Bright and Fast Sensor for Time Resolved X-Ray Diffraction Studies

用于时间分辨 X 射线衍射研究的明亮且快速的传感器

基本信息

  • 批准号:
    7324586
  • 负责人:
  • 金额:
    $ 13.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-08-01 至 2008-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Recent extraordinary developments in synchrotron radiation sources have enabled the growth of powerful research techniques such as time-resolved X-ray diffraction studies for understanding dynamic biological phenomena and recovering phase information in X-ray crystallography. To make the most effective use of these advanced synchrotron sources for important protein studies, however, new, efficient, high- throughput detectors are needed. Such detectors will enhance the quality of the molecular model, which is the end product of the macromolecular crystallography process. Toward achieving this goal, several novel readouts based on new designs of charge-coupled devices have been developed. However, current X-ray-to- light converters that provide low light conversion efficiency, low X-ray absorption, and a tradeoff between spatial resolution and efficiency significantly limit the performance of these powerful devices. To address these issues, we propose to develop a novel semiconductor scintillator that promises to produce as much as a three-fold increase in light yield over the known brightest scintillators, high X-ray absorption due to its high density and high effective atomic number, a fast decay without any afterglow, emission in the wavelength range that is most suitable for CCD-type devices, and orders of magnitude higher radiation resistance than current scintillators. Beyond the excellent scintillation properties of this new and advanced scintillator, it will be fabricated in a microcolumnar form, which will provide very high spatial resolution. When combined with a suitable readout, this scintillator will enable realization of the high speed, large area, high resolution detectors needed for important time-resolved X-ray diffraction and other studies. The goal of the proposed Phase I research is to demonstrate the feasibility of developing the novel scintillator in the described microcolumnar structure using vapor deposition fabrication techniques developed and proven by RMD. After fabrication, the films will be characterized in detail in terms of their morphology, scintillation properties, optical properties and imaging performance at RMD. Films will then be integrated into a specially developed high-speed readout by RMD and evaluated at the BioCAT beam line at the Advanced Photon Source (APS), Argonne National Laboratory, Chicago, IL, to demonstrate their performance superiority compared to current state-of-the-art scintillator screens. During the proposed Phase I/Phase II research, we will undertake efforts to successfully develop and market these screens through our own resources and in collaboration with our commercial partners. Applications of a scintillator with very bright emission, high spatial resolution, high X-ray absorption efficiency, and rapid decay time with no afterglow range widely - from macromolecular crystallography to medical imaging, and from nondestructive testing to polymer research. As such, the commercial potential for this sensor is particularly high. We and our collaborators at the APS believe that due to its extraordinary properties, this scintillator will have widespread use in many important synchrotron-based applications. The proposed research will develop and evaluate a unique scintillator that will provide a factor of three higher light than the brightest commercial scintillators, emission in the red region of the spectrum, high density and high effective atomic number, fast decay time with no afterglow, and orders of magnitude higher radiation resistance compared to the best current scintillators. The availability of such a sensor will enable advancements in the high speed X-ray imaging detector technology needed for many critically important biological studies, such as static and time-resolved scattering from macromolecules. In turn, this will facilitate addressing the important "protein folding problem" and the study of phase transitions in model membrane systems, the understanding of which is vital for many biotechnological applications, such as the design of various drug delivery systems.
描述(由申请人提供):同步辐射源最近的非凡发展使强大的研究技术,如时间分辨X射线衍射研究的增长,用于了解动态生物现象和恢复X射线晶体学中的相位信息。然而,为了最有效地利用这些先进的同步辐射源进行重要的蛋白质研究,需要新的、高效的、高通量的检测器。这种探测器将提高分子模型的质量,这是大分子晶体学过程的最终产品。为了实现这一目标,已经开发了几种基于电荷耦合器件的新设计的新型读出器。然而,提供低光转换效率、低X射线吸收以及空间分辨率与效率之间的折衷的当前X射线到光转换器显著地限制了这些强大装置的性能。为了解决这些问题,我们提出开发一种新型的半导体闪烁体,其有望产生比已知的最亮闪烁体多三倍的光输出增加,由于其高密度和高有效原子序数而产生高X射线吸收,快速衰减而没有任何余辉,在最适合于CCD型器件的波长范围内发射,和比当前的散热器高几个数量级的辐射电阻。除了这种新的先进闪烁体的优异闪烁特性之外,它还将以微柱的形式制造,这将提供非常高的空间分辨率。当与合适的读出相结合时,这种闪烁体将能够实现重要的时间分辨X射线衍射和其他研究所需的高速、大面积、高分辨率探测器。拟议的第一阶段研究的目标是证明使用RMD开发和验证的气相沉积制造技术开发所述微柱结构中的新型闪烁体的可行性。制造后,薄膜将在其形态,闪烁性能,光学性能和成像性能在RMD方面进行详细的表征。然后将胶片集成到RMD专门开发的高速读出器中,并在高级光子源(APS)(阿贡国家实验室,芝加哥,IL)的BioCAT光束线上进行评价,以证明其与当前最先进的闪烁体屏相比的性能优越性。在拟议的第一阶段/第二阶段研究期间,我们将努力通过我们自己的资源并与我们的商业合作伙伴合作,成功开发和销售这些屏幕。闪烁体具有非常明亮的发射,高空间分辨率,高X射线吸收效率和快速衰减时间而没有余辉的应用范围很广-从大分子晶体学到医学成像,从无损检测到聚合物研究。因此,这种传感器的商业潜力特别高。我们和我们在APS的合作者相信,由于其非凡的性能,这种闪烁体将在许多重要的同步加速器应用中得到广泛使用。拟议的研究将开发和评估一种独特的闪烁体,该闪烁体将提供比最亮的商业闪烁体高三倍的光,在光谱的红色区域发射,高密度和高有效原子序数,快速衰减时间,无余辉,以及与最好的电流闪烁体相比更高的辐射抗性。这种传感器的可用性将使高速X射线成像检测器技术的进步,需要许多至关重要的生物学研究,如静态和时间分辨的大分子散射。反过来,这将有助于解决重要的“蛋白质折叠问题”和模型膜系统中的相变研究,理解这一点对于许多生物技术应用至关重要,例如设计各种药物递送系统。

