Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)

神经认知衰老和阿尔茨海默病研究中的睡眠 (SANAR)

• 批准号: 10563175
• 负责人: Alberto Rafael Ramos
• 金额: $ 265.06万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10563175
• 关键词: Acculturation; Adult; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Ambulatory Blood Pressure Monitoring; Ancillary Study; Blood; Blood Pressure; Blood Vessels; Cerebrovascular Disorders; Cerebrovascular Trauma; Clinic; Clinical Research; Cognition; Cognition Disorders; Cognitive; Data; Data Analyses; Data Reporting; Dementia; Diabetes Mellitus; Disease; Disparity; Early identification; Elderly; Ethnic Origin; Etiology; Exposure to; Female; Funding; Goals; Health; Health behavior; Hispanic Community Health Study/Study of Latinos; Home; Hypertension; Impaired cognition; Injury; Laboratories; Latino; Latino Population; Link; Magnetic Resonance Imaging; Measures; Mediating; Mediation; Mental Depression; Minority Groups; Modeling; Modification; Neurocognitive; Neurocognitive Deficit; Not Hispanic or Latino; Obesity; Obstructive Sleep Apnea; Outcome; Participant; Patient Self-Report; Pharmaceutical Preparations; Prevention; Public Health; Publishing; Research; Risk Factors; Sampling; Site; Sleep; Sleep Apnea Syndromes; Stroke; Testing; Time; Vascular Diseases; Visit; White Matter Hyperintensity; cerebrovascular; cognitive function; cognitive testing; dementia risk; design; ethnic minority; high risk; improvement on sleep; interest; middle age; mild cognitive impairment; modifiable risk; mortality; novel; prevent; prospective; racial population; vascular risk factor

Latinos have up to a fourfold risk of Alzheimer's disease and related dementias (ADRD) compared to non- Hispanic whites. Further, ADRD onset occurs earlier in Latinos and is often accompanied by vascular risk factors. Consistent with the NIA Alzheimer's prevention Initiative, we will focus on two vascular risk factors never studied in Latino ADRD prevention studies: obstructive sleep apnea (OSA) and non-dipping of blood pressure (NDBP). Over the last decade, OSA has been shown to increase mortality, stroke and vascular disease (e.g. NDBP). OSA is also linked with a 26% increase in cognitive decline or ADRD. However, most studies are limited by the use of self-reported data, measured OSA at a single time point or studied older adults, which do not preclude the possibility of reverse causation. Our published data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL; N≈16,000 at Visit-1), shows that OSA is associated with worse cognitive function, especially in females<55 years. Of interest, OSA had strong associations with prevalent (OR 2.1) and incident hypertension (HR 1.5). In clinical studies, NDBP was more common than clinic hypertension and had stronger associations with stroke and cognition; yet there is no information in the high-risk Latino population. There is an imperative to examine whether OSA in midlife is causal to late life cognitive decline in Latinos, the largest U.S. minority group; findings of important

与非拉丁裔相比，拉丁裔患阿尔茨海默病和相关痴呆症 (ADRD) 的风险高达四倍 西班牙裔白人。此外，拉丁裔 ADRD 发病较早，并且常常伴有血管危险因素。 与 NIA 阿尔茨海默病预防计划一致，我们将重点关注两个从未研究过的血管危险因素 拉丁裔 ADRD 预防研究：阻塞性睡眠呼吸暂停 (OSA) 和血压不下降 (NDBP)。 在过去的十年中，OSA 已被证明会增加死亡率、中风和血管疾​​病（例如 NDBP）。 OSA 还与认知能力下降或 ADRD 增加 26% 有关。然而，大多数研究都受到以下限制： 使用自我报告的数据、在单个时间点测量的 OSA 或研究老年人，这并不排除 反向因果关系的可能性。我们发布的西班牙裔社区健康研究/研究数据 拉丁裔（HCHS/SOL；Visit-1 时 N≈16,000）表明 OSA 与较差的认知功能相关， 尤其是<55岁的女性。有趣的是，OSA 与流行 (OR 2.1) 和事件有很强的关联 高血压（HR 1.5）。临床研究中，NDBP比临床高血压更常见，且具有更强的作用。 与中风和认知的关联；但尚无高危拉丁裔人群的信息。有一个 迫切需要研究中年 OSA 是否会导致美国最大的拉丁裔美国人晚年认知能力下降。 少数群体；重要发现