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Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)

神经认知衰老和阿尔茨海默病研究中的睡眠 (SANAR)

基本信息

批准号：
10156821
负责人：
Alberto Rafael Ramos
金额：
$ 296.06万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-01 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10156821
关键词：
Acculturation Adult Aging Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Ambulatory Blood Pressure Monitoring Ancillary Study Blood Blood Pressure Blood Vessels Cerebrovascular Disorders Cerebrovascular Trauma Clinic Clinical Research Cognition Cognition Disorders Cognitive Data Data Analyses Data Reporting Dementia Diabetes Mellitus Disease Elderly Etiology Exposure to Female Funding Goals Health Health behavior Hispanic Community Health Study/Study of Latinos Hispanics Home Hypertension Impaired cognition Injury Laboratories Latino Link Magnetic Resonance Imaging Measures Mediating Mediation Mental Depression Minority Groups Modeling Modification Neurocognitive Neurocognitive Deficit Not Hispanic or Latino Obesity Obstructive Sleep Apnea Outcome Participant Patient Self-Report Pharmaceutical Preparations Prevention Public Health Publishing Race Research Risk Factors Sampling Site Sleep Sleep Apnea Syndromes Stroke Testing Time Vascular Diseases Visit White Matter Hyperintensity cerebrovascular cognitive function cognitive testing dementia risk design ethnic minority population high risk improved interest middle age mild cognitive impairment modifiable risk mortality novel prevent prospective racial and ethnic vascular risk factor

项目摘要

Latinos have up to a fourfold risk of Alzheimer's disease and related dementias (ADRD) compared to non- Hispanic whites. Further, ADRD onset occurs earlier in Latinos and is often accompanied by vascular risk factors. Consistent with the NIA Alzheimer's prevention Initiative, we will focus on two vascular risk factors never studied in Latino ADRD prevention studies: obstructive sleep apnea (OSA) and non-dipping of blood pressure (NDBP). Over the last decade, OSA has been shown to increase mortality, stroke and vascular disease (e.g. NDBP). OSA is also linked with a 26% increase in cognitive decline or ADRD. However, most studies are limited by the use of self-reported data, measured OSA at a single time point or studied older adults, which do not preclude the possibility of reverse causation. Our published data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL; N≈16,000 at Visit-1), shows that OSA is associated with worse cognitive function, especially in females<55 years. Of interest, OSA had strong associations with prevalent (OR 2.1) and incident hypertension (HR 1.5). In clinical studies, NDBP was more common than clinic hypertension and had stronger associations with stroke and cognition; yet there is no information in the high-risk Latino population. There is an imperative to examine whether OSA in midlife is causal to late life cognitive decline in Latinos, the largest U.S. minority group; findings of important

与非拉丁裔相比，拉丁裔患阿尔茨海默病和相关痴呆(ADRD)的风险高达四倍西班牙裔白人。此外，ADRD发病较早于拉丁裔，且常伴有血管危险因素。与NIA阿尔茨海默氏症预防倡议一致，我们将重点关注两个从未研究过的血管风险因素在拉丁裔ADRD预防研究中：阻塞性睡眠呼吸暂停(OSA)和血压不下降(NDBP)。在过去的十年中，OSA被证明会增加死亡率、中风和血管疾病(例如NDBP)。 OSA还与认知能力下降或ADRD增加26%有关。然而，大多数研究都受到使用自我报告的数据，在单个时间点测量OSA或研究老年人，这不排除反向因果关系的可能性。我们发布的数据来自西班牙裔社区健康研究/ 拉丁裔(HHS/SOL；N≈16,000 at Access-1)表明，阻塞性睡眠呼吸暂停综合征与认知功能较差有关，尤其是55岁的女性。有趣的是，阻塞性睡眠呼吸暂停综合征与流行(OR 2.1)和事件有很强的关联高血压(HR 1.5)。在临床研究中，NDBP比临床高血压更常见，而且有更强的与中风和认知有关；然而，在拉丁裔高危人群中没有相关信息。有一个必须研究中年阻塞性睡眠呼吸暂停是否导致美国最大的拉美裔人晚年认知能力下降。少数群体；重要的发现