Precision Medicine: Moving Theory into Practice

精准医学：将理论付诸实践

• 批准号: 9752826
• 负责人: DANA P GOLDMAN
• 金额: $ 4.24万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-09 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9752826
• 关键词: Precision; Medicine; Moving; Theory; into

ABSTRACT This research development workshop will provide a collaborative environment for members of the regulatory, economic, payer, clinical, and scientific communities to discuss the utility and limitations of personalized and precision medicine (PPM) and challenges associated with its implementation into health care systems. As an exemplar, we will apply the above perspectives to autoimmune and inflammatory diseases, a rapidly evolving specialty within PPM, in effort to extend PPM beyond oncology and other specialties to which is it commonly applied. The workshop will have the following four aims: 1) We will examine PPM approaches, with an emphasis on those used in autoimmune and inflammatory disease care, from a broad range of perspectives to examine their utility and limitations. The goal will be to determine which approaches—if any—are most likely to fulfill the theoretical promises of PPM when implemented into health care systems. 2) With input from key health care systems stakeholders, we will explore possible considerations and challenges associated with implementing PPM approaches into health care systems. We will then propose an action plan to guide the implementation of the most promising PPM approaches into clinical care. 3) We will develop a research agenda to set priorities for future studies. This agenda will summarize the workshop conclusions and provide a framework for future studies to expand on these findings to better understand the utility and limitations of PPM approaches and accelerate the development and implementation of PPM into standard clinical care. 4) We will develop a Young Investigator Program to motivate a diverse group of students and young investigators to pursue careers in PPM research. Our Program will allow for collaborative networking and exchange of knowledge and ideas among young and established investigators, with the goal of encouraging young investigators to pursue research careers related to PPM, and ultimately submit grant proposal to AHRQ solicitations and contribute to the scientific literature. Overall, this workshop will provide critical new insights and a framework for future research to advance the understanding of PPM and accelerate the development and implementation of PPM into standard clinical care, as well as explore the challenges of implementing PPM approaches into health care systems and strategies for overcoming these challenges.

抽象的 该研究开发研讨会将为监管机构、 经济、付款人、临床和科学界讨论个性化和 精准医学（PPM）及其在医疗保健系统中实施的相关挑战。作为一个 例如，我们将把上述观点应用于自身免疫和炎症疾病，这是一种快速发展的疾病 PPM 内的专业，努力将 PPM 扩展到肿瘤学和其他常见专业之外 应用。研讨会将有以下四个目标： 1）我们将研究 PPM 方法，重点是 对那些用于自身免疫和炎症性疾病护理的药物，从广泛的角度进行检查 它们的效用和局限性。目标是确定哪些方法（如果有的话）最有可能满足 PPM 在医疗保健系统中实施时的理论承诺。 2) 得到关键医疗保健的投入 系统利益相关者，我们将探讨与实施相关的可能的考虑因素和挑战 PPM 进入医疗保健系统。然后我们将提出一个行动计划来指导实施 最有前途的临床护理 PPM 方法。 3）我们将制定一个研究议程来确定优先事项 未来的研究。该议程将总结研讨会的结论并为未来的研究提供框架 扩展这些发现，更好地了解 PPM 方法的实用性和局限性，并加速 将 PPM 开发并实施到标准临床护理中。 4）我们将培养一名青年研究员 该计划旨在激励多元化的学生和年轻研究人员从事 PPM 研究职业。 我们的计划将允许年轻人和年轻人之间建立协作网络并交流知识和想法 建立研究者，目的是鼓励年轻研究者从事相关的研究职业 向 PPM 提交，并最终向 AHRQ 征集提交资助提案并为科学文献做出贡献。 总的来说，本次研讨会将为未来的研究提供重要的新见解和框架，以推进 了解 PPM 并加速将 PPM 开发和实施到标准临床护理中， 以及探讨将 PPM 方法实施到医疗保健系统中的挑战和战略 克服这些挑战。