Core Facilities for Vision Research

视觉研究核心设施

基本信息

批准号：
10016318
负责人：
MICHAEL E. GOLDBERG
金额：
$ 80万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10016318
关键词：
Animals Behavior Biochemical Blindness Brain Clinical Collaborations Communities Computer Hardware Computer software Computers Core Facility Core Grant Custom Data Data Analyses Data Storage and Retrieval Databases Development Disease Drosophila genus Electronics Emergency Situation Equipment Eye Eye Development Fluorescence Microscopy Functional disorder Funding Funding Mechanisms Genetic Genetic study Glaucoma Grant Health Insurance Portability and Accountability Act Histologic Histology Human Image Individual Institutes Laboratories Light Macular degeneration Maintenance Microscopic Microscopy Modification Mus Myopia National Eye Institute Neurosciences Oryctolagus cuniculus Patients Postdoctoral Fellow Privatization Process Qualifying Research Research Personnel Research Project Grants Research Support Resources Retina Retinal Diseases Rodent Scientist Security Services System Techniques Technology Time Training United States National Institutes of Health Universities Vision Vision research Visual Work base clinical database design fluorescence microscope in vivo in vivo imaging instrument instrumentation light microscopy member microscopic imaging neurophysiology new technology ocular angiogenesis oculomotor behavior programs repaired student training tissue culture tissue preparation vision development vision science

项目摘要

Project Summary/Abstract Columbia University has a large and vibrant vision research community supported by the National Eye Institute, with 22 qualifying R01 grants and 44 vision scientists in all. Vision research at Columbia ranges across a gamut of topics, from genetic studies of retinal and visual brain development in Drosophila and mice to studies of human retinal disease. Computational, neurophysiological, light microscopic, genetic, biochemical, and clinical techniques focus on a range of problems including the development of the eye and the visual brain, the mechanisms of ocular angiogenesis, the systems neuroscience of visual and oculomotor behavior, and the pathophysiology, genetics, and treatment of retinal diseases such as macular degeneration, myopia, and glaucoma. To support this vision research we are applying to renew our National Eye Institute grant 1P30 EY019007, which will continue to support a set of Core Facilities for Vision Research and enable services that could not be provided by individual research grants. The grant supports three research cores: i) an Instrumentation Fabrication and Design Core that designs and builds custom equipment; ii) a Computer Support Core that performs support and maintenance for the hundreds of computers, including an X-grid cluster and real-time laboratory computer-based interface used by the vision research community; and iii) a Histology and Imaging Core, which provides histological, in vivo, and fluorescent microscopy services. The grant not only supports currently funded investigators with NEI R01s, but also underwrites the work of vision scientists supported by other NEI funding mechanisms, other NIH institutes, and young investigators gathering data in order to submit their first NEI grants. This grant facilitates collaboration among members of the Columbia vision research community, and encourages scientists not currently engaged in vision research to use their expertise in problems related to vision.

项目摘要/摘要哥伦比亚大学拥有一个庞大且充满活力的视力研究社区，由国家眼睛支持研究所，共有22个合格的R01赠款和44位视力科学家。哥伦比亚山脉的视觉研究遍布一系列主题，从果蝇和视觉脑发育的遗传研究小鼠研究人类视网膜疾病。计算，神经生理学，光学显微镜，遗传学，生化和临床技术集中于一系列问题，包括眼睛的发展以及视觉大脑，眼血管生成的机制，视觉和视觉和眼球行为以及视网膜疾病的病理生理学，遗传学和治疗黄斑变性，近视和青光眼。为了支持这项愿景研究，我们正在申请更新我们的国家眼科研究所授予1P30 EY019007，该公司将继续支持一套核心设施视力研究和启用个人研究赠款无法提供的服务。赠款支持三个研究核心：i）设计和建造的仪器制造和设计核心定制设备； ii）一个计算机支持核心，可为数百人提供支持和维护计算机，包括X网格群和基于实验室计算机的实时计算机接口视觉研究社区； iii）一种组织学和成像核，可提供组织学，体内和荧光显微镜服务。该赠款不仅支持当前资助的NEI的调查员 R01，但也承销了其他NEI资金机制支持的视觉科学家的工作，其他NIH机构和年轻的调查人员收集数据以提交他们的第一份NEI补助金。这授予促进哥伦比亚视觉研究社区成员之间的合作，鼓励科学家目前尚未从事愿景研究，将其专业知识用于相关问题视力。