权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Stanford and Northrop Grumman proposal for the Oncology Models Forum

斯坦福大学和诺斯罗普·格鲁曼公司关于肿瘤模型论坛的提案

基本信息

批准号：
9320530
负责人：
ATUL J BUTTE
金额：
$ 94.1万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9320530
关键词：
Address Area Award Bioinformatics Cancer Model Catalogs Communicable Diseases Communities Community Clinical Oncology Program Credentialing Data Data Analyses Databases Development Diagnostic Disease model Educational workshop Ensure Feedback Funding Funding Mechanisms Future Genetically Engineered Mouse Goals Hour Human Hypersensitivity Immunology Inbred Mouse Institutes Knowledge Learning Malignant Neoplasms Manuscripts Maryland Mission Modeling Mus NIH Program Announcements Nanotechnology National Cancer Institute Nature Online Systems Output Participant Published Comment Publishing Research Research Personnel Resources Role Science Services Site Software Engineering Structure Support Contracts Technology Therapeutic Translations Transplantation Universities Validation Xenograft procedure biomedical informatics biomedical ontology community building data modeling data sharing design experience human data innovation knowledge base meetings mouse model oncology open source pre-clinical programs public health relevance skills software development success support network technology development tool translational cancer research tumor web site

项目摘要

DESCRIPTION (provided by applicant): The mission for the Oncology Models Forum (OMF) is to align, harness and integrate data and knowledge of cancer mouse models to drive more rapid success in the discovery of diagnostics, therapeutics, and models of disease in cancer. In early June 2014, the National Cancer Institute (NCI) released PAR-14-239 describing the OMF as a "comprehensive resource for information to guide generating, validating, and credentialing new models, informing their practical uses, advancing modeling technologies, [and] providing catalogs of available models resources, programs, and services." To maximize the use of available resources, this online site was prescribed to use HUBzero, an existing open-source scientific website framework, avoiding the expensive creation of a new scientific website from scratch. The OMF was designed as a community-building tool, with online discussion forums and an annual meeting. Specific content will be provided from the collaborative R01s funded in parallel to the OMF. Pre-clinical mouse and human-in-mouse models are critical to future translation in cancer. More than 4,300 manuscripts were published in 2013 describing or using cancer mouse models, including xenografts and transplantation models, spontaneous models, inbred mice, and genetically engineered mouse models (GEMM). The NCI Cancer Models Database (caMOD) now lists thousands of mouse models that are prone to develop tumors in one or more sites. But data on these models is scattered across numerous resources. Future success in research using cancer mouse models is now less dependent on the continued creation of new models, and more dependent on the validation of the thousands of currently available models, transparent access to knowledge and data on these models, comparisons of model data with human data, and organization of the research community. We plan to develop the Oncology Models Forum (OMF) to accomplish these goals. Our proposed OMF will integrate structured and unstructured data and knowledge on cancer mouse models, enabling new discoveries and the development of new translational tools.