Sleep in Neurocognitive Aging and Alzheimer’s Research (SANAR)

神经认知衰老和阿尔茨海默病研究中的睡眠 (SANAR)

• 批准号: 10662587
• 负责人: Alberto Rafael Ramos
• 金额: $ 4.05万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662587
• 关键词: Acceleration; Adult; Aging; Alzheimer' s Disease; Ancillary Study; Atrophic; Biological Markers; Blood Pressure; Brain; Brain region; Caring; Cerebral small vessel disease; Chicago; Chronic; Cognition Disorders; Cognitive; Communities; Data; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Elderly; Evaluation; Event; Exposure to; Extracellular Matrix; Hippocampus; Hispanic; Hispanic Community Health Study/Study of Latinos; Hour; Hypoxemia; Hypoxia; Image; Impaired cognition; Injury; Ischemia; K-Series Research Career Programs; Latino; Magnetic Resonance Imaging; Measures; Mediating; Mediator; Medical; Mentors; Metabolic; Modality; Neurocognitive; Neurons; Not Hispanic or Latino; Obstructive Sleep Apnea; Oxygen; Participant; Patient Self-Report; Peripheral; Physicians; Population Database; Predisposition; Protocols documentation; Public Health; Race; Recurrence; Research; Research Infrastructure; Research Training; Risk; Scientist; Severities; Site; Sleep; Sleep Apnea Syndromes; Structure; Testing; Time; United States National Institutes of Health; Visit; Water; White Matter Hyperintensity; blood pressure reduction; career; cerebral hypoperfusion; clinical diagnosis; cognitive change; cognitive function; dementia risk; ethnic diversity; ethnic minority population; gray matter; hypoperfusion; indexing; middle age; novel marker; parent grant; participant enrollment; population based; portability; preservation; prevent; respiratory; socioeconomics; standard of care; tractography; water diffusion; white matter damage

Project Abstract This Diversity Supplement to Sleep in Neurocognitive Aging and Alzheimer's Research (SANAR; R01 AG067568) expands the Parent Grant's examination of how obstructive sleep apnea (OSA) accelerates cognitive decline among US Hispanic/Latino adults, who have > 2-fold risk of dementia and early cognitive decline compared to non-Hispanic Whites. This Supplement examines gray matter (GM) microstructure integrity as an OSA-sleep-related marker of accelerated cognitive decline by testing the hypotheses that (1) OSA is associated with lower GM microstructure integrity, and (2) lower GM microstructure integrity is a marker of accelerated subclinical cognitive decline. This Supplement aims to (1) determine if prior and persistent exposures to (a) OSA and (b) OSA-related hypoxemic burden are associated with lower hippocampal GM microstructure integrity; (2) determine if hippocampal GM microstructure integrity (a) is associated with average 12-year cognitive change among participants with and without OSA, and (b) mediates associations between OSA and 12-year average cognitive change; and (3) determine the independent and interactive association of NDBP and OSA with hippocampal GM microstructure integrity. This Supplement also provides the Diversity Supplement Candidate with mentored research training, structured coursework, and preliminary data vital for an NIH career-development award application, to propel the Diversity Supplement Candidate into a career as an independent physician scientist. This Supplement will utilize the multi-center (Miami, Bronx, Chicago, San Diego), ethnically diverse, community-based Hispanic Community Health Study/Study of Latinos (HCHS/SOL), its ancillary studies (SOL-INCA [R01 AG048642], SOL-INCA-MRI [R01 AG054548]), SOL-INCA2 (R01 AGR56048642), and SANAR (Parent Grant). The Supplement utilizes data from participants enrolled in Miami (n >600), who at baseline were cognitively intact middle-aged and older adults (>/= 45 years) with and without OSA. At Visit 1 (2008- 2011), studies acquired self-reported sleep data, portable sleep apnea studies, and cognitive evaluations. Cognitive evaluations were twice repeated, 7 and 12 years after Visit 1. GM microstructure integirty is quantified as the mean diffusivity of water measured using diffusion tractography imaging (DTI), a modality included in the MRI protocol. MRI was obtained 2016-2022. SANAR enriches this data by obtaining 24-hour ABPM (to measure NDBP) and repeat portable sleep studies 10 years after Visit 1. Analyses will adjust for anthropometric, socioeconomic, racial, and medical confounders.

项目摘要 这种多样性补充睡眠神经认知老化和阿尔茨海默氏症研究（SANAR; R 01 AG 067568）扩展了父母补助金的检查阻塞性睡眠呼吸暂停（OSA）如何加速美国西班牙裔/拉丁美洲成年人的认知下降，与非西班牙裔白人相比，他们患有痴呆症和早期认知下降的风险超过2倍。本增刊通过检验以下假设，将灰质（GM）微结构完整性作为OSA睡眠相关的加速认知衰退标志物进行了研究：（1）OSA与较低的GM微结构完整性相关，（2）较低的GM微结构完整性是加速亚临床认知衰退的标志物。本补充报告旨在（1）确定既往和持续暴露于（a）OSA和（B）OSA相关低氧负荷是否与海马GM微结构完整性降低相关;（2）确定海马GM微结构完整性是否（a）与有和无OSA的参与者的平均12年认知变化相关，以及（B）介导OSA和12年平均认知变化之间的关联;（3）NDBP和OSA与海马GM微结构完整性的独立和交互关系。该补充还为多样性补充候选人提供指导性研究培训，结构化课程和对NIH职业发展奖申请至关重要的初步数据，以推动多样性补充候选人成为独立的医生科学家。本补充资料将使用多中心（迈阿密、布朗克斯、芝加哥、圣地亚哥）、种族多样、基于社区的西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）及其辅助研究（SOL-INCA [R 01 AG 048642]、SOL-INCA-MRI [R 01 AG 054548]）、SOL-INCA 2（R 01 AGR 56048642）和SANAR（父母资助）。该补充利用了在迈阿密登记的参与者（n >600）的数据，这些参与者在基线时是认知功能完整的患有和不患有阻塞性睡眠呼吸暂停综合症的中年和老年人（>/= 45岁）。在访视1（2008- 2011）时，研究获得了自我报告的睡眠数据、便携式睡眠呼吸暂停研究和认知评估。在访视1后7年和12年重复进行两次认知评估。GM微结构完整性被量化为使用扩散纤维束成像（DTI）测量的水的平均扩散率，所述扩散纤维束成像（DTI）是MRI方案中包括的模态。2016-2022年获得MRI。SANAR通过获得24小时ABPM（测量NDBP）并在访视1后10年重复便携式睡眠研究来丰富该数据。分析将调整人体测量、社会经济、种族和医学混杂因素。