Translational Neuropsychopharmacology Research of Nicotine Addiction

尼古丁成瘾的转化神经精神药理学研究

基本信息

  • 批准号:
    9753199
  • 负责人:
  • 金额:
    $ 29.28万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-09-15 至 2020-05-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Nicotine addiction is a manifold process that involves dysregulated executive control, reward processing and negative affect. Preclinical models reveal that self-administration of nicotine produces an imbalance in corticostriatal glutamate transmission that mediates cue-induced reinstatement to nicotine seeking. Prior research suggests that N-acetylcysteine (NAC), a modified cysteine chain that regulates glial glutamate and normalizes cocaine-induced synaptic plasticity, may attenuate perceived smoking reward and smoking behavior. Crucially however, our preclinical data suggests NAC may be most effective under conditions of abstinence as a relapse prevention aid. Thus, pairing a smoking cessation medication (Varenicline: VRN) that promotes abstinence, with a relapse prevention aid (NAC), may produce greater cessation outcomes than either treatment alone. The overarching goal of this proposal is to use clinical and preclinical neuroscience to investigate limbic-striatal and corticostriatal circuits involved in nicotine addiction and determine the valueof VRN+NAC for normalizing circuitry function and treating nicotine addiction. Smokers interested in quitting will be randomized to one of four placebo (PBO) controlled conditions to examine the individual and combined effects of VRN and NAC over 4-weeks. Following 1-week of treatment, participants will be contingently reinforced for 3 days of smoking abstinence and undergo an fMRI scan. Participants will be followed over the next 3-weeks of treatment and clinically relevant behaviors will be assessed. Relations between fMRI measures and clinical variable will be explored. In our analog preclinical studies that use the same treatment groups as the clinical studies, we will employ an optogenetic strategy to examine the efficacy of VRN+NAC at inhibiting synaptic plasticity in prelimbic (PL) and basolateral amygdala (BLA) inputs to the nucleus accumbens produced during cue-induced nicotine seeking.


项目成果

期刊论文数量(0)
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Brett Froeliger其他文献

Brett Froeliger的其他文献

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{{ truncateString('Brett Froeliger', 18)}}的其他基金

Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction
尼古丁成瘾中介导食欲调节和吸烟的神经机制
  • 批准号:
    10374104
  • 财政年份:
    2020
  • 资助金额:
    $ 29.28万
  • 项目类别:
Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction
尼古丁成瘾中介导食欲调节和吸烟的神经机制
  • 批准号:
    10596991
  • 财政年份:
    2020
  • 资助金额:
    $ 29.28万
  • 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
  • 批准号:
    10193286
  • 财政年份:
    2020
  • 资助金额:
    $ 29.28万
  • 项目类别:
Examining the effects of Theta Burst Stimulation on corticothalamic mediated inhibitory control and smoking relapse vulnerability
检查 Theta 爆发刺激对皮质丘脑介导的抑制控制和吸烟复吸脆弱性的影响
  • 批准号:
    10245990
  • 财政年份:
    2020
  • 资助金额:
    $ 29.28万
  • 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
  • 批准号:
    9317438
  • 财政年份:
    2015
  • 资助金额:
    $ 29.28万
  • 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
  • 批准号:
    8959706
  • 财政年份:
    2015
  • 资助金额:
    $ 29.28万
  • 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
  • 批准号:
    9534035
  • 财政年份:
    2015
  • 资助金额:
    $ 29.28万
  • 项目类别:
Neuroimaging of Nicotine Dependence, Depression and Emotion Regulation
尼古丁依赖、抑郁和情绪调节的神经影像学
  • 批准号:
    8541802
  • 财政年份:
    2012
  • 资助金额:
    $ 29.28万
  • 项目类别:
Neuroimaging of Nicotine Dependence, Depression and Emotion Regulation
尼古丁依赖、抑郁和情绪调节的神经影像学
  • 批准号:
    9110229
  • 财政年份:
    2012
  • 资助金额:
    $ 29.28万
  • 项目类别:
Neuroimaging of Nicotine Dependence, Depression and Emotion Regulation
尼古丁依赖、抑郁和情绪调节的神经影像学
  • 批准号:
    8895897
  • 财政年份:
    2012
  • 资助金额:
    $ 29.28万
  • 项目类别:

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  • 财政年份:
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    $ 29.28万
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    Clinical Trials and Cohort Studies Grants
High dose acetaminophen with n-acetylcysteine rescue as a novel STAT3 inhibitor with anti-cancer stem cell properties
高剂量对乙酰氨基酚与 n-乙酰半胱氨酸救援作为具有抗癌干细胞特性的新型 STAT3 抑制剂
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使用 N-乙酰半胱氨酸针对自闭症儿童限制性和重复性行为的神经生物学
  • 批准号:
    10221760
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