Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction

摘要 尼古丁成瘾是一个多方面的过程，涉及到大脑回路失调，服从于奖赏和动机。 (即皮质纹状体)。尽管文献中存在跨物种模型，但人类文献中存在一个空白。 关于调节食欲过程的皮质纹状体通路的作用，认知训练是否可以 自我调节机制中的神经可塑性是否会改变食欲 行为，特别是吸烟。我们实验室的初步数据为我们的 已发表的模型认为，认知控制训练通过正念导向的恢复增强 (更多)，提高非毒品相关奖励相对于毒品奖励的估值可能会补救适应不良 通过重组奖赏加工的食欲行为、渴求和情感缺陷。这项提案的目标是 是为了研究More对皮质纹状体调节食欲反应和吸烟的影响。 吸烟者(N=100)将随机接受为期4周的MORE或CBT，接受功能磁共振前/后训练，完成 以实验室为基础的吸烟复发模拟任务，并追踪2周以评估神经之间的关系 功能、实验室行为和现实世界中的吸烟。

ABSTRACT Nicotine addiction is a manifold process involving dysregulated brain circuitry subserving reward and motivation (i.e. corticostriatal). Despite extant cross-species models in the literature, there is a gap in the human literature concerning the role of corticostriatal pathways that regulate appetitive processes, whether cognitive training may restructure circuitry function, and whether neuroplasticity in self-regulatory mechanisms alter appetitive behaviors, in particular cigarette smoking. Preliminary data from our laboratory provide initial support for our published model positing that cognitive control training via Mindfulness Oriented Recovery Enhancement (MORE), to enhance valuation of non-drug related reward relative to drug reward may remediate maladaptive appetitive behaviors, craving, and affective deficits by restructuring reward processing. The goal of this proposal is to examine the effects of MORE on corticostriatal mediated regulation of appetitive responding and smoking. Smokers (N=100) will be randomized to 4-weeks of MORE or CBT, undergo fMRI pre/post training, complete a laboratory-based smoking relapse analog task, and be followed for 2-weeks to assess relations between neural function, lab behavior and real-world smoking.