Stanford and Northrop Grumman proposal for the Oncology Models Forum

斯坦福大学和诺斯罗普·格鲁曼公司关于肿瘤模型论坛的提案

• 批准号: 9762589
• 负责人: ATUL J BUTTE
• 金额: $ 91.28万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762589
• 关键词: Address; Area; Award; Bioinformatics; Cancer Model; Catalogs; Communicable Diseases; Communities; Community Clinical Oncology Program; Credentialing; Data; Data Analyses; Databases; Diagnostic; Disease model; Educational workshop; Ensure; Feedback; Funding; Funding Mechanisms; Future; Genetically Engineered Mouse; Goals; Hour; Human; Hypersensitivity; Immunology; Inbred Mouse; Institutes; Knowledge; Learning; Malignant Neoplasms; Manuscripts; Maryland; Mission; Modeling; Mus; NIH Program Announcements; Nanotechnology; National Cancer Institute; Nature; Online Systems; Output; Participant; Published Comment; Publishing; Research; Research Personnel; Resources; Role; Science; Services; Site; Software Engineering; Structure; Support Contracts; Technology; Therapeutic; Translations; Universities; Validation; Xenograft procedure; biomedical informatics; biomedical ontology; community building; data modeling; data sharing; design; experience; human data; innovation; knowledge base; meetings; mouse model; oncology; open source; pre-clinical; programs; public health relevance; skills; software development; success; support network; technology development; tool; translational cancer research; transplant model; tumor; web site; webinar

 DESCRIPTION (provided by applicant): The mission for the Oncology Models Forum (OMF) is to align, harness and integrate data and knowledge of cancer mouse models to drive more rapid success in the discovery of diagnostics, therapeutics, and models of disease in cancer. In early June 2014, the National Cancer Institute (NCI) released PAR-14-239 describing the OMF as a "comprehensive resource for information to guide generating, validating, and credentialing new models, informing their practical uses, advancing modeling technologies, [and] providing catalogs of available models resources, programs, and services." To maximize the use of available resources, this online site was prescribed to use HUBzero, an existing open-source scientific website framework, avoiding the expensive creation of a new scientific website from scratch. The OMF was designed as a community-building tool, with online discussion forums and an annual meeting. Specific content will be provided from the collaborative R01s funded in parallel to the OMF. Pre-clinical mouse and human-in-mouse models are critical to future translation in cancer. More than 4,300 manuscripts were published in 2013 describing or using cancer mouse models, including xenografts and transplantation models, spontaneous models, inbred mice, and genetically engineered mouse models (GEMM). The NCI Cancer Models Database (caMOD) now lists thousands of mouse models that are prone to develop tumors in one or more sites. But data on these models is scattered across numerous resources. Future success in research using cancer mouse models is now less dependent on the continued creation of new models, and more dependent on the validation of the thousands of currently available models, transparent access to knowledge and data on these models, comparisons of model data with human data, and organization of the research community. We plan to develop the Oncology Models Forum (OMF) to accomplish these goals. Our proposed OMF will integrate structured and unstructured data and knowledge on cancer mouse models, enabling new discoveries and the development of new translational tools.

 描述（由申请人提供）：肿瘤学模型论坛（OMF）的使命是调整、利用和整合癌症小鼠模型的数据和知识，以推动在发现癌症疾病的诊断、治疗和模型方面取得更快的成功。2014年6月初，美国国家癌症研究所（NCI）发布了PAR-14-239，将OMF描述为“指导生成、验证和认证新模型的综合信息资源，告知其实际用途，推进建模技术，[并]提供可用模型资源、程序和服务的目录。“为了最大限度地利用现有资源，该在线网站被规定使用HUBzero，这是一个现有的开源科学网站框架，避免了从头开始创建一个新的科学网站的昂贵费用。OMF被设计为一个社区建设工具，设有在线讨论论坛和年度会议。具体内容将由与OMF同时资助的合作R 01提供。临床前小鼠和人鼠模型对于癌症的未来转化至关重要。2013年发表了4,300多篇描述或使用癌症小鼠模型的论文，包括异种移植和移植模型、自发模型、近交系小鼠和遗传工程小鼠模型（GEMM）。NCI癌症模型数据库（caMOD）现在列出了数千种易于在一个或多个部位发生肿瘤的小鼠模型。但这些模型的数据分散在许多资源中。使用癌症小鼠模型的研究未来的成功现在较少依赖于新模型的持续创建，而更多地依赖于对数千个现有模型的验证，透明地获取这些模型的知识和数据，将模型数据与人类数据进行比较，以及研究社区的组织。我们计划开发肿瘤模型论坛（OMF）来实现这些目标。我们提出的OMF将整合癌症小鼠模型的结构化和非结构化数据和知识，从而实现新的发现和新的翻译工具的开发。

项目成果

Do Cancer Clinical Trial Populations Truly Represent Cancer Patients? A Comparison of Open Clinical Trials to the Cancer Genome Atlas

癌症临床试验人群是否真正代表癌症患者？

• DOI: 10.1142/9789814749411_0029
• 发表时间: 2016
• 期刊: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
• 作者: N. Geifman;A. Butte
• 通讯作者: A. Butte

Widespread parainflammation in human cancer.

人类癌症中广泛的副炎症。

• DOI: 10.1186/s13059-016-0995-z
• 发表时间: 2016-07-08
• 期刊: Genome biology
• 影响因子: 12.3
• 作者: Aran D;Lasry A;Zinger A;Biton M;Pikarsky E;Hellman A;Butte AJ;Ben-Neriah Y
• 通讯作者: Ben-Neriah Y

Future cancer research priorities in the USA: a Lancet Oncology Commission.

• DOI: 10.1016/s1470-2045(17)30698-8
• 发表时间: 2017-11
• 期刊: The Lancet. Oncology
• 作者: Jaffee EM;Dang CV;Agus DB;Alexander BM;Anderson KC;Ashworth A;Barker AD;Bastani R;Bhatia S;Bluestone JA;Brawley O;Butte AJ;Coit DG;Davidson NE;Davis M;DePinho RA;Diasio RB;Draetta G;Frazier AL;Futreal A;Gambhir SS;Ganz PA;Garraway L;Gerson S;Gupta S;Heath J;Hoffman RI;Hudis C;Hughes-Halbert C;Ibrahim R;Jadvar H;Kavanagh B;Kittles R;Le QT;Lippman SM;Mankoff D;Mardis ER;Mayer DK;McMasters K;Meropol NJ;Mitchell B;Naredi P;Ornish D;Pawlik TM;Peppercorn J;Pomper MG;Raghavan D;Ritchie C;Schwarz SW;Sullivan R;Wahl R;Wolchok JD;Wong SL;Yung A
• 通讯作者: Yung A

A patient-level data meta-analysis of standard-of-care treatments from eight prostate cancer clinical trials.

• DOI: 10.1038/sdata.2016.27
• 发表时间: 2016-05-10
• 期刊: Scientific data
• 影响因子: 9.8
• 作者: Geifman N;Butte AJ
• 通讯作者: Butte AJ

Cancer Cell-Autonomous Parainflammation Mimics Immune Cell Infiltration.

• DOI: 10.1158/0008-5472.can-16-3383
• 发表时间: 2017-07-15
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Lasry A;Aran D;Butte AJ;Ben-Neriah Y
• 通讯作者: Ben-Neriah Y