Exploring Sleep in Neurocognitive Aging and Alzheimer's Research (eSANAR)

探索神经认知衰老和阿尔茨海默病研究中的睡眠 (eSANAR)

• 批准号: 9374776
• 负责人: Alberto Rafael Ramos
• 金额: $ 21.49万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9374776
• 关键词: Address; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; American; Apnea; Blood Vessels; Cardiovascular Diseases; Caribbean region; Central obesity; Circadian Rhythms; Complement; Data; Dementia; Development; Electroencephalogram; Evaluation; Face; Female; Future; Genetic Risk; Habits; High Prevalence; Hispanic Community Health Study/Study of Latinos; Home environment; Hour; Hypoxemia; Injury; Investigation; Knowledge; Language; Latino; Measures; Mediating; Mediation; Memory; Methods; Mexican; Mexican Americans; Neurocognitive; Neurocognitive Deficit; Not Hispanic or Latino; Obesity; Overweight; Participant; Phenotype; Polysomnography; Population; Populations at Risk; Predictive Factor; Predisposition; Prevalence; Public Health; Publishing; Questionnaires; Research; Risk; Risk Factors; Severities; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Fragmentations; Stroke; Testing; Variant; Vascular Diseases; Visit; Woman; Work; actigraphy; base; bench to bedside; cardiovascular disorder risk; cardiovascular risk factor; cerebrovascular; cohort; disorder risk; ethnic minority population; health disparity; interest; middle age; mild cognitive impairment; neurocognitive test; neurovascular; novel; prevent; prospective; sex; symposium; synergism

Project Summary Sleep apnea is a major risk for Alzheimer's disease (AD) and related dementias (ADRD); however, such findings are limited to non-Hispanic whites. There are currently scientific gaps in knowledge about AD risk among Latinos, the largest US ethnic minority. Latinos have a 4-fold increased risk of AD and a 2-fold risk of stroke and cardiovascular diseases, compared to non-Hispanic whites. Of importance, the prevalence of AD and sleep apnea varies across the Latino groups, with higher prevalence among Latinos of Caribbean background. Yet, the current scientific base lacks evidence on the connections and mechanisms between sleep apnea, vascular disease and ADRD, especially among middle-aged and older Latinos. In this study, we efficiently leveraged the baseline and second-wave data of the Hispanic Community Health Study/Study of Latinos (SOL; N=16,415). SOL provides extensive and detailed data on sociocultural, genetic, and cardiovascular risk factors. At baseline, SOL obtained home-sleep test in over 16,000 participants and sleep habits through questionnaires and actigraphy, in a subsample of 2,252 SOL participants. SOL is complemented by the SOL-Investigation of Neurocognitive Aging (SOL-INCA; AG48642) study, which evaluates the prevalence of neurocognitive decline, Mild Cognitive Impairment (MCI) and ADRD among middle-aged and older Latinos of diverse national backgrounds. We hypothesized that sleep apnea, which starts in middle age, disrupts proper neurovascular function and contribute to early neurocognitive decline and MCI/ADRD. We propose to do an exploratory analyses of baseline sleep data and prospective neurocognitive tests, to evaluate 1) the effect of baseline sleep apnea on neurocognitive decline and MCI/ADRD, 2) determine if sleep apnea partly mediates associations between cardiovascular risk factors, neurocognitive decline and MCI/ADRD, and 3) explore actigraphy defined sleep duration and sleep fragmentation as predictors of MCI/ADRD in SOL participants. In synergy with SOL- INCA, our study works within a novel neurovascular developmental approach to understand early neurocognitive decline. We also use culturally sensitive methods among people of diverse Latino backgrounds. This study provides the framework for future SOL studies on sleep and ADRD in Latinos. Evaluating the severity of baseline sleep apnea, levels of hypoxemia, apnea duration, sleep duration and sleep fragmentation, provides an opportunity to refine the sleep phenotypes associated to early neurocognitive decline and MCI/ADRD. This will provide the preliminary data necessary to inform the sleep variables needed for comprehensive sleep assessments with polysomnography and quantitative electroencephalogram. In addition to allowing longitudinal evaluations of sleep and neurocognitive tests to be obtained at SOL visit three.

项目摘要 睡眠呼吸暂停是阿尔茨海默氏病（AD）和相关痴呆症（ADRD）的主要风险；但是，这样的发现 仅限于非西班牙裔白人。目前，关于拉丁美洲人的AD风险知识的科学差距， 美国最大的少数民族。拉丁美洲人的AD风险增加了4倍，中风风险2倍 与非西班牙裔白人相比，心血管疾病。重要性，广告和睡眠的盛行 呼吸暂停在拉丁裔群体之间各不相同，在加勒比海背景的拉丁美洲人之间的患病率更高。然而， 当前的科学基础缺乏有关睡眠呼吸暂停之间的联系和机制的证据 疾病和ADRD，尤其是在中年和较旧的拉丁裔中。在这项研究中，我们有效利用了 西班牙裔社区健康研究/拉丁裔研究的基线和第二波数据（SOL； n = 16,415）。 SOL提供了有关社会文化，遗传和心血管危险因素的广泛而详细的数据。基线， SOL通过问卷调查获得了超过16,000名参与者和睡眠习惯的家庭睡眠测试 Actraphy，在2,252个SOL参与者的子样本中。 SOL的溶液调查补充了 神经认知衰老（Sol-Inca; AG48642）研究，该研究评估了神经认知下降的流行率， 在多元化国家的中年和较旧的拉丁美洲人中，轻度认知障碍（MCI）和ADRD 背景。我们假设从中年开始的睡眠呼吸暂停会破坏适当的神经血管 功能并有助于早期神经认知下降和MCI/ADRD。我们建议做探索性 基线睡眠数据和前瞻性神经认知测试的分析，以评估1）基线睡眠的影响 神经认知下降和MCI/ADRD的呼吸暂停，2）确定睡眠呼吸暂停是否部分介导关联 在心血管危险因素，神经认知能力下降和MCI/ADRD之间，以及3）探索行为的定义 睡眠持续时间和睡眠碎片作为SOL参与者中MCI/ADRD的预测指标。与溶液协同作用 印加，我们的研究在一种新型的神经血管发育方法中起作用，可以理解早期神经认知 衰退。我们还在不同拉丁裔背景的人中使用对文化敏感的方法。这项研究 为将来关于拉丁美洲人的睡眠和ADRD的SOL研究提供了框架。评估基线的严重程度 睡眠呼吸暂停，低氧血症水平，呼吸暂停持续时间，睡眠时间和睡眠碎片，提供 优化与早期神经认知下降和MCI/ADRD相关的睡眠表型的机会。这会 提供必要的初步数据，以告知全面睡眠所需的睡眠变量 评估多摄影和定量脑电图。除了允许纵向 对SOL访问三次获得的睡眠和神经认知测试的评估。