Examining the effects of Theta Burst Stimulation on corticothalamic mediated inhibitory control and smoking relapse vulnerability

摘要 烟草使用障碍（TUD）与其他药物滥用一样，与前额叶介导的抑制性功能缺陷有关。 控制（IC）-停止pre-potent行为反应的能力。我们最近报道的研究结果表明，IC 右侧额下回与丘脑之间的任务功能连接 （皮质丘脑回路）介导成功抑制和吸烟复发/复吸之间的关联 在实验室和戒烟研究中的脆弱性。我们实验室的初步数据显示， 使用间歇性θ脉冲串刺激（iTBS）-诱导长时程增强和增强 加强网络活动，以r.IFG显着提高抑制控制任务的性能， 个人TUD本提案的目的是研究TBS效应的机制基础 对皮质丘脑介导的抑制控制和吸烟的影响，并评估是否调节皮质丘脑 tbFC转化为改善的抑制控制和减少TUD个体中的吸烟失效/复发。

ABSTRACT Tobacco use disorder (TUD), like other drugs of abuse, is associated with deficits in prefrontal mediated inhibitory control (IC)—the ability to stop pre-potent behavioral responding. We recently reported findings showing that IC task-based functional connectivity (tbFC) between the right inferior frontal gyrus (r.IFG) and thalamus (corticothalamic circuit) mediated the association between successful inhibition and smoking lapse / relapse vulnerability in the laboratory and in a smoking cessation study. Preliminary data from our laboratory shows that using intermittent theta burst stimulation (iTBS)—which induces long-term potentiation and putatively strengthens network activity—to the r.IFG significantly improves inhibitory control task performance among individuals with TUD. The goal of this proposal is to examine the mechanistic underpinnings of the effects of TBS on corticothalamic mediated inhibitory control and smoking and evaluate whether modulating corticothalamic tbFC translates to improved inhibitory control and reducing smoking lapse/relapse among individuals with TUD.