Molecular Pathology and Imaging Core

分子病理学和成像核心

• 批准号: 9762894
• 负责人: JONATHAN P KATZ
• 金额: $ 16.56万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762894
• 关键词: Biomedical Research; Cells; Collaborations; Core Facility; Country; Development; Digestive System Disorders; Doctor of Medicine; Equipment; Exposure to; Floor; Fostering; Funding; Gastrointestinal tract structure; Histology; Human Resources; Image; Individual; Institution; Laboratories; Lasers; Lead; Leadership; Light; Liver; Liver diseases; Microscope; Microscopy; Modeling; Molecular; Neurobiology; Organ; Pancreas; Pancreatic Diseases; Pennsylvania; Process; Productivity; Program Research Project Grants; Reagent; Research; Research Personnel; Research Training; Resources; Services; Sleep; Slide; Specialist; Surveys; System; Techniques; Technology; Tissue Sample; Tissues; Training; U-Series Cooperative Agreements; Universities; circadian; cost effective; experience; imaging capabilities; laser capture microdissection; live cell imaging; medical schools; member; molecular pathology; new technology; next generation sequencing; pathology imaging; programs; ranpirnase; square foot

PROJECT SUMMARY (MOLECULAR PATHOLOGY & IMAGING CORE) The Molecular Pathology and Imaging Core (MPIC) is a unique entity at the University of Pennsylvania and provides tremendous service, resources, expertise, and efficiency for investigators of the Center for Molecular Studies in Digestive and Liver Diseases (CMSDLD). The MPIC has specific expertise in processing and analyses of all tissue types relevant to the CMSDLD and includes specialized microscopes, as well as other reagents and equipment essential for the research of CMSDLD investigators; no resource with similar expertise exists on the Penn campus or in nearby institutions. In addition, by providing cost-effective approaches, the MPIC is particular beneficial to Pilot and Feasibility awardees, who receive subsidies for MPIC services, and junior investigators/Associate Members, many of whom do not yet have independent funding. Established in 1995 as part of a Program Project grant, the MPIC expanded in 1997 to serve CMSDLD investigators and, since its inception, has been heavily utilized and extremely successful, serving as a model core facility for numerous other Centers and Program Projects at the University of Pennsylvania and throughout the country. The MPIC is a key component of the CMSDLD, providing essential, routine services as well as cutting edge technologies to CMSDLD investigators. Currently comprising more than 1,000 square feet on the 9th floor of BRBII/III, the MPIC is lead by an experienced Director and Technical Director and supported by a highly-trained staff. Moreover, working with other Cores and Centers, the MPIC expands the resources and services available to CMSDLD investigators, and since the last competitive renewal of this application, the MPIC has continued to incorporate and integrate new services and technologies. Additionally, the MPIC promotes new and exciting collaborations and research directions. Overall, the MPIC serves the CMSDLD by pursuing the following two interrelated Specific Aims: (1) To enhance the efficiency and productivity of CMSDLD members by providing specialized technical resources, services, and expertise in histology, pathology, and imaging of the digestive tract, liver, and pancreas; and (2) To integrate new technologies that advance research and discovery for studies of digestive, liver, and pancreatic diseases by both surveying and anticipating the needs of CMSDLD members. As such, the MPIC provides exceptional utility, quality, value, experience, service, and commitment to the CMSDLD.

项目摘要（分子病理学和成像核心） 分子病理学和成像核心 (MPIC) 是宾夕法尼亚大学的一个独特实体， 为分子中心的研究人员提供了大量的服务、资源、专业知识和效率 消化和肝脏疾病研究 (CMSDLD)。 MPIC 在处理和 分析与 CMSDLD 相关的所有组织类型，包括专用显微镜以及其他 CMSDLD 研究人员研究必需的试剂和设备；没有类似的资源 宾夕法尼亚大学校园或附近的机构拥有专业知识。此外，通过提供具有成本效益的 方法中，MPIC 对于获得 MPIC 补贴的试点和可行性获奖者特别有利 服务和初级研究员/准会员，其中许多人尚未获得独立的资助。 MPIC 成立于 1995 年，作为计划项目拨款的一部分，并于 1997 年扩大规模，为 CMSDLD 提供服务 自成立以来，已被大量利用并取得了巨大成功，成为典范 宾夕法尼亚大学许多其他中心和项目的核心设施 全国各地。 MPIC 是 CMSDLD 的关键组成部分，提供基本的日常服务 以及向 CMSDLD 研究人员提供尖端技术。目前占地1000多平方米 MPIC 位于 BRBII/III 9 楼，由经验丰富的总监和技术总监领导， 由训练有素的员工提供支持。此外，通过与其他核心和中心合作，MPIC 扩展了 CMSDLD 调查人员可获得的资源和服务，以及自上次竞争性更新以来 应用程序中，MPIC 不断整合和集成新的服务和技术。此外， MPIC 促进新的、令人兴奋的合作和研究方向。总体而言，MPIC 服务于 CMSDLD 通过追求以下两个相互关联的具体目标： (1) 提高效率和 通过提供专业技术资源、服务和专业知识，提高 CMSDLD 成员的生产力 消化道、肝脏和胰腺的组织学、病理学和成像； (2) 整合新的 促进消化、肝脏和胰腺疾病研究和发现的技术 调查并预测 CMSDLD 成员的需求。因此，MPIC 提供了卓越的 实用性、质量、价值、经验、服务以及对 CMSDLD 的承诺。