Core Facilities for Vision Research

视觉研究核心设施

• 批准号: 10016318
• 负责人: MICHAEL E. GOLDBERG
• 金额: $ 80万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10016318
• 关键词: Animals; Behavior; Biochemical; Blindness; Brain; Clinical; Collaborations; Communities; Computer Hardware; Computer software; Computers; Core Facility; Core Grant; Custom; Data; Data Analyses; Data Storage and Retrieval; Databases; Development; Disease; Drosophila genus; Electronics; Emergency Situation; Equipment; Eye; Eye Development; Fluorescence Microscopy; Functional disorder; Funding; Funding Mechanisms; Genetic; Genetic study; Glaucoma; Grant; Health Insurance Portability and Accountability Act; Histologic; Histology; Human; Image; Individual; Institutes; Laboratories; Light; Macular degeneration; Maintenance; Microscopic; Microscopy; Modification; Mus; Myopia; National Eye Institute; Neurosciences; Oryctolagus cuniculus; Patients; Postdoctoral Fellow; Privatization; Process; Qualifying; Research; Research Personnel; Research Project Grants; Research Support; Resources; Retina; Retinal Diseases; Rodent; Scientist; Security; Services; System; Techniques; Technology; Time; Training; United States National Institutes of Health; Universities; Vision; Vision research; Visual; Work; base; clinical database; design; fluorescence microscope; in vivo; in vivo imaging; instrument; instrumentation; light microscopy; member; microscopic imaging; neurophysiology; new technology; ocular angiogenesis; oculomotor behavior; programs; repaired; student training; tissue culture; tissue preparation; vision development; vision science

Project Summary/Abstract Columbia University has a large and vibrant vision research community supported by the National Eye Institute, with 22 qualifying R01 grants and 44 vision scientists in all. Vision research at Columbia ranges across a gamut of topics, from genetic studies of retinal and visual brain development in Drosophila and mice to studies of human retinal disease. Computational, neurophysiological, light microscopic, genetic, biochemical, and clinical techniques focus on a range of problems including the development of the eye and the visual brain, the mechanisms of ocular angiogenesis, the systems neuroscience of visual and oculomotor behavior, and the pathophysiology, genetics, and treatment of retinal diseases such as macular degeneration, myopia, and glaucoma. To support this vision research we are applying to renew our National Eye Institute grant 1P30 EY019007, which will continue to support a set of Core Facilities for Vision Research and enable services that could not be provided by individual research grants. The grant supports three research cores: i) an Instrumentation Fabrication and Design Core that designs and builds custom equipment; ii) a Computer Support Core that performs support and maintenance for the hundreds of computers, including an X-grid cluster and real-time laboratory computer-based interface used by the vision research community; and iii) a Histology and Imaging Core, which provides histological, in vivo, and fluorescent microscopy services. The grant not only supports currently funded investigators with NEI R01s, but also underwrites the work of vision scientists supported by other NEI funding mechanisms, other NIH institutes, and young investigators gathering data in order to submit their first NEI grants. This grant facilitates collaboration among members of the Columbia vision research community, and encourages scientists not currently engaged in vision research to use their expertise in problems related to vision.

项目摘要/摘要 哥伦比亚大学有一个庞大而充满活力的视力研究社区，得到了国家眼的支持 研究所，共有22名合格的R01奖助金和44名视觉科学家。哥伦比亚大学范围内的视觉研究 来自对果蝇视网膜和视觉大脑发育的遗传学研究，以及 老鼠对人类视网膜疾病的研究。计算，神经生理学，光学显微镜，遗传学， 生化和临床技术专注于一系列问题，包括眼睛的发育 和视觉大脑，眼睛血管生成的机制，视觉和系统神经科学 眼球运动行为，以及视网膜疾病的病理生理学、遗传学和治疗 黄斑变性、近视和青光眼。为了支持这一愿景研究，我们正在申请续签 我们的国家眼科研究所拨款1P30 EY019007，将继续支持一套核心设施，用于 愿景研究，并支持个人研究拨款无法提供的服务。助学金 支持三个研究核心：i)设计和建造仪器制造和设计核心 定制设备；ii)为数百台计算机执行支持和维护的计算机支持核心 计算机，包括X-GRID集群和实验室使用的实时计算机界面 视觉研究社区；以及iii)组织学和成像核心，它提供组织学、活体和 荧光显微镜服务。这笔拨款不仅支持目前由NEI资助的研究人员 R01，但也支持视觉科学家的工作，由其他NEI资助机制支持， 其他NIH研究所，以及年轻的研究人员收集数据，以便提交他们的第一笔NEI赠款。这 格兰特促进哥伦比亚视觉研究社区成员之间的合作，以及 鼓励目前没有从事视觉研究的科学家在相关问题上运用他们的专业知识 为愿景干杯。