FASEB SRC on Protein Kinases and Protein Phosphorylation

项目主任/首席调查员：张进 蛋白质磷酸化在分子通信中至关重要，分子通信控制细胞状态和 活动。这是一个由正常人群中精确调控的激酶和磷酸酶介导的动态过程。 在许多人类疾病中，包括糖尿病、炎症性疾病和癌症，都是去调节的。这个 蛋白质磷酸化机制及其在信号系统中作用的研究是一个非常活跃的领域 推动了方法学和概念进步的研究，并越来越多地为 治疗方案的发展。蛋白激酶在癌症中经常被解除调控，它们一直是 这是制药业最近强烈兴趣的焦点。事实上，大多数抗癌新药都已获批 在过去的几年里被FDA以激酶为靶标，目前已有数百种新的激酶抑制剂在 发展。这种强大的临床联系提供了与翻译科学的令人兴奋的联系。 在这项申请中，我们申请资金以支持学员、初级教员和传统的 在2019年FASEB关于蛋白激酶和蛋白质的夏季研究会议上代表不足的群体 磷酸化。这一两年一度的会议始于1983年，是一次重要的跨学科会议， 将具有不同专业知识的科学家聚集在一起，以促进对生化机制和 磷酸化事件的基本原则-这次会议有别于其他会议的一个焦点 处理信令网络和系统方法。这次FASEB会议一直是，并将继续是 宣布该领域突破的主要地点，并有一个长期的目标要增强， 并传播知识，这些知识将导致针对异常激酶活性和蛋白质的改进治疗 磷酸化，在人类疾病中。2019年FASE B蛋白激酶和蛋白质组科学研究会议 蛋白质磷酸化旨在突出蛋白质磷酸化领域的最新前沿发现，以 将结构生物学、生物化学、系统生物学、化学生物学、蛋白质工程和 医药。这将促进这些通常独立的学科之间的交叉受精，以刺激新的系列 以及加强不同科学家的交流、合作和职业发展 在战场上。最终目标是推进这一领域，以获得对分子的更好理解 调节重要生物过程并促进确定关键目标的机制 人类疾病的诊断、预防、治疗和治疗。 OMB编号0925-0001/0002(01/18修订版批准至2020年3月31日)页面续格式页面

Program Director/Principal Investigator : Zhang, Jin Protein phosphorylation is vitally important in the molecular communications that control cellular state and activity. It is a dynamic process mediated by kinases and phosphatases that are precisely regulated in normal cells, and deregulated in many human diseases, including diabetes, inflammatory disease and cancer. The study of the protein phosphorylation machinery and its function in signaling systems is a robustly active area of research that has driven methodological and conceptual advances and is increasingly contributing to the development of therapeutic options. Protein kinases are frequently deregulated in cancer, and they have been the focus of intense recent interest by the pharmaceutical industry. Indeed, most new cancer drugs approved by the FDA in the last several years target kinases, and there are hundreds of new kinase inhibitors under development. This strong clinical connection provides an exciting link with translational science. In this application, we request funds to support attendance of trainees, junior faculty and traditionally underrepresented groups at the 2019 FASEB Summer Research conference on Protein Kinases and Protein Phosphorylation. This biennial conference started in 1983, and is an important interdisciplinary gathering that brings together scientists with diverse expertise to advance understanding of the biochemical mechanisms and fundamental principles of phosphorylation events – a focus that distinguishes this meeting from others that deal with signaling networks and systems approaches. This FASEB meeting has been, and continues to be, a primary venue for the announcement of breakthroughs in the field, and has a long-standing goal to enhance, and disseminate, knowledge that will lead to improved therapies to target aberrant kinase activity, and protein phosphorylation, in human disease. The 2019 FASEB Science Research Conference on Protein Kinases and Protein Phosphorylation aims to highlight recent, cutting-edge findings in the field of protein phosphorylation, to bring together structural biology, biochemistry, systems biology, chemical biology, protein engineering, and medicine. This will promote cross-fertilization among these normally separate disciplines to stimulate new lines of research, as well as to enhance communication, collaboration, career advancement for the diverse scientists in the field. The ultimate goal is to advance the field to obtain better understandings of the molecular mechanisms that regulate important biological processes and facilitate the identification of critical targets for the diagnosis, prevention, treatment, and cure of human diseases. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page