Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)

神经认知衰老和阿尔茨海默病研究中的睡眠 (SANAR)

• 批准号: 10156821
• 负责人: Alberto Rafael Ramos
• 金额: $ 296.06万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10156821
• 关键词: Acculturation; Adult; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Ambulatory Blood Pressure Monitoring; Ancillary Study; Blood; Blood Pressure; Blood Vessels; Cerebrovascular Disorders; Cerebrovascular Trauma; Clinic; Clinical Research; Cognition; Cognition Disorders; Cognitive; Data; Data Analyses; Data Reporting; Dementia; Diabetes Mellitus; Disease; Elderly; Etiology; Exposure to; Female; Funding; Goals; Health; Health behavior; Hispanic Community Health Study/Study of Latinos; Hispanics; Home; Hypertension; Impaired cognition; Injury; Laboratories; Latino; Link; Magnetic Resonance Imaging; Measures; Mediating; Mediation; Mental Depression; Minority Groups; Modeling; Modification; Neurocognitive; Neurocognitive Deficit; Not Hispanic or Latino; Obesity; Obstructive Sleep Apnea; Outcome; Participant; Patient Self-Report; Pharmaceutical Preparations; Prevention; Public Health; Publishing; Race; Research; Risk Factors; Sampling; Site; Sleep; Sleep Apnea Syndromes; Stroke; Testing; Time; Vascular Diseases; Visit; White Matter Hyperintensity; cerebrovascular; cognitive function; cognitive testing; dementia risk; design; ethnic minority population; high risk; improved; interest; middle age; mild cognitive impairment; modifiable risk; mortality; novel; prevent; prospective; racial and ethnic; vascular risk factor

Latinos have up to a fourfold risk of Alzheimer's disease and related dementias (ADRD) compared to non- Hispanic whites. Further, ADRD onset occurs earlier in Latinos and is often accompanied by vascular risk factors. Consistent with the NIA Alzheimer's prevention Initiative, we will focus on two vascular risk factors never studied in Latino ADRD prevention studies: obstructive sleep apnea (OSA) and non-dipping of blood pressure (NDBP). Over the last decade, OSA has been shown to increase mortality, stroke and vascular disease (e.g. NDBP). OSA is also linked with a 26% increase in cognitive decline or ADRD. However, most studies are limited by the use of self-reported data, measured OSA at a single time point or studied older adults, which do not preclude the possibility of reverse causation. Our published data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL; N≈16,000 at Visit-1), shows that OSA is associated with worse cognitive function, especially in females<55 years. Of interest, OSA had strong associations with prevalent (OR 2.1) and incident hypertension (HR 1.5). In clinical studies, NDBP was more common than clinic hypertension and had stronger associations with stroke and cognition; yet there is no information in the high-risk Latino population. There is an imperative to examine whether OSA in midlife is causal to late life cognitive decline in Latinos, the largest U.S. minority group; findings of important

与非拉美裔人相比，拉美裔人患阿尔茨海默病和相关痴呆症（ADRD）的风险高达四倍。 西班牙裔白人此外，ADRD在拉丁美洲人中发病较早，通常伴有血管危险因素。 与NIA阿尔茨海默病预防倡议一致，我们将重点关注两个从未研究过的血管风险因素 在拉丁美洲ADRD预防研究中：阻塞性睡眠呼吸暂停（OSA）和血压非下降（NDBP）。 在过去的十年中，OSA已被证明会增加死亡率，中风和血管疾病（例如NDBP）。 OSA还与认知能力下降或ADRD增加26%有关。然而，大多数研究都受到 使用自我报告的数据，在单个时间点测量OSA或研究老年人，这并不排除 反向因果关系的可能性。我们发表的数据来自西班牙裔社区健康研究/研究 拉丁美洲人（HCHS/SOL;访视1时为16，000人），显示OSA与认知功能较差相关， 尤其是55岁以下的女性。值得注意的是，OSA与患病率（OR 2.1）和事件发生率（OR 2.1）有很强的相关性。 高血压（HR 1.5）。在临床研究中，NDBP比临床高血压更常见， 与中风和认知相关;但在高危拉丁裔人群中没有相关信息。有一个 必须检查中年OSA是否是拉丁美洲人晚年认知能力下降的原因，拉丁美洲是美国最大的 少数群体;重要的调查结果