Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
基本信息
- 批准号:10193286
- 负责人:
- 金额:$ 15.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-16 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Nicotine addiction is a manifold process that involves dysregulated executive control, reward processing and
negative affect. Preclinical models reveal that self-administration of nicotine produces an imbalance in corticostriatal
glutamate transmission that mediates cue-induced reinstatement to nicotine seeking. Prior research suggests that N-
acetylcysteine (NAC), a modified cysteine chain that regulates glial glutamate and normalizes cocaine-induced synaptic
plasticity, may attenuate perceived smoking reward and smoking behavior. Crucially however, our preclinical data
suggests NAC may be most effective under conditions of abstinence as a relapse prevention aid. Thus, pairing a
smoking cessation medication (Varenicline: VRN) that promotes abstinence, with a relapse prevention aid (NAC),
may produce greater cessation outcomes than either treatment alone. The overarching goal of this proposal is to use
clinical and preclinical neuroscience to investigate limbic-striatal and corticostriatal circuits involved in nicotine
addiction and determine the value of VRN+NAC for normalizing circuitry function and treating nicotine
addiction. Smokers interested in quitting will be randomized to one of four placebo (PBO) controlled conditions to
examine the individual and combined effects of VRN and NAC over 4-weeks. Following 1-week of treatment,
participants will be contingently reinforced for 3 days of smoking abstinence and undergo an fMRI scan.
Participants will be followed over the next 3-weeks of treatment and clinically relevant behaviors will be assessed.
Relations between fMRI measures and clinical variable will be explored. In our analog preclinical studies that use the
same treatment groups as the clinical studies, we will employ an optogenetic strategy to examine the efficacy of
VRN+NAC at inhibiting synaptic plasticity in prelimbic (PL) and basolateral amygdala (BLA) inputs to the
nucleus accumbens produced during cue-induced nicotine seeking.
尼古丁成瘾是一个复杂的过程,包括失调的执行控制,奖励处理和
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Mindfulness, Acceptance and Defusion Strategies in Smokers: a Systematic Review of Laboratory Studies.
吸烟者的正念、接受和解离策略:实验室研究的系统回顾。
- DOI:10.1007/s12671-017-0767-1
- 发表时间:2018
- 期刊:
- 影响因子:3.6
- 作者:Serfaty,Shirley;Gale,Grace;Beadman,Matthew;Froeliger,Brett;Kamboj,SunjeevK
- 通讯作者:Kamboj,SunjeevK
Smokers' Neurological Responses to Novel and Repeated Health Warning Labels (HWLs) From Cigarette Packages.
- DOI:10.3389/fpsyt.2018.00319
- 发表时间:2018
- 期刊:
- 影响因子:4.7
- 作者:Fridriksson JF;Rorden C;Newman-Norlund RD;Froeliger B;Thrasher JF
- 通讯作者:Thrasher JF
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Brett Froeliger其他文献
Brett Froeliger的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Brett Froeliger', 18)}}的其他基金
Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction
尼古丁成瘾中介导食欲调节和吸烟的神经机制
- 批准号:
10374104 - 财政年份:2020
- 资助金额:
$ 15.5万 - 项目类别:
Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction
尼古丁成瘾中介导食欲调节和吸烟的神经机制
- 批准号:
10596991 - 财政年份:2020
- 资助金额:
$ 15.5万 - 项目类别:
Examining the effects of Theta Burst Stimulation on corticothalamic mediated inhibitory control and smoking relapse vulnerability
检查 Theta 爆发刺激对皮质丘脑介导的抑制控制和吸烟复吸脆弱性的影响
- 批准号:
10245990 - 财政年份:2020
- 资助金额:
$ 15.5万 - 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
- 批准号:
9317438 - 财政年份:2015
- 资助金额:
$ 15.5万 - 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
- 批准号:
8959706 - 财政年份:2015
- 资助金额:
$ 15.5万 - 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
- 批准号:
9753199 - 财政年份:2015
- 资助金额:
$ 15.5万 - 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
- 批准号:
9534035 - 财政年份:2015
- 资助金额:
$ 15.5万 - 项目类别:
Neuroimaging of Nicotine Dependence, Depression and Emotion Regulation
尼古丁依赖、抑郁和情绪调节的神经影像学
- 批准号:
8541802 - 财政年份:2012
- 资助金额:
$ 15.5万 - 项目类别:
Neuroimaging of Nicotine Dependence, Depression and Emotion Regulation
尼古丁依赖、抑郁和情绪调节的神经影像学
- 批准号:
9110229 - 财政年份:2012
- 资助金额:
$ 15.5万 - 项目类别:
Neuroimaging of Nicotine Dependence, Depression and Emotion Regulation
尼古丁依赖、抑郁和情绪调节的神经影像学
- 批准号:
8895897 - 财政年份:2012
- 资助金额:
$ 15.5万 - 项目类别:
相似海外基金
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
- 批准号:
9317438 - 财政年份:2015
- 资助金额:
$ 15.5万 - 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
- 批准号:
8959706 - 财政年份:2015
- 资助金额:
$ 15.5万 - 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
- 批准号:
9753199 - 财政年份:2015
- 资助金额:
$ 15.5万 - 项目类别:
Translational Neuropsychopharmacology Research of Nicotine Addiction
尼古丁成瘾的转化神经精神药理学研究
- 批准号:
9534035 - 财政年份:2015
- 资助金额:
$ 15.5万 - 项目类别:
NEUROPSYCHOPHARMACOLOGY TRAINING FOR DRUG ABUSE RESEARCH
药物滥用研究的神经心理药理学培训
- 批准号:
2013076 - 财政年份:1991
- 资助金额:
$ 15.5万 - 项目类别:
NEUROPSYCHOPHARMACOLOGY TRAINING FOR DRUG ABUSE RESEARCH
药物滥用研究的神经心理药理学培训
- 批准号:
6378519 - 财政年份:1991
- 资助金额:
$ 15.5万 - 项目类别:
Neuropsychopharmacology training for drug abuse research
药物滥用研究的神经精神药理学培训
- 批准号:
6453881 - 财政年份:1991
- 资助金额:
$ 15.5万 - 项目类别:
Neuropsychopharmacology Training for Drug Abuse Research
药物滥用研究的神经精神药理学培训
- 批准号:
7888128 - 财政年份:1991
- 资助金额:
$ 15.5万 - 项目类别:
Neuropsychopharmacology training for drug abuse research
药物滥用研究的神经精神药理学培训
- 批准号:
7122914 - 财政年份:1991
- 资助金额:
$ 15.5万 - 项目类别:
Neuropsychopharmacology Training for Drug Abuse Research
药物滥用研究的神经精神药理学培训
- 批准号:
7669299 - 财政年份:1991
- 资助金额:
$ 15.5万 - 项目类别: