Multi Source E-Beam kV X-Ray Tube for Image-Guided Radiotheraphy

用于图像引导放射治疗的多源电子束 kV X 射线管

• 批准号: 9750326
• 负责人: DOUGLAS P BOYD
• 金额: $ 21.82万
• 依托单位: IMATREX INC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2018-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9750326
• 关键词: Multi; Source; Beam; kV; Ray

 DESCRIPTION (provided by applicant): This project will develop a commercial product that will enable for the first time realtime tumor tracking during radiotherapy at an attractive price point and with minimal interference with standard clinical practice. The key novel technology is an optimized multi-source X-ray tube with 19 focal spots that is placed below the multi-leaf collimator (MLC) of a radiotherapy system as shown below. By steering a focused electron beam (e-beam) on a series of 19 cooled tungsten targets in sequence, this system will provide a set of projection images that can be reconstructed into a 20 cm × 20 cm × 20 cm digital tomosynthesis (DTS) volume image that surrounds the radiation target. The projection X-rays are captured by a universal kV-MV imager that can record portal MV images interlaced with the sequence of tomographic kV images. Since the sources are positioned around the perimeter of the MLC, the resulting tomographic cross section images are aligned perpendicular to the axis of the therapy beam. This geometry is referred to as "Beam's Eye View" imaging. The DTS images will be used to provide precise reference coordinates of a tumor surface for programming of the MLC, in near real-time. The preliminary specifications for the system indicate that a repetition rate of 2-3 volume images per second with near 1 mm spatial resolution will be possible. The multi-source e-beam X-ray tube will be developed by substantially the same premier team who developed the original Imatron EBCT scanners and the more recent e-beam luggage scanner. The e-beam team consisting of TeleSecurity Sciences, Inc. scientists, consultants, and vendors has partnered with the premier cone beam CT team at UC Davis along with a key Varian consultant, who are authorities on flat panel X-ray imagers, and in particular the Side-view of the TumoTrakTM in a Truebeam gantry kV-MV imager that will be used in this project to provide simultaneous MV portal imaging with interlaced kV DTS imaging of the tumor position. Phase 1 of the project extended the preliminary work to more precisely define the final design specifications for a future commercial system that will be appropriate for the entire radiotherapy industry. Phase 2 funding will develop a suitable prototype of the multi-source eBeam X-ray tube which will demonstrate the feasibility and performance of the commercial system. The majority of radiotherapy vendors have provided guidance and letters of support for this project. The commercial implementation of the proposed system in future radiotherapy systems will permit treatment plans that will have far improved localization of radiation exposure within reduced margins beyond the apparent boundaries of a malignant mass with a corresponding reduction in exposure to surrounding normal structures. This will be especially important in treating tumors of the chest and upper abdomen during free breathing where periodic motion in the range of 2 cm to 5 cm is often encountered.



项目成果

Dosimetry of a novel converging X-ray source for kilovoltage radiotherapy.

• DOI: 10.1002/mp.15167
• 发表时间: 2021-10
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Stalbaum T;Partain L;Weil MD;Kim J;Han JY;Plies MJ;Chen H;Ziskin V;Bazalova-Carter M;Song S;Rand R;Boyd D
• 通讯作者: Boyd D