Point-of-Care Carotid Ultrasound and Cardiovascular Risk Assessment Device

护理点颈动脉超声和心血管风险评估装置

• 批准号: 8455104
• 负责人: William F Weitzel
• 金额: $ 19.88万
• 依托单位: ARBOR ULTRASOUND TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8455104
• 关键词: Algorithms; Anatomy; Architecture; Area; Blood Vessels; Blood flow; Caliber; Cardiovascular system; Caring; Carotid Arteries; Carotid Stenosis; Clinical; Communities; Consensus; Dependence; Detection; Development; Devices; Diagnostic; Digital Signal Processing; Distributed Systems; Elasticity; Electromagnetics; Electronics; Evaluation; Feedback; Generations; Grant; Guidelines; Hand; Image; Imagery; Magnetism; Marketing; Measurement; Measures; Medical; Medicine; Methods; Metric; Michigan; Motion; National Heart, Lung, and Blood Institute; Nurses; Patient Care; Performance; Phase; Physicians; Physiologic pulse; Point-of-Care Systems; Positioning Attribute; Price; Process; Production; Provider; Research; Research Personnel; Research Project Grants; Risk Assessment; Scanning; Side; Signal Transduction; Stenosis; Structure; System; Techniques; Technology; Testing; Thick; Three-Dimensional Image; Time; Transducers; Translational Research; Ultrasonography; United States National Institutes of Health; Universities; Width; Wireless Technology; analog; base; cardiovascular risk factor; clinical application; computerized data processing; cost; data acquisition; design; digital; effectiveness measure; engineering design; image processing; improved; innovation; intima media; meetings; miniaturize; novel; point of care; prototype; public health relevance; radiofrequency; sensor; success; tool

DESCRIPTION (provided by applicant): This proposal describes a novel, low-cost, high-performance compact carotid ultrasound imaging system to meet the clinical point-of-care needs for stenosis assessment based upon consensus practice criteria guidelines. At the same time, this system will meet the growing need for advanced cardiovascular (CV) risk assessment. This research integrates proven fundamental techniques with modern technology. The proposed device revisits standard ultrasound measurement techniques, but significantly improves on them. These improvements are achieved by using an innovative engineering design, accurate track and hold front-end, low-cost analog to digital converters, and an innovative electro-magnetic transducer drive system and distributed signal processing architecture to realize a high performance carotid imager at low manufacturing cost. Building upon the success of an NIH sponsored translational research project to make an ultrasound smart sensor (NHLBI grant 5RC1HL101881, William Weitzel, PI) and leveraging our proprietary radiofrequency (RF) ultrasound speckle tracking algorithms, we will develop application specific 3D measurement tools for the carotid artery. We leverage modern, miniaturized reconfigurable electronic components and high bandwidth wireless technology, to integrate low-level ultrasound signal generation, acquisition and pre-processing in the transducer-display module and then distribute (remotely perform) the higher-level signal processing, image construction and image processing. We build upon our current system hardware architecture to: 1) extend data acquisition into 3D meeting the point-of-care needs for carotid stenosis assessment, 2) develop server side system algorithms for improved operator independent measurements of stenosis using advanced signal processing and RF tracking, and 3) expand diagnostic capabilities for CV risk assessment by leveraging our technical advantages for accurately measuring carotid distensability using our innovative platform.

描述（由申请人提供）：该提案描述了一种新颖、低成本、高性能的紧凑型颈动脉超声成像系统，以满足基于共识实践标准指南的狭窄评估的临床护理需求。同时，该系统将满足对高级心血管（CV）风险评估日益增长的需求。这项研究将经过验证的基础技术与现代技术相结合。所提出的设备重新审视了标准超声测量技术，但对其进行了显着改进。这些改进是通过使用创新的工程设计、精确的跟踪和保持前端、低成本的模数转换器以及创新的电磁传感器驱动系统和分布式信号处理架构来实现的，以低制造成本实现高性能颈动脉成像仪。基于 NIH 资助的超声智能传感器转化研究项目的成功（NHLBI 拨款 5RC1HL101881，William Weitzel，PI）并利用我们专有的射频 (RF) 超声散斑跟踪算法，我们将为颈动脉开发特定于应用的 3D 测量工具。我们利用现代、小型化可重构电子元件和高带宽无线技术，将低级超声信号生成、采集和预处理集成到传感器显示模块中，然后分配（远程执行）更高级别的信号处理、图像构建和图像处理。我们以当前的系统硬件架构为基础：1) 将数据采集扩展到 3D，满足颈动脉狭窄评估的现场护理需求；2) 开发服务器端系统算法，使用先进的信号处理和 RF 跟踪改进独立于操作员的狭窄测量；3) 利用我们的创新平台精确测量颈动脉扩张性的技术优势，扩展 CV 风险评估的诊断能力。