权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Blood Flow Velocimetry Using Digital Subtraction Angiography

使用数字减影血管造影进行血流速度测量

基本信息

批准号：
9763361
负责人：
BIPIN SINGH
金额：
$ 57.25万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9763361
关键词：
Address Air Algorithms Aneurysm Animal Testing Animals Area Arteriographies Blood Blood Flow Velocity Blood Pressure Blood capillaries Blood flow Cardiovascular Diseases Cerebrovascular Disorders Characteristics Clinical Complex Contrast Media Data Developed Countries Developing Countries Development Diagnosis Diagnostic Diagnostic radiologic examination Digital Subtraction Angiography Disease Doctor of Medicine Economics Ensure Evaluation Foundations Geometry Goals Gold Health Healthcare Image Image Enhancement Imaging Techniques Individual Intervention Investments Iowa Knowledge Laboratories Legal patent Letters Light Maps Measurement Measures Mechanical Stress Medical Mission Modality Modeling Monitor Morbidity - disease rate Mus Noise Operative Surgical Procedures Patients Personal Satisfaction Phase Physiologic pulse Preparation Prevention Procedures Property Protocols documentation Reporting Research Resolution Roentgen Rays Savings Signal Transduction Site Source Speed Stream System Technology Testing Therapeutic Time Translating Tube United States National Institutes of Health Universities Vascular Diseases Vascular System Velocimetries Water Width Work Yang base blood flow measurement brain arteriovenous malformations charge coupled device camera clinical Diagnosis clinical practice commercialization cost design dynamic system evaluation/testing hemodynamics image processing imager imaging detector improved in vivo in vivo imaging system innovation innovative technologies instrumentation interest knowledge base medical schools metrology mortality novel off-patent operation particle phase 2 designs professor programs sensor shear stress simulation success temporal measurement tool treatment planning

项目摘要

PROJECT SUMMARY Diseases in the vascular system are still the leading cause of mortality and morbidity in developed countries despite considerable therapeutic progress in recent years. Blood flow velocity provides critical information needed for the diagnosis of vascular diseases, planning of interventional surgery treatment, and monitoring of endovascular treatment of brain arteriovenous malformations. The present lack of knowledge of flow characteristics, arising from the limited temporal and spatial resolution and limited accuracies of the current metrology modalities, averts understanding of the underlying hemodynamics and its correlation with multiple cerebrovascular diseases. To address issues with the current instrumentation, we are developing an ultrafast, high-resolution X-ray blood flow velocimetry system that will provide real time in-vivo quantitative blood velocity maps in the endovascular system. The envisioned system utilizes three transformational technologies; 1) an intense, low cost, pulsed X-ray source with pulse widths down to microseconds and inter-pulse durations of tens of microseconds, 2) an ultrafast X-ray imager with high spatial resolution, large active area, and wide dynamic range, and 3) an X-ray to light converter that overcomes the afterglow and hysteresis limitations of the current high resolution sensors. The system will enable inexpensive digital subtraction angiography (DSA) that can recover precise velocity distribution inside of the vascular systems, especially for complex geometries, making it a unique technology that can be immediately translated into clinical practice. The Phase I research has unequivocally demonstrated the feasibility of developing the proposed system for dynamic blood flow measurements through laboratory experimentation and extensive simulation work. A detailed design of the Phase II system has been accomplished and system evaluation plans have been developed. Specifically, during Phase I we have identified six beta test sites where the Phase II system will be evaluated for various medical applications, the data from which will form a firm foundation for the Phase III commercialization. Considering the commercial potential of the innovative technologies we have filed a US patent application based on the work done so far. This project is highly relevant to NIH's mission because the precise real-time assessment of blood velocities will lead to more educated therapeutic decisions which could save more lives, improve health, and reduce operation cost. The expanded knowledge base will enhance the Nation's economic well-being and ensure a continued high return on the public investment in research.

项目摘要血管系统疾病仍然是发达国家死亡率和发病率的主要原因尽管近年来在治疗上取得了相当大的进展。血流速度提供了关键信息血管疾病的诊断、介入手术治疗的计划以及脑动静脉畸形的血管内治疗。目前对心流的认识不足由于有限的时间和空间分辨率以及电流的有限准确性，计量方式，避免了解基础的血液动力学及其与多个血管疾病为了解决当前仪器的问题，我们正在开发一种超快，高分辨率的X射线血流速度测量系统，其将在所述血液流动中提供真实的实时体内定量血流速度图。血管内系统所设想的系统利用三种转型技术：1）一种密集的、低成本的脉冲X射线源，脉冲宽度低至微秒，脉冲间持续时间为数十微秒，2）具有高空间分辨率、大有效面积和宽动态的超快X射线成像仪范围，以及3）克服电流的余辉和滞后限制的X射线到光转换器高分辨率传感器该系统将使廉价的数字减影血管造影术（DSA），恢复血管系统内部的精确速度分布，特别是对于复杂的几何形状，这是一项独特的技术，可以立即转化为临床实践。第一阶段的研究已明确证明发展拟议系统的可行性通过实验室实验和广泛的模拟工作进行动态血流测量。一第二阶段系统的详细设计已经完成，系统评估计划已经完成，开发具体来说，在第一阶段，我们已经确定了六个测试地点，第二阶段系统将在那里进行。对各种医疗应用进行评估，从中获得的数据将为第三阶段奠定坚实的基础商业化考虑到创新技术的商业潜力，专利申请基于迄今为止所做的工作。该项目与NIH的使命高度相关，因为血液的精确实时评估速度将导致更多的教育治疗决定，可以挽救更多的生命，改善健康，降低运行成本。扩大的知识基础将提高国家的经济福祉，并确保公共研究投资的持续高回报。