Exploring Sleep in Neurocognitive Aging and Alzheimer's Research (eSANAR)

探索神经认知衰老和阿尔茨海默病研究中的睡眠 (eSANAR)

• 批准号: 9374776
• 负责人: Alberto Rafael Ramos
• 金额: $ 21.49万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9374776
• 关键词: Address; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; American; Apnea; Blood Vessels; Cardiovascular Diseases; Caribbean region; Central obesity; Circadian Rhythms; Complement; Data; Dementia; Development; Electroencephalogram; Evaluation; Face; Female; Future; Genetic Risk; Habits; High Prevalence; Hispanic Community Health Study/Study of Latinos; Home environment; Hour; Hypoxemia; Injury; Investigation; Knowledge; Language; Latino; Measures; Mediating; Mediation; Memory; Methods; Mexican; Mexican Americans; Neurocognitive; Neurocognitive Deficit; Not Hispanic or Latino; Obesity; Overweight; Participant; Phenotype; Polysomnography; Population; Populations at Risk; Predictive Factor; Predisposition; Prevalence; Public Health; Publishing; Questionnaires; Research; Risk; Risk Factors; Severities; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Fragmentations; Stroke; Testing; Variant; Vascular Diseases; Visit; Woman; Work; actigraphy; base; bench to bedside; cardiovascular disorder risk; cardiovascular risk factor; cerebrovascular; cohort; disorder risk; ethnic minority population; health disparity; interest; middle age; mild cognitive impairment; neurocognitive test; neurovascular; novel; prevent; prospective; sex; symposium; synergism

Project Summary Sleep apnea is a major risk for Alzheimer's disease (AD) and related dementias (ADRD); however, such findings are limited to non-Hispanic whites. There are currently scientific gaps in knowledge about AD risk among Latinos, the largest US ethnic minority. Latinos have a 4-fold increased risk of AD and a 2-fold risk of stroke and cardiovascular diseases, compared to non-Hispanic whites. Of importance, the prevalence of AD and sleep apnea varies across the Latino groups, with higher prevalence among Latinos of Caribbean background. Yet, the current scientific base lacks evidence on the connections and mechanisms between sleep apnea, vascular disease and ADRD, especially among middle-aged and older Latinos. In this study, we efficiently leveraged the baseline and second-wave data of the Hispanic Community Health Study/Study of Latinos (SOL; N=16,415). SOL provides extensive and detailed data on sociocultural, genetic, and cardiovascular risk factors. At baseline, SOL obtained home-sleep test in over 16,000 participants and sleep habits through questionnaires and actigraphy, in a subsample of 2,252 SOL participants. SOL is complemented by the SOL-Investigation of Neurocognitive Aging (SOL-INCA; AG48642) study, which evaluates the prevalence of neurocognitive decline, Mild Cognitive Impairment (MCI) and ADRD among middle-aged and older Latinos of diverse national backgrounds. We hypothesized that sleep apnea, which starts in middle age, disrupts proper neurovascular function and contribute to early neurocognitive decline and MCI/ADRD. We propose to do an exploratory analyses of baseline sleep data and prospective neurocognitive tests, to evaluate 1) the effect of baseline sleep apnea on neurocognitive decline and MCI/ADRD, 2) determine if sleep apnea partly mediates associations between cardiovascular risk factors, neurocognitive decline and MCI/ADRD, and 3) explore actigraphy defined sleep duration and sleep fragmentation as predictors of MCI/ADRD in SOL participants. In synergy with SOL- INCA, our study works within a novel neurovascular developmental approach to understand early neurocognitive decline. We also use culturally sensitive methods among people of diverse Latino backgrounds. This study provides the framework for future SOL studies on sleep and ADRD in Latinos. Evaluating the severity of baseline sleep apnea, levels of hypoxemia, apnea duration, sleep duration and sleep fragmentation, provides an opportunity to refine the sleep phenotypes associated to early neurocognitive decline and MCI/ADRD. This will provide the preliminary data necessary to inform the sleep variables needed for comprehensive sleep assessments with polysomnography and quantitative electroencephalogram. In addition to allowing longitudinal evaluations of sleep and neurocognitive tests to be obtained at SOL visit three.

项目摘要 睡眠呼吸暂停是阿尔茨海默病（AD）和相关痴呆症（ADRD）的主要风险;然而，这些发现 仅限于非西班牙裔白人。目前在拉丁美洲人中对AD风险的认识存在科学差距， 美国最大的少数民族。拉丁美洲人患AD的风险增加4倍，患中风的风险增加2倍， 心血管疾病，与非西班牙裔白人相比。重要的是，AD的患病率和睡眠 呼吸暂停在拉丁美洲群体中各不相同，加勒比背景的拉丁美洲人的患病率较高。然而， 目前的科学基础缺乏睡眠呼吸暂停、血管紧张素转换酶抑制剂和血管紧张素转换酶之间的联系和机制的证据。 疾病和ADRD，特别是在中年和老年人中。在这项研究中，我们有效地利用了 西班牙裔社区健康研究/拉丁裔研究（SOL; N= 16，415）的基线和第二波数据。 SOL提供了关于社会文化、遗传和心血管风险因素的广泛而详细的数据。在基线时， SOL通过问卷调查获得了超过16，000名参与者的家庭睡眠测试和睡眠习惯， 在2,252名SOL参与者的子样本中进行腕动记录。SOL由SOL调查补充， 神经认知老化（SOL-INCA; AG 48642）研究，该研究评估了神经认知衰退的患病率， 不同国籍的中老年拉丁美洲人中的轻度认知障碍（MCI）和ADRD 背景我们假设睡眠呼吸暂停，开始于中年， 功能，并有助于早期神经认知下降和MCI/ADRD。我们建议做一个探索性的 分析基线睡眠数据和前瞻性神经认知测试，以评估1）基线睡眠的影响 呼吸暂停对神经认知功能下降和MCI/ADRD的影响，2）确定睡眠呼吸暂停是否部分介导了 心血管危险因素、神经认知功能下降和MCI/ADRD之间的关系，以及3）探索定义的体动计 睡眠持续时间和睡眠片段作为SOL参与者MCI/ADRD的预测因子。与SOL协同工作- 印加，我们的研究工作在一个新的神经血管发育的方法，以了解早期神经认知 下降我们还在不同拉丁裔背景的人中使用文化敏感的方法。本研究 为未来SOL在拉丁美洲人中的睡眠和ADRD研究提供了框架。评估基线的严重程度 睡眠呼吸暂停、低氧血症水平、呼吸暂停持续时间、睡眠持续时间和睡眠片段，提供了一种 有机会改善与早期神经认知下降和MCI/ADRD相关的睡眠表型。这将 提供必要的初步数据，以告知全面睡眠所需的睡眠变量 多导睡眠图和定量脑电图评估。除了允许纵向 在SOL访视3时获得睡眠和神经认知测试的评价。