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Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction

尼古丁成瘾中介导食欲调节和吸烟的神经机制

基本信息

批准号：
10374104
负责人：
Brett Froeliger
金额：
$ 44.14万
依托单位：
UNIVERSITY OF MISSOURI-COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-08 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10374104
关键词：
Adult Affect Affective Amygdaloid structure Animal Model Appetite Regulation Appetitive Behavior Attenuated Back Basic Science Behavior Behavior Therapy Behavioral Mechanisms Brain Brain Diseases Centers for Disease Control and Prevention (U.S.)Cessation of life Chronic Cigarette Clinical Clinical Research Clinical Trials Cognitive Therapy Control Groups Controlled Study Cues Data Desire for food Drug usage Emotional Event Exhibits Exposure to FDA approved Functional Magnetic Resonance Imaging Functional disorder Goals Human Individual Insula of Reil Knowledge Laboratories Lateral Literature Medial Mediating Mediation Mindfulness Training Mission Modeling Motivation National Institute of Drug Abuse Neuronal Plasticity Neurophysiology - biologic function Neurosciences Neurosciences Research Nicotine Dependence Opioid Outcome Pathway interactions Patient Self-Report Pharmaceutical Preparations Pharmacotherapy Pilot Projects Pre-Clinical Model Prefrontal Cortex Process Publishing Randomized Randomized Clinical Trials Recovery Relapse Research Rest Rewards Role Severities Signal Transduction Smoke Smoker Smoking Smoking Behavior Substance Use Disorder Task Performances Testing Thalamic structure Time TimeLine Tobacco Use Disorder Tobacco use Training Translations Ventral Striatum Work analog base behavior change blood oxygenation level dependent response brain circuitry cigarette smoking cognitive control cognitive reappraisal cognitive training craving cue reactivity design drug reward emotion regulation experimental study follow-up human model improved mindfulness mindfulness intervention multidisciplinary neurobiological mechanism neuromechanism neuroregulation non-drug opioid misuse positive emotional state premature primary outcome reinforcer relating to nervous system response reward processing smoking abstinence smoking cessation smoking relapse social substance use treatment

项目摘要

ABSTRACT Nicotine addiction is a manifold process involving dysregulated brain circuitry subserving reward and motivation (i.e. corticostriatal). Despite extant cross-species models in the literature, there is a gap in the human literature concerning the role of corticostriatal pathways that regulate appetitive processes, whether cognitive training may restructure circuitry function, and whether neuroplasticity in self-regulatory mechanisms alter appetitive behaviors, in particular cigarette smoking. Preliminary data from our laboratory provide initial support for our published model positing that cognitive control training via Mindfulness Oriented Recovery Enhancement (MORE), to enhance valuation of non-drug related reward relative to drug reward may remediate maladaptive appetitive behaviors, craving, and affective deficits by restructuring reward processing. The goal of this proposal is to examine the effects of MORE on corticostriatal mediated regulation of appetitive responding and smoking. Smokers (N=100) will be randomized to 4-weeks of MORE or CBT, undergo fMRI pre/post training, complete a laboratory-based smoking relapse analog task, and be followed for 2-weeks to assess relations between neural function, lab behavior and real-world smoking.

摘要尼古丁成瘾是一个多方面的过程，涉及大脑回路失调，从而促进奖励和动机 (i.e.皮质纹状体的）。尽管文献中存在跨物种模型，但在人类文献中存在空白关于调节食欲过程的皮质纹状体通路的作用，认知训练是否可以重组电路功能，以及自我调节机制中的神经可塑性是否会改变食欲行为，特别是吸烟。我们实验室的初步数据为我们的研究提供了初步支持。发表的模型认为，通过正念导向恢复增强的认知控制训练（更多），相对于药物奖励，提高非药物相关奖励的价值可能会纠正适应不良食欲行为，渴望，和情感缺陷的重组奖励处理。这项提案的目的是研究MORE对皮质纹状体介导的食欲反应和吸烟调节的影响。吸烟者（N=100）将被随机分配至4周的MORE或CBT组，接受训练前/后的fMRI检查，完成一项基于实验室的吸烟复吸模拟任务，并随访2周以评估神经元之间的关系功能、实验室行为和现实世界的吸烟。