FASEB SRC on Protein Kinases and Protein Phosphorylation

FASEB SRC 关于蛋白激酶和蛋白磷酸化

基本信息

  • 批准号:
    9754337
  • 负责人:
  • 金额:
    $ 0.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-07-03 至 2020-06-30
  • 项目状态:
    已结题

项目摘要

Program Director/Principal Investigator : Zhang, Jin Protein phosphorylation is vitally important in the molecular communications that control cellular state and activity. It is a dynamic process mediated by kinases and phosphatases that are precisely regulated in normal cells, and deregulated in many human diseases, including diabetes, inflammatory disease and cancer. The study of the protein phosphorylation machinery and its function in signaling systems is a robustly active area of research that has driven methodological and conceptual advances and is increasingly contributing to the development of therapeutic options. Protein kinases are frequently deregulated in cancer, and they have been the focus of intense recent interest by the pharmaceutical industry. Indeed, most new cancer drugs approved by the FDA in the last several years target kinases, and there are hundreds of new kinase inhibitors under development. This strong clinical connection provides an exciting link with translational science. In this application, we request funds to support attendance of trainees, junior faculty and traditionally underrepresented groups at the 2019 FASEB Summer Research conference on Protein Kinases and Protein Phosphorylation. This biennial conference started in 1983, and is an important interdisciplinary gathering that brings together scientists with diverse expertise to advance understanding of the biochemical mechanisms and fundamental principles of phosphorylation events – a focus that distinguishes this meeting from others that deal with signaling networks and systems approaches. This FASEB meeting has been, and continues to be, a primary venue for the announcement of breakthroughs in the field, and has a long-standing goal to enhance, and disseminate, knowledge that will lead to improved therapies to target aberrant kinase activity, and protein phosphorylation, in human disease. The 2019 FASEB Science Research Conference on Protein Kinases and Protein Phosphorylation aims to highlight recent, cutting-edge findings in the field of protein phosphorylation, to bring together structural biology, biochemistry, systems biology, chemical biology, protein engineering, and medicine. This will promote cross-fertilization among these normally separate disciplines to stimulate new lines of research, as well as to enhance communication, collaboration, career advancement for the diverse scientists in the field. The ultimate goal is to advance the field to obtain better understandings of the molecular mechanisms that regulate important biological processes and facilitate the identification of critical targets for the diagnosis, prevention, treatment, and cure of human diseases. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page
项目主任/首席研究员:张晋

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jin Zhang其他文献

Jin Zhang的其他文献

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{{ truncateString('Jin Zhang', 18)}}的其他基金

Integrating multi-omics, imaging, and longitudinal data to predict radiation response in cervical cancer
整合多组学、成像和纵向数据来预测宫颈癌的放射反应
  • 批准号:
    10734702
  • 财政年份:
    2023
  • 资助金额:
    $ 0.4万
  • 项目类别:
HPV genomic structure in cervical cancer radiation response and recurrence detection
HPV基因组结构在宫颈癌放射反应和复发检测中的作用
  • 批准号:
    10634999
  • 财政年份:
    2023
  • 资助金额:
    $ 0.4万
  • 项目类别:
Deep learning in cervical cancer radiogenomics
宫颈癌放射基因组学中的深度学习
  • 批准号:
    10643978
  • 财政年份:
    2022
  • 资助金额:
    $ 0.4万
  • 项目类别:
Deep learning in cervical cancer radiogenomics
宫颈癌放射基因组学中的深度学习
  • 批准号:
    10424854
  • 财政年份:
    2022
  • 资助金额:
    $ 0.4万
  • 项目类别:
HPV alternative splicing in cervical cancer radiation response
HPV选择性剪接在宫颈癌放射反应中的作用
  • 批准号:
    10308435
  • 财政年份:
    2020
  • 资助金额:
    $ 0.4万
  • 项目类别:
HPV alternative splicing in cervical cancer radiation response
HPV选择性剪接在宫颈癌放射反应中的作用
  • 批准号:
    9891761
  • 财政年份:
    2020
  • 资助金额:
    $ 0.4万
  • 项目类别:
HPV alternative splicing in cervical cancer radiation response
HPV选择性剪接在宫颈癌放射反应中的作用
  • 批准号:
    10523104
  • 财政年份:
    2020
  • 资助金额:
    $ 0.4万
  • 项目类别:
Live-cell Activity Architecture in Cancer
癌症中的活细胞活性结构
  • 批准号:
    10673027
  • 财政年份:
    2015
  • 资助金额:
    $ 0.4万
  • 项目类别:
Live-cell Activity Architecture in Cancer
癌症中的活细胞活性结构
  • 批准号:
    9319218
  • 财政年份:
    2015
  • 资助金额:
    $ 0.4万
  • 项目类别:
Signal Transduction by PI3K/Akt/mTOR Pathway
通过 PI3K/Akt/mTOR 途径进行信号转导
  • 批准号:
    9108384
  • 财政年份:
    2015
  • 资助金额:
    $ 0.4万
  • 项目类别:

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