Core Facilities for Vision Research

视觉研究核心设施

• 批准号: 9762112
• 负责人: MICHAEL E. GOLDBERG
• 金额: $ 80万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762112
• 关键词: Animals; Behavior; Biochemical; Blindness; Brain; Clinical; Collaborations; Communities; Computer Hardware; Computer software; Computers; Core Facility; Core Grant; Custom; Data; Data Analyses; Data Storage and Retrieval; Databases; Development; Disease; Drosophila genus; Electronics; Emergency Situation; Equipment; Eye; Eye Development; Fluorescence Microscopy; Functional disorder; Funding; Funding Mechanisms; Genetic; Genetic study; Glaucoma; Grant; Health Insurance Portability and Accountability Act; Histologic; Histology; Human; Image; Individual; Institutes; Laboratories; Light; Macular degeneration; Maintenance; Microscopic; Microscopy; Modification; Mus; Myopia; National Eye Institute; Neurosciences; Oryctolagus cuniculus; Patients; Postdoctoral Fellow; Privatization; Process; Qualifying; Research; Research Personnel; Research Project Grants; Research Support; Resources; Retinal; Retinal Diseases; Rodent; Scientist; Security; Services; System; Techniques; Technology; Time; Training; United States National Institutes of Health; Universities; Vision; Vision research; Visual; Work; base; clinical database; design; fluorescence microscope; in vivo; in vivo imaging; instrument; instrumentation; light microscopy; member; microscopic imaging; neurophysiology; new technology; ocular angiogenesis; oculomotor behavior; programs; repaired; student training; tissue culture; tissue preparation; vision development; vision science; visual neuroscience

Project Summary/Abstract Columbia University has a large and vibrant vision research community supported by the National Eye Institute, with 22 qualifying R01 grants and 44 vision scientists in all. Vision research at Columbia ranges across a gamut of topics, from genetic studies of retinal and visual brain development in Drosophila and mice to studies of human retinal disease. Computational, neurophysiological, light microscopic, genetic, biochemical, and clinical techniques focus on a range of problems including the development of the eye and the visual brain, the mechanisms of ocular angiogenesis, the systems neuroscience of visual and oculomotor behavior, and the pathophysiology, genetics, and treatment of retinal diseases such as macular degeneration, myopia, and glaucoma. To support this vision research we are applying to renew our National Eye Institute grant 1P30 EY019007, which will continue to support a set of Core Facilities for Vision Research and enable services that could not be provided by individual research grants. The grant supports three research cores: i) an Instrumentation Fabrication and Design Core that designs and builds custom equipment; ii) a Computer Support Core that performs support and maintenance for the hundreds of computers, including an X-grid cluster and real-time laboratory computer-based interface used by the vision research community; and iii) a Histology and Imaging Core, which provides histological, in vivo, and fluorescent microscopy services. The grant not only supports currently funded investigators with NEI R01s, but also underwrites the work of vision scientists supported by other NEI funding mechanisms, other NIH institutes, and young investigators gathering data in order to submit their first NEI grants. This grant facilitates collaboration among members of the Columbia vision research community, and encourages scientists not currently engaged in vision research to use their expertise in problems related to vision.

项目概要/摘要 哥伦比亚大学拥有一个由国家眼科支持的大型且充满活力的视觉研究社区 研究所，共有 22 名合格的 R01 资助人和 44 名视觉科学家。哥伦比亚山脉的视觉研究 涵盖了一系列主题，从果蝇视网膜和视觉大脑发育的遗传学研究到 老鼠研究人类视网膜疾病。计算、神经生理学、光显微镜、遗传学、 生物化学和临床技术专注于一系列问题，包括眼睛的发育 和视觉大脑、眼部血管生成机制、视觉和视觉系统神经科学 动眼行为，以及视网膜疾病的病理生理学、遗传学和治疗，例如 黄斑变性、近视和青光眼。为了支持这项愿景研究，我们正在申请更新 我们的国家眼科研究所拨款 1P30 EY019007，它将继续支持一套核心设施 愿景研究并提供个人研究资助无法提供的服务。补助金 支持三个研究核心：i) 设计和构建仪器制造和设计核心 定制设备； ii) 计算机支持核心，为数百台计算机提供支持和维护 计算机，包括 X 网格集群和实验室使用的基于计算机的实时界面 视觉研究社区； iii) 组织学和成像核心，提供组织学、体内和 荧光显微镜服务。该补助金不仅支持目前由 NEI 资助的研究人员 R01s，还资助由其他 NEI 资助机制支持的视觉科学家的工作， 其他 NIH 机构和年轻的研究人员收集数据以提交他们的第一笔 NEI 资助。这 赠款促进哥伦比亚视觉研究界成员之间的合作，以及 鼓励目前未从事视觉研究的科学家利用他们的专业知识解决相关问题 到愿景。