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Optimization of Dialysis Fistula Maturation via Vascular Ultrasound Elasticity an

通过血管超声弹性和优化透析瘘成熟

基本信息

批准号：
8732651
负责人：
William F Weitzel
金额：
$ 18.36万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-15 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8732651
关键词：
Algorithms Anatomy Angioplasty Architecture Arteries Arteriovenous fistula Blood Blood Vessels Blood flow Caliber Cardiac Catheters Clinical Clinical Research Clinical Trials Communication Complication Computer software Data Diagnostic Diagnostic Procedure Dialysis procedure Early Intervention Elasticity Failure Fistula Foundations Frequencies Future Gelatin Geometry Goals Grant Guidelines Health Services Accessibility Hemodialysis Image Imaging Device In Vitro Incidence Intervention Investigation Kidney Link Longevity Manufacturer Name Measurement Measures Mechanics Medical Medicine Methods Metric Multi-Institutional Clinical Trial Nature Operative Surgical Procedures Outcome Patients Physiological Pilot Projects Postoperative Period Prevalence Procedures Property Protocols documentation Public Domains Pulsatile Flow Radio Research Research Personnel Resolution Risk Sampling Second Look Surgery Software Tools Stimulus Stress Study Subject System Techniques Time Tissues Translating Ultrasonography Uncertainty United States National Institutes of Health Vascular remodeling Veins Velocimetries Venous abstracting base cost digital imaging elastography file format fluid flow hemodynamics image processing improved in vivo interest meetings particle public health relevance research study signal processing success tool

项目摘要

DESCRIPTION (provided by applicant): Optimization of Dialysis Fistula Maturation via Vascular Ultrasound Elasticity and Shear Rate Imaging R21: NIH PI: William Weitzel, MD Co-I: Albert Shih, PHD, Grant Kruger, Matthew Leavitt, Peter Henke Abstract Vascular access is crucial to the treatments necessary for hemodialysis patients. Due to their reliability, longevity, and lower complication rates, autogenous arteriovenous fistulas - surgically created connections between arteries and veins - have become increasingly prominent over other forms of vascular access. However, the uncertainty associated with fistula maturation has caused undue cost, risk, and stress to patients already undergoing significant medical procedures. Currently no system exists to directly and noninvasively measure the underlying causes of vascular remodeling during fistula maturation. We propose to build an ultrasound software toolbox - referred to as the vascular ultrasound elastography and shear rate (VUESR) imaging - that has unprecedented temporal and spatial resolution to identify vessel wall edges and measure vessel size, elastic properties, and blood-wall shear rate during the cardiac cycles. After validating thi tool both in vitro (through phantom studies on simple and realistic fistula geometries) and in vivo (a pilot study conducted on a small sample of hemodialysis patients pre- and post-fistula creation), we plan to release the software necessary for this technique available in the public domain as an open platform tool for researchers. This software tool will be useful for pre-operative planning and post-operative assessment to guide decisions for angioplasty and surgical revision. Given the ubiquity and noninvasive nature of ultrasound imaging and the broad open access with which we plan to release this tool, this proposal can radically accelerate safe and effective ultrasound diagnostic methods for fistula optimization.

描述（由申请人提供）：通过血管超声弹性和剪切率成像优化透析瘘成熟 R21：NIH PI：William Weitzel，医学博士 Co-I：Albert Shih，PHD，Grant Kruger，Matthew Leavitt，Peter Henke 摘要血管通路对于血液透析患者所需的治疗至关重要。由于其可靠性、使用寿命长，由于并发症发生率较低，自体动静脉瘘（通过手术在动脉和静脉之间建立连接）比其他形式的血管通路变得越来越重要。然而，与瘘管成熟相关的不确定性给已经接受重大医疗手术的患者带来了过度的成本、风险和压力。目前还没有系统可以直接且无创地测量瘘管成熟过程中血管重塑的根本原因。我们建议建立一个超声软件工具箱 - 称为血管超声弹性成像和剪切率（VUESR）成像 - 具有前所未有的时间和空间分辨率来识别血管壁边缘并测量心动周期期间的血管尺寸、弹性特性和血壁剪切率。在体外（通过对简单而真实的瘘管几何形状的模型研究）和体内验证该工具后（一项针对血液透析患者造瘘前后的小样本进行的试点研究），我们计划在公共领域发布该技术所需的软件，作为研究人员的开放平台工具。该软件工具可用于术前规划和术后评估，以指导血管成形术和手术修正的决策。鉴于超声成像的普遍性和非侵入性，以及我们计划发布该工具的广泛开放性，该提案可以从根本上加速用于瘘管优化的安全有效的超声诊断方法。