Core Facilities for Vision Research

项目概要/摘要 哥伦比亚大学有一个由国家眼支持的大型和充满活力的视觉研究社区 研究所，共有22名合格的R 01赠款和44名视觉科学家。哥伦比亚靶场的视觉研究 从果蝇视网膜和视觉大脑发育的遗传研究， 小鼠用于人类视网膜疾病的研究。计算，神经生理，光学显微镜，遗传， 生物化学和临床技术集中在一系列问题上，包括眼睛的发育 以及视觉脑、眼部血管生成机制、视觉和视觉系统神经科学 眼科行为，以及视网膜疾病的病理生理学、遗传学和治疗， 黄斑变性、近视和青光眼。为了支持这项视觉研究，我们正在申请更新 我们的国家眼科研究所拨款1 P30 EY 019007，将继续支持一套核心设施， 愿景研究，并使个人研究赠款无法提供的服务。授出 支持三个研究核心：i）仪器制造和设计核心， 定制设备; ii）计算机支持核心，为数百个 包括一个X-grid集群和实时实验室计算机接口， 视觉研究社区;和iii）组织学和成像核心，其提供组织学、体内和 荧光显微镜服务。该赠款不仅支持目前资助的NEI研究人员 R 01 s，但也承保由其他NEI资助机制支持的视觉科学家的工作， 其他国家卫生研究院的研究机构，以及年轻的研究人员收集数据，以提交他们的第一个NEI赠款。这 赠款促进了哥伦比亚视觉研究社区成员之间的合作， 鼓励目前没有从事视觉研究的科学家利用他们的专业知识解决相关问题， 到视觉。

Project Summary/Abstract Columbia University has a large and vibrant vision research community supported by the National Eye Institute, with 22 qualifying R01 grants and 44 vision scientists in all. Vision research at Columbia ranges across a gamut of topics, from genetic studies of retinal and visual brain development in Drosophila and mice to studies of human retinal disease. Computational, neurophysiological, light microscopic, genetic, biochemical, and clinical techniques focus on a range of problems including the development of the eye and the visual brain, the mechanisms of ocular angiogenesis, the systems neuroscience of visual and oculomotor behavior, and the pathophysiology, genetics, and treatment of retinal diseases such as macular degeneration, myopia, and glaucoma. To support this vision research we are applying to renew our National Eye Institute grant 1P30 EY019007, which will continue to support a set of Core Facilities for Vision Research and enable services that could not be provided by individual research grants. The grant supports three research cores: i) an Instrumentation Fabrication and Design Core that designs and builds custom equipment; ii) a Computer Support Core that performs support and maintenance for the hundreds of computers, including an X-grid cluster and real-time laboratory computer-based interface used by the vision research community; and iii) a Histology and Imaging Core, which provides histological, in vivo, and fluorescent microscopy services. The grant not only supports currently funded investigators with NEI R01s, but also underwrites the work of vision scientists supported by other NEI funding mechanisms, other NIH institutes, and young investigators gathering data in order to submit their first NEI grants. This grant facilitates collaboration among members of the Columbia vision research community, and encourages scientists not currently engaged in vision research to use their expertise in problems related to vision.