Photonic Bandgap Structures for Improved Timing and Spatial Resolution in PET Det

用于提高 PET 检测中的定时和空间分辨率的光子带隙结构

基本信息

批准号：
8001023
负责人：
BIPIN SINGH
金额：
$ 18万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2012-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8001023
关键词：
Affect Area Businesses Cerium Characteristics Collaborations Collection Coupled Coupling Detection Development Devices Digital Mammography Digital Radiography Emission-Computed Tomography Environment Evaluation Event Functional Imaging Gel Goals LSO crystal Laboratories Length Light Lighting Liquid substance Lutetium Measurement Measures Mechanics Medical Technology Methodology Nanostructures Optics Outcome Output Patients Pennsylvania Performance Periodicity Phase Philadelphia Photons Physics Plague Positron-Emission Tomography Process Production Property Quantum Dots Radiation Radiology Specialty Refractive Indices Reporting Research Resolution Resources Roentgen Rays Semiconductors Silicon Solutions Source Specific qualifier value Staging Structure Surface System Techniques Technology Testing Time Travel Tube Universities Work Writing X-Ray Computed Tomography base cancer diagnosis commercial application density design detector electron beam lithography gallium arsenide imaging modality improved indexing instrumentation interest light emission molecular imaging nano nanofabrication nanoimprint lithography novel novel strategies photomultiplier photonics product development professor public health relevance quantum response self assembly sensor simulation solid state statistics time use tool transmission process

项目摘要

DESCRIPTION (provided by applicant): Scintillation crystals coupled to photomultiplier tubes or silicon diodes are the most common detectors for X-ray/3-ray detection. Imaging modalities such as positron emission tomography (PET), single photon emission computed tomography (SPECT), digital radiography (including digital mammography) and X-ray CT are critically important for cancer diagnosis, staging, treatment tracking and research. High resolution and high efficiency detectors used in imaging modalities such as PET widely use high density, high refractive index scintillators such as cerium-doped lutetium oxyorthosilicate (LSO: Ce). When such high refractive index scintillators are coupled to detectors such as photomultiplier tubes (PMT) or avalanche photodiodes (APD), the mismatch in the refractive index of the scintillator and the detector cause only a small fraction of the light generated within the scintillator to exit the surface of the scintillator, and thereby be sensed by the photodetector. The use of a coupling fluid or gel between the scintillator and the detector helps only marginally. The proposed research will use recent advancements in nanofabrication techniques for creating photonic band gap structures to enhance the light extraction efficiency of scintillators, thereby improving the time and energy resolutions of PET detectors. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE Scintillation crystals coupled to photomultiplier tubes or silicon diodes are the most common detectors for X-ray/3-ray detection. High density, high refractive index scintillators currently used in positron emission tomography (PET) detectors are often plagued by an inefficient extraction of the scintillation light that results in inaccuracy (often significant) in event coincidence timing sufficient to affect spatial resolution. The goal of the proposed research is to demonstrate the feasibility of using novel photonic band gap structures to improve timing and spatial resolution in PET detectors by the efficient extraction of scintillation light from such high density, high refractive index scintillators.

描述（由申请人提供）：闪烁晶体耦合到光电倍增管或硅二极管是X射线/3射线检测的最常见检测器。诸如正电子发射断层扫描（PET），单光子发射计算机断层扫描（SPECT），数字X线摄影（包括数字乳房X线摄影）和X射线CT等成像模态对于癌症诊断，分期，治疗跟踪和研究至关重要。高分辨率和高效率检测器用于成像方式（例如PET），例如PET广泛使用高密度，高折射率闪光灯，例如掺杂的含氧含氧硫酸盐（LSO：CE）。当将如此高的折射率闪光灯与探测器耦合到诸如光电倍增管（PMT）或雪崩光电二极管（APD）之类的探测器时，闪烁器的折射率和检测器的折射率不匹配仅导致闪光灯造成的光层的一小部分，从而使scintillator的一小部分产生。闪烁器和检测器之间使用耦合流体或凝胶的使用仅有助于略有帮助。拟议的研究将使用纳米制造技术的最新进步来创建光子带隙结构，以提高闪烁体的光提取效率，从而改善宠物探测器的时间和能量分辨率。公共卫生相关性：与光电倍增管或硅二极管结合的项目叙事闪烁晶体是X射线/3射线检测的最常见检测器。当前在正电子发射断层扫描（PET）探测器中使用的高密度，高折射率闪烁体通常会因闪烁光的效率低下而困扰，从而导致不准确（通常是显着）在事件上的重合时机，足以影响空间分辨率。拟议的研究的目的是证明使用新型光子带隙结构通过有效提取闪烁光的高密度，高折射率闪光灯来提高宠物探测器中的时间和空间分辨率的可行性。