Point of Care Elastographic Sonoangiography (eSA)

护理点弹性超声血管造影 (eSA)

基本信息

  • 批准号:
    9768247
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-10-01 至 2021-09-30
  • 项目状态:
    已结题

项目摘要

ABSTRACT Our nation’s veterans are at a high risk for developing Chronic Kidney Disease (CKD) with rates of mortality and morbidity that are extremely high. CKD progressing to End Stage Renal Disease (ESRD) is a disabling condition resulting in patients requiring hemodialysis thrice weekly to maintain life. Functional independence on hemodialysis requires a reliable and well-functioning vascular access to connect to the dialysis machine for treatments. Vascular access is crucial to the treatments necessary for hemodialysis patients. Due to their reliability, longevity, and lower complication rates, autogenous arteriovenous fistulas – surgically created connections between arteries and veins – have become increasingly prominent over other forms of vascular access. However, the uncertainty associated with fistula maturation has caused undue cost, risk, and stress to patients already undergoing significant medical procedures. Furthermore, fistula dysfunction in the dialysis unit impedes stable effective dialysis, creates undue psychological stress in patients, in addition to increasing the cost of medical care. Currently no system exists to directly and noninvasively measure the underlying causes of vascular remodeling during fistula maturation, or provides comprehensive diagnosis of fistula dysfunction at the bedside. We propose to build and clinically validate an ultrasound diagnostic platform – referred to as the Point of Care Elastographic Sono-Angiography (eSA) that has unprecedented temporal and spatial resolution to identify vessel wall edges and measure vessel size, elastic properties, and blood-wall shear rate during the cardiac cycles, and 3D mapping of the vascular anatomy at the point of care. After validating this tool both in vitro (through phantom studies on simple and realistic fistula geometries) and in vivo (clinical study conducted on hemodialysis patients pre- and post-fistula creation), we plan to release the software as an open platform tool for researchers. This software tool will be useful for pre-operative planning and post-operative assessment to guide decisions for angioplasty and surgical revision. Given the ubiquity and noninvasive nature of ultrasound imaging and the broad open access with which we plan to release this tool, this proposal can radically accelerate safe and effective ultrasound diagnostic methods for fistula optimization. In addition, given the generalizability to other peripheral vascular systems (carotid, extremities) this system has the potential to optimize vascular diagnostics and thereby improve the functional capacity of veterans suffering from peripheral and cerebral arterial disease. By validating this technology in the dialysis fistula setting, this project will lay the foundation for further clinical research applied to expanded clinical indications in vascular medicine in the future.
摘要 我们国家的退伍军人患慢性肾脏病(CKD)的风险很高,死亡率很高, 发病率非常高。CKD进展为终末期肾病(ESRD)是一种致残性疾病 导致患者需要每周三次血液透析来维持生命。功能独立于 血液透析需要可靠且功能良好的血管通路以连接到透析机, 治疗。血管通路对于血液透析患者的必要治疗至关重要。由于其 可靠性、寿命和较低的并发症发生率,自体动静脉内瘘-手术创建 动脉和静脉之间的连接-与其他形式的血管连接相比, access.然而,与瘘管成熟相关的不确定性已经导致了过度的成本、风险和压力, 已经在接受重大医疗程序的患者。此外,透析室的瘘管功能障碍 阻碍稳定有效的透析,除了增加成本之外,还在患者中产生不适当的心理压力 医疗保健的重要性。目前还不存在直接和非侵入性地测量肿瘤的根本原因的系统。 瘘成熟过程中的血管重塑,或提供瘘功能障碍的综合诊断, 床边我们建议建立和临床验证超声诊断平台-称为点 弹性超声血管造影(eSA)具有前所未有的时间和空间分辨率, 识别血管壁边缘,并测量血管尺寸、弹性特性和心脏过程中的血管壁剪切率。 循环,以及在护理点的血管解剖结构的3D映射。在体外验证该工具后, (通过对简单和真实瘘管几何形状的体模研究)和体内(对 血液透析患者建立瘘管前后),我们计划将该软件作为开放平台工具发布 为研究人员。该软件工具将有助于术前计划和术后评估, 为血管成形术和外科翻修术的决策提供指导。鉴于超声波的普遍性和非侵入性 成像和广泛的开放获取,我们计划发布这个工具,这个建议可以从根本上加快 安全有效的超声诊断方法,用于瘘管优化。此外,鉴于普遍性 对于其他外周血管系统(颈动脉、四肢),该系统具有优化血管的潜力, 诊断,从而提高退伍军人患有外周和大脑功能的能力 动脉疾病通过在透析瘘管设置中验证该技术,该项目将奠定基础 为将来在血管医学中应用于扩大临床适应症的进一步临床研究提供参考。

项目成果

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William F Weitzel其他文献

William F Weitzel的其他文献

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{{ truncateString('William F Weitzel', 18)}}的其他基金

Point of Care Elastographic Sonoangiography (eSA)
护理点弹性超声血管造影 (eSA)
  • 批准号:
    9393446
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Point-of-Care Carotid Ultrasound and Cardiovascular Risk Assessment Device
护理点颈动脉超声和心血管风险评估装置
  • 批准号:
    8455104
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
Optimization of Dialysis Fistula Maturation via Vascular Ultrasound Elasticity an
通过血管超声弹性和优化透析瘘成熟
  • 批准号:
    8621267
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
Optimization of Dialysis Fistula Maturation via Vascular Ultrasound Elasticity an
通过血管超声弹性和优化透析瘘成熟
  • 批准号:
    8732651
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
Telehealth-Enabled Ultrasound-Bioimpedance Viscoelastographic Edema Monitoring
支持远程医疗的超声生物阻抗粘弹性成像水肿监测
  • 批准号:
    8795695
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Telehealth-Enabled Ultrasound-Bioimpedance Viscoelastographic Edema Monitoring
支持远程医疗的超声生物阻抗粘弹性成像水肿监测
  • 批准号:
    8330416
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Doppler Window for Low-Cost High-Performance Vascular Imaging
用于低成本高性能血管成像的多普勒窗口
  • 批准号:
    8253138
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Telehealth-Enabled Ultrasound-Bioimpedance Viscoelastographic Edema Monitoring
支持远程医疗的超声生物阻抗粘弹性成像水肿监测
  • 批准号:
    8460425
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Magnetic Drive Mechanism for VF Doppler Smart Sensor
VF多普勒智能传感器的磁力驱动机构
  • 批准号:
    8199261
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
VF Doppler Smart Sensor for Dialysis and Vascular Applications
适用于透析和血管应用的 VF 多普勒智能传感器
  • 批准号:
    7833128
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:

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