Signal Transduction by PI3K/Akt/mTOR Pathway

通过 PI3K/Akt/mTOR 途径进行信号转导

基本信息

  • 批准号:
    9108384
  • 负责人:
  • 金额:
    $ 30.61万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-07-10 至 2019-04-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): The signaling pathway regulated by phosphatidylinositol 3-kinase (PI3K) and the downstream serine/threonine kinase Akt (also known as protein kinase B) transduces the signals encoded by insulin and growth factors and regulates a number of processes that are critical to cell physiology. In addition to serving as a critical downstream component in the PI3K/Akt pathway, the mechanistic target of rapamycin (mTOR) also integrates signals from amino acids, stress, oxygen and energy level to impact most major cellular functions. For such key-node signaling molecules as PI3K, Akt and mTOR, which regulate multiple cellular processes, spatial compartmentalization has been suggested to be an important mechanism for achieving high signaling specificity. In particular, accumulating evidence has suggested that spatial compartmentalization is not only important for enhancing signaling specificity, it is also required for the functioning of the PI3K/Akt/mTOR signaling pathway. However, spatial regulation of PI3K/Akt/mTOR signaling is not well defined and the underlying mechanisms remain poorly understood. The overall goal of our research is to elucidate the molecular and cellular mechanisms by which the PI3K/Akt/mTOR pathway is spatially regulated. We have performed a series of preliminary studies that focus on the plasma membrane and nuclear regulation of this pathway, which led to the hypothesis that signaling activities of the PI3K/Akt/mTOR pathway are present and specifically regulated in both plasma membrane and nuclear compartments. In this proposal, building upon our preliminary findings, we will use NIH3T3 fibroblasts, 3T3 L1 adipocytes, and primary mouse adipocytes as cellular model systems, and combine biochemical and functional characterization with biosensor engineering and super-resolution fluorescence microscopy to address the following aims: 1) To investigate spatial compartmentalization of phosphoinositides.; 2) To examine cellular regulation of Akt; 3) To determine the mechanisms that regulate mTORC1 activities in subcellular compartments. Dysregulated PI3K/Akt/mTOR signaling has widespread implications for clinical conditions. In insulin-responsive tissues, the pathway plays a pivotal role for the effects of insulin, and impaired signaling through PI3K/Akt/mTOR may predispose to the development of diabetes. A mechanistic understanding of signal transduction by PI3K/Akt/mTOR is crucial to developing therapeutic approaches for these clinical conditions.


项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jin Zhang其他文献

Jin Zhang的其他文献

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{{ truncateString('Jin Zhang', 18)}}的其他基金

Integrating multi-omics, imaging, and longitudinal data to predict radiation response in cervical cancer
整合多组学、成像和纵向数据来预测宫颈癌的放射反应
  • 批准号:
    10734702
  • 财政年份:
    2023
  • 资助金额:
    $ 30.61万
  • 项目类别:
HPV genomic structure in cervical cancer radiation response and recurrence detection
HPV基因组结构在宫颈癌放射反应和复发检测中的作用
  • 批准号:
    10634999
  • 财政年份:
    2023
  • 资助金额:
    $ 30.61万
  • 项目类别:
Deep learning in cervical cancer radiogenomics
宫颈癌放射基因组学中的深度学习
  • 批准号:
    10643978
  • 财政年份:
    2022
  • 资助金额:
    $ 30.61万
  • 项目类别:
Deep learning in cervical cancer radiogenomics
宫颈癌放射基因组学中的深度学习
  • 批准号:
    10424854
  • 财政年份:
    2022
  • 资助金额:
    $ 30.61万
  • 项目类别:
HPV alternative splicing in cervical cancer radiation response
HPV选择性剪接在宫颈癌放射反应中的作用
  • 批准号:
    10308435
  • 财政年份:
    2020
  • 资助金额:
    $ 30.61万
  • 项目类别:
HPV alternative splicing in cervical cancer radiation response
HPV选择性剪接在宫颈癌放射反应中的作用
  • 批准号:
    9891761
  • 财政年份:
    2020
  • 资助金额:
    $ 30.61万
  • 项目类别:
HPV alternative splicing in cervical cancer radiation response
HPV选择性剪接在宫颈癌放射反应中的作用
  • 批准号:
    10523104
  • 财政年份:
    2020
  • 资助金额:
    $ 30.61万
  • 项目类别:
FASEB SRC on Protein Kinases and Protein Phosphorylation
FASEB SRC 关于蛋白激酶和蛋白磷酸化
  • 批准号:
    9754337
  • 财政年份:
    2019
  • 资助金额:
    $ 30.61万
  • 项目类别:
Live-cell Activity Architecture in Cancer
癌症中的活细胞活性结构
  • 批准号:
    10673027
  • 财政年份:
    2015
  • 资助金额:
    $ 30.61万
  • 项目类别:
Live-cell Activity Architecture in Cancer
癌症中的活细胞活性结构
  • 批准号:
    9319218
  • 财政年份:
    2015
  • 资助金额:
    $ 30.61万
  • 项目类别:

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