Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction

尼古丁成瘾中介导食欲调节和吸烟的神经机制

基本信息

  • 批准号:
    10596991
  • 负责人:
  • 金额:
    $ 39.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-08-08 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT Nicotine addiction is a manifold process involving dysregulated brain circuitry subserving reward and motivation (i.e. corticostriatal). Despite extant cross-species models in the literature, there is a gap in the human literature concerning the role of corticostriatal pathways that regulate appetitive processes, whether cognitive training may restructure circuitry function, and whether neuroplasticity in self-regulatory mechanisms alter appetitive behaviors, in particular cigarette smoking. Preliminary data from our laboratory provide initial support for our published model positing that cognitive control training via Mindfulness Oriented Recovery Enhancement (MORE), to enhance valuation of non-drug related reward relative to drug reward may remediate maladaptive appetitive behaviors, craving, and affective deficits by restructuring reward processing. The goal of this proposal is to examine the effects of MORE on corticostriatal mediated regulation of appetitive responding and smoking. Smokers (N=100) will be randomized to 4-weeks of MORE or CBT, undergo fMRI pre/post training, complete a laboratory-based smoking relapse analog task, and be followed for 2-weeks to assess relations between neural function, lab behavior and real-world smoking.
摘要

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Mindful Positive Emotion Regulation as a Treatment for Addiction: From Hedonic Pleasure to Self-Transcendent Meaning.
Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy.
  • DOI:
    10.1016/j.drugalcdep.2022.109361
  • 发表时间:
    2022-04-01
  • 期刊:
  • 影响因子:
    4.2
  • 作者:
    Parisi, Anna;Landicho, Hannah Louise;Hudak, Justin;Leknes, Siri;Froeliger, Brett;Garland, Eric L.
  • 通讯作者:
    Garland, Eric L.
Neurophysiological Deficits During Reappraisal of Negative Emotional Stimuli in Opioid Misuse.
  • DOI:
    10.1016/j.biopsych.2022.01.019
  • 发表时间:
    2022-06-15
  • 期刊:
  • 影响因子:
    10.6
  • 作者:
  • 通讯作者:
Association of Cortico-Striatal Engagement During Cue Reactivity, Reappraisal, and Savoring of Drug and Non-Drug Stimuli With Craving in Heroin Addiction.
  • DOI:
    10.1176/appi.ajp.20220759
  • 发表时间:
    2023-07
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yuefeng Huang;A. Ceceli;G. Kronberg;S. King;P. Malaker;M. Parvaz;N. Alia-Klein;E. Garland;Rita Z. Goldstein
  • 通讯作者:
    Yuefeng Huang;A. Ceceli;G. Kronberg;S. King;P. Malaker;M. Parvaz;N. Alia-Klein;E. Garland;Rita Z. Goldstein
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Brett Froeliger其他文献

Brett Froeliger的其他文献

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{{ truncateString('Brett Froeliger', 18)}}的其他基金

Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction
尼古丁成瘾中介导食欲调节和吸烟的神经机制
  • 批准号:
    10374104
  • 财政年份:
    2020
  • 资助金额:
    $ 39.23万
  • 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
  • 批准号:
    10193286
  • 财政年份:
    2020
  • 资助金额:
    $ 39.23万
  • 项目类别:
Examining the effects of Theta Burst Stimulation on corticothalamic mediated inhibitory control and smoking relapse vulnerability
检查 Theta 爆发刺激对皮质丘脑介导的抑制控制和吸烟复吸脆弱性的影响
  • 批准号:
    10245990
  • 财政年份:
    2020
  • 资助金额:
    $ 39.23万
  • 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
  • 批准号:
    9317438
  • 财政年份:
    2015
  • 资助金额:
    $ 39.23万
  • 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
  • 批准号:
    8959706
  • 财政年份:
    2015
  • 资助金额:
    $ 39.23万
  • 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
  • 批准号:
    9753199
  • 财政年份:
    2015
  • 资助金额:
    $ 39.23万
  • 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
  • 批准号:
    9534035
  • 财政年份:
    2015
  • 资助金额:
    $ 39.23万
  • 项目类别:
Neuroimaging of Nicotine Dependence, Depression and Emotion Regulation
尼古丁依赖、抑郁和情绪调节的神经影像学
  • 批准号:
    9110229
  • 财政年份:
    2012
  • 资助金额:
    $ 39.23万
  • 项目类别:
Neuroimaging of Nicotine Dependence, Depression and Emotion Regulation
尼古丁依赖、抑郁和情绪调节的神经影像学
  • 批准号:
    8541802
  • 财政年份:
    2012
  • 资助金额:
    $ 39.23万
  • 项目类别:
Neuroimaging of Nicotine Dependence, Depression and Emotion Regulation
尼古丁依赖、抑郁和情绪调节的神经影像学
  • 批准号:
    8895897
  • 财政年份:
    2012
  • 资助金额:
    $ 39.23万
  • 项目类别:

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社交媒体上的情感病毒传播:文化和理想情感的作用
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Influence of Physical Activity on Daily Positive Affect & Affective Neural Activity in Preschoolers
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