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Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)

神经认知衰老和阿尔茨海默病研究中的睡眠 (SANAR)

基本信息

批准号：
10766955
负责人：
Alberto Rafael Ramos
金额：
$ 16.2万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-01 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10766955
关键词：
Acculturation Adult Aging Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Ambulatory Blood Pressure Monitoring Ancillary Study Blood Blood Pressure Blood Vessels Cerebrovascular Disorders Cerebrovascular Trauma Clinic Clinical Research Cognition Cognition Disorders Cognitive Data Data Analyses Data Reporting Dementia Diabetes Mellitus Disease Disparity Early identification Elderly Ethnic Origin Etiology Exposure to Female Funding Goals Health Health behavior Hispanic Community Health Study/Study of Latinos Home Hypertension Impaired cognition Injury Laboratories Latino Latino Population Link Magnetic Resonance Imaging Measures Mediating Mediation Mental Depression Minority Groups Modeling Modification Neurocognitive Neurocognitive Deficit Not Hispanic or Latino Obesity Obstructive Sleep Apnea Outcome Participant Patient Self-Report Pharmaceutical Preparations Prevention Public Health Publishing Research Risk Factors Sampling Site Sleep Sleep Apnea Syndromes Stroke Testing Time Vascular Diseases Visit White Matter Hyperintensity cerebrovascular cognitive function cognitive testing dementia risk design ethnic minority high risk improvement on sleep interest middle age mild cognitive impairment modifiable risk mortality novel prevent prospective racial population vascular risk factor

项目摘要

Latinos have up to a fourfold risk of Alzheimer's disease and related dementias (ADRD) compared to non- Hispanic whites. Further, ADRD onset occurs earlier in Latinos and is often accompanied by vascular risk factors. Consistent with the NIA Alzheimer's prevention Initiative, we will focus on two vascular risk factors never studied in Latino ADRD prevention studies: obstructive sleep apnea (OSA) and non-dipping of blood pressure (NDBP). Over the last decade, OSA has been shown to increase mortality, stroke and vascular disease (e.g. NDBP). OSA is also linked with a 26% increase in cognitive decline or ADRD. However, most studies are limited by the use of self-reported data, measured OSA at a single time point or studied older adults, which do not preclude the possibility of reverse causation. Our published data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL; N≈16,000 at Visit-1), shows that OSA is associated with worse cognitive function, especially in females<55 years. Of interest, OSA had strong associations with prevalent (OR 2.1) and incident hypertension (HR 1.5). In clinical studies, NDBP was more common than clinic hypertension and had stronger associations with stroke and cognition; yet there is no information in the high-risk Latino population. There is an imperative to examine whether OSA in midlife is causal to late life cognitive decline in Latinos, the largest U.S. minority group; findings of important

拉丁美洲人患阿尔茨海默病和相关痴呆（ADRD）的风险是非拉丁美洲人的四倍