue in a resected breast tissue. Providing both chemical content and mechanical property information, this system, named MarginPAT, is able to measure map tissue components including blood, fat, fibrosis tissue, and breast lesion. Based on a compact Raman laser and a high-speed scanning chamber, the proposed MarginPAT system is able to scan 10 cm2 tissue area per min, which is faster than the frozen section analysis (gold standard for intraoperative assessment) by one order of magnitude. Such capacities allow 3 dimensional assessment of margin status in the entire excised tissue with >90% sensitivity and specificity.
在保乳治疗后,通常进行组织学检查,以检查是否 切除的肿瘤样本被足够量的正常组织包围。 如果识别出正裕度,则将执行第二操作。 目前,再手术率为20- 40%,这就需要术中 检测残留的癌症。目前用于切缘的术中工具 评估是耗时的并且缺乏足够的肿瘤特异性。多 新兴的光学技术提高了灵敏度和特异性, 手术时间很长我们提出了一个多模式光谱 用于区分癌症和正常组织的光声/超声成像系统 在切除的乳房组织中。提供化学成分和机械成分 属性信息,该系统,命名为MarginPAT,能够测量地图 组织成分,包括血液、脂肪、纤维化组织和乳腺病变。基于 在小型拉曼激光器和高速扫描室上, MarginPAT系统能够每分钟扫描10 cm 2的组织面积,比 冷冻切片分析(术中评估的金标准) 数量级。这种能力允许对保证金进行三维评估 整个切除组织的状态,灵敏度和特异性>90%。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
High-speed Intraoperative Assessment of Breast Tumor Margins by Multimodal Ultrasound and Photoacoustic Tomography.
  • DOI:
    10.1002/mds3.10018
  • 发表时间:
    2018-06-01
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Li, Rui;Lan, Lu;Cheng, Ji-Xin
  • 通讯作者:
    Cheng, Ji-Xin
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Ji-Xin Cheng其他文献

Ji-Xin Cheng的其他文献

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{{ truncateString('Ji-Xin Cheng', 18)}}的其他基金

2023 Chemical Imaging Gordon Research Conferences
2023 年化学成像戈登研究会议
  • 批准号:
    10605394
  • 财政年份:
    2023
  • 资助金额:
    $ 5万
  • 项目类别:
Sub-millimeter precision wireless neuromodulation using a microwave split ring resonator
使用微波开口环谐振器的亚毫米精度无线神经调节
  • 批准号:
    10669784
  • 财政年份:
    2022
  • 资助金额:
    $ 5万
  • 项目类别:
High-content High-speed Chemical Imaging of Metabolic Reprogramming by Integration of Advanced Instrumentation and Data Science
通过先进仪器和数据科学的集成进行代谢重编程的高内涵高速化学成像
  • 批准号:
    10543185
  • 财政年份:
    2022
  • 资助金额:
    $ 5万
  • 项目类别:
High-content High-speed Chemical Imaging of Metabolic Reprogramming by Integration of Advanced Instrumentation and Data Science
通过先进仪器和数据科学的集成进行代谢重编程的高内涵高速化学成像
  • 批准号:
    10344774
  • 财政年份:
    2022
  • 资助金额:
    $ 5万
  • 项目类别:
Sub-millimeter precision wireless neuromodulation using a microwave split ring resonator
使用微波开口环谐振器的亚毫米精度无线神经调节
  • 批准号:
    10516429
  • 财政年份:
    2022
  • 资助金额:
    $ 5万
  • 项目类别:
Mapping Cancer Metabolism by Mid-infrared Photothermal Microscopy
通过中红外光热显微镜绘制癌症代谢图
  • 批准号:
    10491322
  • 财政年份:
    2021
  • 资助金额:
    $ 5万
  • 项目类别:
Mapping Cancer Metabolism by Mid-infrared Photothermal Microscopy
通过中红外光热显微镜绘制癌症代谢图
  • 批准号:
    10271761
  • 财政年份:
    2021
  • 资助金额:
    $ 5万
  • 项目类别:
Mapping Cancer Metabolism by Mid-infrared Photothermal Microscopy
通过中红外光热显微镜绘制癌症代谢图
  • 批准号:
    10675665
  • 财政年份:
    2021
  • 资助金额:
    $ 5万
  • 项目类别:
Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living Systems
振动光谱成像揭示生命系统中隐藏的特征
  • 批准号:
    10206200
  • 财政年份:
    2020
  • 资助金额:
    $ 5万
  • 项目类别:
Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living Systems
振动光谱成像揭示生命系统中隐藏的特征
  • 批准号:
    10660979
  • 财政年份:
    2020
  • 资助金额:
    $ 5万
  • 项目类别:

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