Magnetic Drive Mechanism for VF Doppler Smart Sensor

描述（由申请人提供）：在透析血管通路故障（血栓形成）之前，血流量在一段未知的时间内从基线值降至零。虽然对通路故障之前的流量的自然历史和变化了解甚少，但已知在许多临床环境中，常规的每月通路流量监测不够频繁，无法充分预测和预防即将发生的血栓形成。出入监测的有效性取决于监测的频率和准确性。因此，正在开发VF多普勒自动智能传感器，用于透析期间的连续实时流量监测。我们假设，利用反馈技术的主动运动补偿/跟踪控制系统可用于生产商业上可行的基于床旁多普勒的血流监测设备，其适用于VF多普勒智能传感器（紧凑、低成本、连续）监测，用于透析和血管疾病的一般流量应用。我们的研究已经确定，引入具有相关反馈机制的主动换能器运动补偿将允许信号优化，从而提高先前未实现的血流测量精度。增加这种有源换能器驱动能力为实现实际临床可行性的可商业化设备引入了显著优势。它不仅将提高诊断流量测量的准确性，而且还将允许在透析设置之外的更广泛的血管流量应用中进行测量。因此，本建议将开发和评估一个实时传感器运动补偿系统的基础上的磁驱动机制的VF（体积流量）多普勒智能传感器与反馈控制。该提案建立在广泛的工作基础上，将降低NIH赞助技术成功商业化的风险。 公共卫生相关性：该建议将反馈控制系统和磁致动器集成到一个紧凑，低成本的多普勒自动化智能传感器，用于纵向操作员独立的血流监测。该设备将改善护理并降低透析患者和外周动脉疾病患者的成本。

DESCRIPTION (provided by applicant): Prior to dialysis vascular access failure (thrombosis), blood flow decreases from a baseline value to zero over some unknown time period. While the natural history and variation of flow prior to access failure is poorly understood, it is known that customary monthly access flow monitoring is not frequent enough in many clinical settings for adequate prediction and prevention of an impending thrombosis. The effectiveness of access surveillance depends on the frequency and accuracy with which monitoring can be performed. Therefore, the VF Doppler Automated Smart Sensor is being developed for continuous real-time flow monitoring during dialysis. We hypothesize that an active motion compensation/tracking control system utilizing feedback technology can be used to produce a commercially viable point-of-care Doppler based blood-flow monitoring device suitable for VF Doppler smart sensor (compact, low-cost, continuous) monitoring for dialysis and for general flow applications for vascular disease. Our research has determined that introducing active transducer motion compensation with the associated feedback mechanisms will allow for signal optimization improving blood flow measurement accuracy that has not been previously realized. Adding this active transducer drive capability introduces significant advantages for a commercializable device enabling practical clinical viability. Not only will it enhance the accuracy of the diagnostic flow measurement, but it also will allow measurements for broader vascular flow applications outside the dialysis setting. Therefore, this proposal will develop and evaluate a real-time transducer motion compensation system based on a magnetic drive mechanism for the VF (volume flow) Doppler smart sensor with feedback control. This proposal builds upon extensive work and will reduce the risk for successful commercial translation of this NIH sponsored technology. PUBLIC HEALTH RELEVANCE: This proposal will integrate a feedback control system and magnetic actuator into a compact, low-cost Doppler automated smart sensor for longitudinal operator-independent blood flow monitoring. This device will improve care and reduce cost for dialysis patients and patients with peripheral arterial disease.