FASEB SRC on Protein Kinases and Protein Phosphorylation
FASEB SRC 关于蛋白激酶和蛋白磷酸化
基本信息
- 批准号:9754337
- 负责人:
- 金额:$ 0.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-03 至 2020-06-30
- 项目状态:已结题
- 来源:
- 关键词:AreaBiochemicalBiochemistryBiological ProcessBiologyCaliforniaCardiacCareer MobilityCellular biologyChemicalsClinicalCollaborationsCommunicationDataDevelopmentDiabetes MellitusDiagnosisDisciplineDiseaseDisease modelDrug IndustryDrug TargetingEducational workshopEventFDA approvedFacultyFertilizationFosteringFundingGoalsGrowth and Development functionHumanInflammationInflammatoryKnowledgeLightingLinkMalignant NeoplasmsMediatingMedicineMetabolic DiseasesMetabolic syndromeMetabolismMethodologyMethodsMolecularNeuronsNew TerritoriesNormal CellOncogenicPhosphoric Monoester HydrolasesPhosphorylationPhosphotransferasesPlayPreventionPrincipal InvestigatorProcessProtein EngineeringProtein KinaseProtein Kinase Protein PhosphorylationReportingResearchResearch PersonnelResortRoleScienceScientistSenior ScientistSignal TransductionSiteStructureStudentsSystemSystems AnalysisSystems BiologyTechnologyTimeTranslational ResearchUnderrepresented GroupsUnderrepresented MinorityWomancareercareer developmentcell growthforginghuman diseaseimprovedin vivo Modelinnovationinsightinterestkinase inhibitormeetingsminority scientistmultidisciplinarynext generationnovelnovel anticancer drugnovel therapeuticsoncologypostersprogramsrecruitsocialspatiotemporalstructural biologysummer researchsymposiumtherapeutic developmenttherapeutic targettool
项目摘要
Program Director/Principal Investigator : Zhang, Jin
Protein phosphorylation is vitally important in the molecular communications that control cellular state and
activity. It is a dynamic process mediated by kinases and phosphatases that are precisely regulated in normal
cells, and deregulated in many human diseases, including diabetes, inflammatory disease and cancer. The
study of the protein phosphorylation machinery and its function in signaling systems is a robustly active area of
research that has driven methodological and conceptual advances and is increasingly contributing to the
development of therapeutic options. Protein kinases are frequently deregulated in cancer, and they have been
the focus of intense recent interest by the pharmaceutical industry. Indeed, most new cancer drugs approved
by the FDA in the last several years target kinases, and there are hundreds of new kinase inhibitors under
development. This strong clinical connection provides an exciting link with translational science.
In this application, we request funds to support attendance of trainees, junior faculty and traditionally
underrepresented groups at the 2019 FASEB Summer Research conference on Protein Kinases and Protein
Phosphorylation. This biennial conference started in 1983, and is an important interdisciplinary gathering that
brings together scientists with diverse expertise to advance understanding of the biochemical mechanisms and
fundamental principles of phosphorylation events – a focus that distinguishes this meeting from others that
deal with signaling networks and systems approaches. This FASEB meeting has been, and continues to be, a
primary venue for the announcement of breakthroughs in the field, and has a long-standing goal to enhance,
and disseminate, knowledge that will lead to improved therapies to target aberrant kinase activity, and protein
phosphorylation, in human disease. The 2019 FASEB Science Research Conference on Protein Kinases and
Protein Phosphorylation aims to highlight recent, cutting-edge findings in the field of protein phosphorylation, to
bring together structural biology, biochemistry, systems biology, chemical biology, protein engineering, and
medicine. This will promote cross-fertilization among these normally separate disciplines to stimulate new lines
of research, as well as to enhance communication, collaboration, career advancement for the diverse scientists
in the field. The ultimate goal is to advance the field to obtain better understandings of the molecular
mechanisms that regulate important biological processes and facilitate the identification of critical targets for
the diagnosis, prevention, treatment, and cure of human diseases.
OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page
项目负责人/主要研究者:张金
蛋白质磷酸化在控制细胞状态的分子通讯中至关重要,
活动这是一个由激酶和磷酸酶介导的动态过程,这些激酶和磷酸酶在正常细胞中被精确调节。
在许多人类疾病中,包括糖尿病、炎性疾病和癌症,这种调节是不正常的。的
研究蛋白质磷酸化机制及其在信号系统中的功能是一个非常活跃的领域,
研究推动了方法和概念的进步,并越来越多地有助于
开发治疗方案。蛋白激酶在癌症中经常失调,并且它们已经被广泛应用于癌症治疗。
制药业最近的关注焦点。事实上,大多数新的癌症药物批准
在过去的几年里,FDA已经开发了数百种新的激酶抑制剂,
发展这种强大的临床联系提供了一个令人兴奋的链接与转化科学。
在此申请中,我们要求资金支持学员,初级教师和传统的出勤率。
2019年FASEB蛋白激酶和蛋白质夏季研究会议上代表不足的群体
磷酸化。这个两年一度的会议始于1983年,是一个重要的跨学科聚会,
汇集了具有不同专业知识的科学家,以促进对生化机制的理解,
磷酸化活动的基本原则-这一重点使本次会议有别于其他会议,
处理信令网络和系统的方法。这次FASEB会议一直是,并将继续是,
宣布突破领域的主要场所,并有一个长期的目标,以提高,
和传播,知识,这将导致改进的疗法,以靶向异常激酶活性,和蛋白质
磷酸化,在人类疾病中。2019年FASEB蛋白激酶科学研究会议
蛋白质磷酸化旨在突出蛋白质磷酸化领域的最新前沿发现,
将结构生物学、生物化学、系统生物学、化学生物学、蛋白质工程和
药这将促进这些通常独立的学科之间的交叉施肥,以刺激新的品系
研究,以及加强沟通,合作,职业发展的不同科学家
在外地最终目标是推进该领域,以更好地了解分子生物学。
调节重要的生物过程和促进确定关键目标的机制,
人类疾病的诊断、预防、治疗和治愈。
OMB编号0925 - 0001/0002(2018年1月批准至2020年3月31日修订版)页码续页格式页码
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jin Zhang其他文献
Jin Zhang的其他文献
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{{ truncateString('Jin Zhang', 18)}}的其他基金
Integrating multi-omics, imaging, and longitudinal data to predict radiation response in cervical cancer
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10734702 - 财政年份:2023
- 资助金额:
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HPV genomic structure in cervical cancer radiation response and recurrence detection
HPV基因组结构在宫颈癌放射反应和复发检测中的作用
- 批准号:
10634999 - 财政年份:2023
- 资助金额:
$ 0.4万 - 项目类别:
Deep learning in cervical cancer radiogenomics
宫颈癌放射基因组学中的深度学习
- 批准号:
10643978 - 财政年份:2022
- 资助金额:
$ 0.4万 - 项目类别:
Deep learning in cervical cancer radiogenomics
宫颈癌放射基因组学中的深度学习
- 批准号:
10424854 - 财政年份:2022
- 资助金额:
$ 0.4万 - 项目类别:
HPV alternative splicing in cervical cancer radiation response
HPV选择性剪接在宫颈癌放射反应中的作用
- 批准号:
10308435 - 财政年份:2020
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HPV alternative splicing in cervical cancer radiation response
HPV选择性剪接在宫颈癌放射反应中的作用
- 批准号:
9891761 - 财政年份:2020
- 资助金额:
$ 0.4万 - 项目类别:
HPV alternative splicing in cervical cancer radiation response
HPV选择性剪接在宫颈癌放射反应中的作用
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10523104 - 财政年份:2020
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Signal Transduction by PI3K/Akt/mTOR Pathway
通过 PI3K/Akt/mTOR 途径进行信号转导
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9108384 - 财政年份:2015
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$ 0.4万 - 项目类别:
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