Translational Neuropsychopharmacology Research of Nicotine Addiction

尼古丁成瘾的转化神经精神药理学研究

• 批准号: 10193286
• 负责人: Brett Froeliger
• 金额: $ 15.5万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-16 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10193286
• 关键词: Translational; Neuropsychopharmacology; Research; Nicotine; Addiction

Nicotine addiction is a manifold process that involves dysregulated executive control, reward processing and negative affect. Preclinical models reveal that self-administration of nicotine produces an imbalance in corticostriatal glutamate transmission that mediates cue-induced reinstatement to nicotine seeking. Prior research suggests that N- acetylcysteine (NAC), a modified cysteine chain that regulates glial glutamate and normalizes cocaine-induced synaptic plasticity, may attenuate perceived smoking reward and smoking behavior. Crucially however, our preclinical data suggests NAC may be most effective under conditions of abstinence as a relapse prevention aid. Thus, pairing a smoking cessation medication (Varenicline: VRN) that promotes abstinence, with a relapse prevention aid (NAC), may produce greater cessation outcomes than either treatment alone. The overarching goal of this proposal is to use clinical and preclinical neuroscience to investigate limbic-striatal and corticostriatal circuits involved in nicotine addiction and determine the value of VRN+NAC for normalizing circuitry function and treating nicotine addiction. Smokers interested in quitting will be randomized to one of four placebo (PBO) controlled conditions to examine the individual and combined effects of VRN and NAC over 4-weeks. Following 1-week of treatment, participants will be contingently reinforced for 3 days of smoking abstinence and undergo an fMRI scan. Participants will be followed over the next 3-weeks of treatment and clinically relevant behaviors will be assessed. Relations between fMRI measures and clinical variable will be explored. In our analog preclinical studies that use the same treatment groups as the clinical studies, we will employ an optogenetic strategy to examine the efficacy of VRN+NAC at inhibiting synaptic plasticity in prelimbic (PL) and basolateral amygdala (BLA) inputs to the nucleus accumbens produced during cue-induced nicotine seeking.

尼古丁成瘾是一个复杂的过程，包括失调的执行控制，奖励处理和

项目成果

Mindfulness, Acceptance and Defusion Strategies in Smokers: a Systematic Review of Laboratory Studies.

吸烟者的正念、接受和解离策略：实验室研究的系统回顾。

• DOI: 10.1007/s12671-017-0767-1
• 发表时间: 2018
• 期刊: Mindfulness
• 影响因子: 3.6
• 作者: Serfaty,Shirley;Gale,Grace;Beadman,Matthew;Froeliger,Brett;Kamboj,SunjeevK
• 通讯作者: Kamboj,SunjeevK

Smokers' Neurological Responses to Novel and Repeated Health Warning Labels (HWLs) From Cigarette Packages.

• DOI: 10.3389/fpsyt.2018.00319
• 发表时间: 2018
• 期刊: Frontiers in psychiatry
• 影响因子: 4.7
• 作者: Fridriksson JF;Rorden C;Newman-Norlund RD;Froeliger B;Thrasher JF
• 通讯作者: Thrasher JF