Juvenile Protective Factors and Their Effects on Aging

青少年保护因素及其对衰老的影响

• 批准号: 9330041
• 负责人: SHUMEI S SUN
• 金额: $ 35.9万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9330041
• 关键词: Address; Adolescence; Adolescent; Adult; Affect; Age; Age of Onset; Aging; Birth; Blood Circulation; Cardiovascular Diseases; Caring; Child; Childhood; Clinical assessments; Data Set; Databases; Diastolic blood pressure; Disease; Dyslipidemias; Fasting; Fatty acid glycerol esters; Female; Future; Goals; Health; High Density Lipoprotein Cholesterol; High Density Lipoproteins; Hypertension; Impaired fasting glycaemia; Incidence; Individual; Insulin-Like Growth-Factor Binding Protein 1; Intervention; Lead; Life Style; Literature; Logistics; Longevity; Longitudinal Studies; Malignant Neoplasms; Measurement; Mediating; Mediation; Medical; Metabolic syndrome; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Osteocalcin; Osteoporosis; Participant; Pharmacology; Plasma; Prevalence; Prevention; Preventive; Public Health; Research; Risk; Risk Factors; Sampling; Source; Therapeutic; Time; adiponectin; age related; base; cost; delay sexual debut; early onset; healthy aging; human capital; human very old age (85+); insulin sensitivity; male; novel; novel therapeutics; osteoporosis with pathological fracture; public health relevance; sex; sexual dimorphism

 DESCRIPTION (provided by applicant): We plan to analyze the data set generated by 2567 participants in the Fels Longitudinal Study over a period of eight decades in order to ascertain if certain putative juvenile protective factors and juvenile protective states can delay the onset of age related disease (ARD) and increase longevity in subjects who retain juvenile levels of such protective factors and states in adulthood. Although it is possible to age in good health, obesity, hypertension (HBP), dyslipidemia, and impaired fasting glucose are frequent concomitants of aging, as well as type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), cancer, and osteoporosis (OP). These conditions all increase in prevalence with age, and age is the primary risk factor for cancer, CVD, and osteoporotic fractures. The putative JPF we plan to study are adiponectin, osteocalcin, and insulin-like growth factor-1 binding protein 3 (IGF1BP3). There is evidence in the literature that these putative JPF are associated with either enhanced survival and/or a delay in the onset of ARD. A defining attribute of a JPF is that it could theoretically be replenished from exogenous sources to re-establish juvenile levels in the circulation in order to engender a delay in the onset of ARD or even to reverse established ARD. Unlike JPF, JPS could not be added to the circulation from exogenous sources. However, significant changes in JPS can be attained by life-style and/or pharmacologic means. Therefore, we will examine the effects of persistence of juvenile levels of these protective states in FLS adult participants on te onset of ARD. The putative JPS we plan to study include high fat-free mass/ht2 (FFM/ht2), high insulin sensitivity high HDL- cholesterol, and low systolic and/or diastolic blood pressure (SBP/DBP. Should we confirm that some or all of these JPF and JPS are associated with a delayed onset of ARD and/or with an extended life span, our findings may be applied in clinical assessments of individuals whose JPF and JPS trajectories diverge from those that predict delayed onset of ARD. It may also be possible to develop novel therapies based on maintaining or restoring juvenile levels of these protective factors and states in adulthood to delay the onset of ARD or reverse established ARD. We recognize that major logistic and regulatory hurdles must be cleared before such novel preventive or therapeutic approaches can be applied.

 描述（由适用提供）：我们计划分析在长达八十年的时间里，由2567名FELS纵向研究的参与者生成的数据集，以确定是否是否 某些推定的少年保护因素和少年保护状态可以延迟与年龄相关疾病（ARD）的发作，并增加保留此类受保护因素和成年状态的少年水平的受试者的寿命。虽然有可能身体健康，肥胖症，但 高血压（HBP），血脂异常和禁食葡萄糖受损通常是衰老的伴随，以及2型糖尿病（T2DM），心血管疾病（CVD），癌症和骨质疏松症（OP）。这些疾病的患病率随着年龄的增长而增加，而年龄是癌症，CVD和骨质疏松分数的主要危险因素。我们计划研究的假定JPF是脂联素，骨钙素和胰岛素样生长因子-1结合蛋白3（IGF1BP3）。文献中有证据表明，这些假定的JPF与ARD发作的增强和/或延迟有关。 JPF的定义属性是理论上可能是 从外源性来源取代，以重新建立循环中的少年水平，以延迟ARD的发作甚至扭转已建立的ARD。与JPF不同，无法将JPS添加到外源性来源的循环中。但是，通过生活方式和/或药理手段可以实现JP的重大变化。因此，我们将研究这些受保护状态在FLS成年参与者中对ARD发作的少年水平的持久性。 The putative JPS we plan to study include high fat-free mass/ht2 (FFM/ht2), high insulin sensitivity high HDL-cholesterol, and low systolic and/or diastolic blood pressure (SBP/DBP. Should we confirm that some or all of these JPF and JPS are associated with a delayed onset of ARD and/or with an extended life span, our findings may be applied in clinical assessments of individuals JPF和JP的轨迹与预测ARD延迟发作的轨迹不同。 ARD或反向建立的ARD。我们认识到，在采用这种新颖的预防或治疗方法之前，必须清除主要的逻辑和调节障碍。