Photonic Bandgap Structures for Improved Timing and Spatial Resolution in PET Det

用于提高 PET 检测中的定时和空间分辨率的光子带隙结构

• 批准号: 8001023
• 负责人: BIPIN SINGH
• 金额: $ 18万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8001023
• 关键词: Affect; Area; Businesses; Cerium; Characteristics; Collaborations; Collection; Coupled; Coupling; Detection; Development; Devices; Digital Mammography; Digital Radiography; Emission-Computed Tomography; Environment; Evaluation; Event; Functional Imaging; Gel; Goals; LSO crystal; Laboratories; Length; Light; Lighting; Liquid substance; Lutetium; Measurement; Measures; Mechanics; Medical Technology; Methodology; Nanostructures; Optics; Outcome; Output; Patients; Pennsylvania; Performance; Periodicity; Phase; Philadelphia; Photons; Physics; Plague; Positron-Emission Tomography; Process; Production; Property; Quantum Dots; Radiation; Radiology Specialty; Refractive Indices; Reporting; Research; Resolution; Resources; Roentgen Rays; Semiconductors; Silicon; Solutions; Source; Specific qualifier value; Staging; Structure; Surface; System; Techniques; Technology; Testing; Time; Travel; Tube; Universities; Work; Writing; X-Ray Computed Tomography; base; cancer diagnosis; commercial application; density; design; detector; electron beam lithography; gallium arsenide; imaging modality; improved; indexing; instrumentation; interest; light emission; molecular imaging; nano; nanofabrication; nanoimprint lithography; novel; novel strategies; photomultiplier; photonics; product development; professor; public health relevance; quantum; response; self assembly; sensor; simulation; solid state; statistics; time use; tool; transmission process

DESCRIPTION (provided by applicant): Scintillation crystals coupled to photomultiplier tubes or silicon diodes are the most common detectors for X-ray/3-ray detection. Imaging modalities such as positron emission tomography (PET), single photon emission computed tomography (SPECT), digital radiography (including digital mammography) and X-ray CT are critically important for cancer diagnosis, staging, treatment tracking and research. High resolution and high efficiency detectors used in imaging modalities such as PET widely use high density, high refractive index scintillators such as cerium-doped lutetium oxyorthosilicate (LSO: Ce). When such high refractive index scintillators are coupled to detectors such as photomultiplier tubes (PMT) or avalanche photodiodes (APD), the mismatch in the refractive index of the scintillator and the detector cause only a small fraction of the light generated within the scintillator to exit the surface of the scintillator, and thereby be sensed by the photodetector. The use of a coupling fluid or gel between the scintillator and the detector helps only marginally. The proposed research will use recent advancements in nanofabrication techniques for creating photonic band gap structures to enhance the light extraction efficiency of scintillators, thereby improving the time and energy resolutions of PET detectors. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE Scintillation crystals coupled to photomultiplier tubes or silicon diodes are the most common detectors for X-ray/3-ray detection. High density, high refractive index scintillators currently used in positron emission tomography (PET) detectors are often plagued by an inefficient extraction of the scintillation light that results in inaccuracy (often significant) in event coincidence timing sufficient to affect spatial resolution. The goal of the proposed research is to demonstrate the feasibility of using novel photonic band gap structures to improve timing and spatial resolution in PET detectors by the efficient extraction of scintillation light from such high density, high refractive index scintillators.

描述（由申请人提供）：与光电倍增管或硅二极管耦合的闪烁晶体是最常见的X射线/3射线探测器。成像模式，如正电子发射断层扫描（PET），单光子发射计算机断层扫描（SPECT），数字放射摄影（包括数字乳腺摄影）和X射线CT是癌症诊断，分期，治疗跟踪和研究至关重要。 在诸如PET的成像模态中使用的高分辨率和高效率探测器广泛使用高密度、高折射率的反射器，诸如铈掺杂的氧正硅酸镥（LSO：Ce）。当这样的高折射率闪烁器耦合到诸如光电倍增管（PMT）或雪崩光电二极管（APD）的检测器时，闪烁器和检测器的折射率的失配仅导致闪烁器内生成的光的一小部分离开闪烁器的表面，并且由此被光电检测器感测。在闪烁体和检测器之间使用耦合流体或凝胶仅略微有所帮助。拟议的研究将利用纳米纤维技术的最新进展来创建光子带隙结构，以提高光吸收器的光提取效率，从而提高PET探测器的时间和能量分辨率。 公共卫生相关性： 项目叙述 闪烁晶体耦合到光电倍增管或硅二极管是用于X射线/3射线检测的最常见的检测器。目前在正电子发射断层摄影（PET）探测器中使用的高密度、高折射率闪烁器经常受到闪烁光的低效提取的困扰，这导致事件符合定时的不准确性（通常是显著的），足以影响空间分辨率。所提出的研究的目标是证明使用新型光子带隙结构的可行性，以提高PET探测器的时间和空间分辨率的有效提取闪烁光从这样的高密度，高折射率的闪烁器。