Sleep in children with fetal alcohol spectrum disorders

患有胎儿酒精谱系障碍的儿童的睡眠

• 批准号: 9752126
• 负责人: JENNIFER D THOMAS
• 金额: $ 24.45万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9752126
• 关键词: Aggressive behavior; Alcohols; Anxiety; Area; Arousal; Attention; Attention deficit hyperactivity disorder; Behavior; Behavioral; Blood specimen; Brain; Cardiovascular Diseases; Caregivers; Characteristics; Child; Child Behavior; Child Behavior Checklist; Childhood; Circadian Rhythms; Cognition; Cognitive; Data; Data Reporting; Development; Effectiveness of Interventions; Emotional; Emotions; Equipment and supply inventories; Executive Dysfunction; Exhibits; Family; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal alcohol effects; Foundations; Functional disorder; Future; Gene Expression; Genes; Hyperactive behavior; Individual; Intervention; Learning; Literature; Measures; Mediating; Melatonin; Memory; Mental Depression; Messenger RNA; Moods; Neurodevelopmental Disability; Obesity; Outcome; Parasomnias; Parents; Pattern; Periodicity; Population; Prefrontal Cortex; Prevalence; Problem behavior; Proxy; Public Health; Quality of life; Questionnaires; Reporting; Research; Resistance; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Fragmentations; Sleep disturbances; Stress; System; Time; United States National Institutes of Health; actigraphy; aged; circadian; cognitive function; cost; design; developmental disease; diaries; differential expression; executive function; improved; inattention; language processing; neurobehavioral; pre-clinical; preclinical study; processing speed; sleep behavior; sleep quality; wearable technology

ABSTRACT Caregivers of children with fetal alcohol spectrum disorders (FASD) often report that their child has problems with sleep. However, despite decades of research on the consequences of prenatal alcohol exposure, sleep behaviors are grossly understudied, even though sleep disturbances may mediate or exacerbate some of the cognitive and emotional effects of prenatal alcohol exposure and could serve as a potential target for intervention. In fact, sleep difficulties are related to neurobehavioral deficits in typically developing populations and may have more robust effects on neurobehavioral functioning among individuals with developmental disorders. We hypothesize that children with FASD will demonstrate greater sleep disturbance compared to controls. We also predict that sleep disturbance will be related to increased emotional reactivity, hyperactivity, aggression, and depression, and greater deficits in executive functioning, memory, and attention. Moreover, preclinical studies indicate that prenatal alcohol exposure can disrupt the clock genes that control circadian rhythmicity at a cellular level. Thus, we hypothesize that clock genes will be expressed differently in children with prenatal alcohol exposure. First, this proposal will examine sleep in children with FASD with both wearable technology and subjective measures. Secondly, the relationship between sleep quality and neurobehavioral outcome will be examined. Finally, as an exploratory aim, we will determine if children with FASD exhibit differential expression of clock genes. These data will allow us to better understand the effects of prenatal alcohol exposure on sleep and lay the foundation for developing targeted interventions that may not only improve sleep, but also have the potential for enhancing functioning in other cognitive and emotional domains as well.

摘要 胎儿酒精谱系障碍（FASD）儿童的照顾者经常报告他们的孩子有问题 睡眠。然而，尽管对产前酒精暴露的后果进行了数十年的研究， 尽管睡眠障碍可能会介导或加剧某些行为， 产前酒精暴露的认知和情绪影响，并可能作为一个潜在的目标， 干预事实上，睡眠困难与典型发育人群的神经行为缺陷有关 并且可能对发育不良的个体的神经行为功能产生更强有力的影响 紊乱我们假设，FASD儿童将表现出更大的睡眠障碍相比， 对照我们还预测，睡眠障碍将与情绪反应性增加、多动、 攻击性，抑郁症，以及执行功能，记忆力和注意力的更大缺陷。此外，委员会认为， 临床前研究表明，产前酒精暴露会破坏控制昼夜节律的生物钟基因， 细胞水平的节律性。因此，我们假设时钟基因在儿童中的表达会有所不同 产前酒精暴露首先，该提案将检查患有FASD的儿童的睡眠， 技术和主观措施。第二，睡眠质量与神经行为的关系 将审查结果。最后，作为一个探索性的目标，我们将确定FASD儿童是否表现出 时钟基因的差异表达。这些数据将使我们更好地了解产前检查的影响 酒精暴露对睡眠的影响，并为制定有针对性的干预措施奠定基础， 改善睡眠，但也有可能增强其他认知和情感领域的功能 也