项目成果

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VIVEK V NAGARKAR其他文献

VIVEK V NAGARKAR的其他文献

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{{ truncateString('VIVEK V NAGARKAR', 18)}}的其他基金

Novel High Resolution Scintillator for Imaging Bone Microarchitecture in Flat Panel Cone Beam CT
用于平板锥形束 CT 中骨微结构成像的新型高分辨率闪烁体
  • 批准号:
    9555332
  • 财政年份:
    2018
  • 资助金额:
    $ 13.51万
  • 项目类别:
Dual Mode, Hand-held Intraoperative Imager
双模式手持式术中成像仪
  • 批准号:
    8455692
  • 财政年份:
    2012
  • 资助金额:
    $ 13.51万
  • 项目类别:
Dual Mode, Hand-held Intraoperative Imager
双模式手持式术中成像仪
  • 批准号:
    8551648
  • 财政年份:
    2012
  • 资助金额:
    $ 13.51万
  • 项目类别:
New Design of a Sensor for Ultrahigh Performance SPECT Imaging
用于超高性能 SPECT 成像的传感器的新设计
  • 批准号:
    7800158
  • 财政年份:
    2010
  • 资助金额:
    $ 13.51万
  • 项目类别:
New Design of a Photon Counting Detector for Breast CT
乳腺CT光子计数探测器的新设计
  • 批准号:
    7669824
  • 财政年份:
    2009
  • 资助金额:
    $ 13.51万
  • 项目类别:
Tunable Wavelength, High Efficiency Scintillator for Neutron Crystallography
用于中子晶体学的可调谐波长、高效闪烁体
  • 批准号:
    7746047
  • 财政年份:
    2009
  • 资助金额:
    $ 13.51万
  • 项目类别:
Low Cost High Frame Rate Detector for Macromolecular Diffraction and Scattering
用于大分子衍射和散射的低成本高帧率探测器
  • 批准号:
    7744537
  • 财政年份:
    2009
  • 资助金额:
    $ 13.51万
  • 项目类别:
Reduced Afterglow Scintillator Films for High Speed Medical Imaging
用于高速医学成像的减少余辉闪烁体薄膜
  • 批准号:
    7537767
  • 财政年份:
    2008
  • 资助金额:
    $ 13.51万
  • 项目类别:
Continuous Phoswich Detector for Molecular Imaging
用于分子成像的连续磷光探测器
  • 批准号:
    7537072
  • 财政年份:
    2008
  • 资助金额:
    $ 13.51万
  • 项目类别:
Reduced Afterglow Scintillator Films for High Speed Medical Imaging
用于高速医学成像的减少余辉闪烁体薄膜
  • 批准号:
    7932004
  • 财政年份:
    2008
  • 资助金额:
    $ 13.51万
  • 项目类别:

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