Magnetic Drive Mechanism for VF Doppler Smart Sensor

描述(由申请人提供)：在透析血管通路失败(血栓形成)之前，血流量在一段未知的时间内从基线值下降到零。虽然对介入治疗失败前血流的自然历史和变化知之甚少，但众所周知，在许多临床环境中，常规的每月介入治疗血流监测不够频繁，无法充分预测和预防即将发生的血栓形成。访问监测的有效性取决于监测的频率和准确性。因此，VF多普勒自动智能传感器正在开发中，用于在透析过程中连续实时监测流量。我们假设，利用反馈技术的主动运动补偿/跟踪控制系统可以用于生产一种商业上可行的基于护理点多普勒的血流监测设备，适用于透析和血管疾病的普通血流应用的VF多普勒智能传感器(紧凑、低成本、连续)监测。我们的研究已经确定，引入具有相关反馈机制的主动换能器运动补偿将允许信号优化，从而提高以前尚未实现的血流测量精度。增加这种有源换能器驱动能力为可商业化的设备带来了显著的优势，使其具有实际的临床可行性。它不仅将提高诊断流量测量的准确性，而且还将允许在透析设置之外测量更广泛的血管流量应用。因此，该方案将为具有反馈控制的VF(体积流量)多普勒智能传感器开发和评估基于磁驱动机构的实时传感器运动补偿系统。这项建议建立在广泛工作的基础上，并将降低这项由NIH赞助的技术成功商业翻译的风险。 与公共健康相关：这项提案将把反馈控制系统和磁致动器集成到一个紧凑、低成本的多普勒自动智能传感器中，用于纵向独立于操作员的血流监测。该设备将改善透析患者和周围动脉疾病患者的护理并降低成本。

DESCRIPTION (provided by applicant): Prior to dialysis vascular access failure (thrombosis), blood flow decreases from a baseline value to zero over some unknown time period. While the natural history and variation of flow prior to access failure is poorly understood, it is known that customary monthly access flow monitoring is not frequent enough in many clinical settings for adequate prediction and prevention of an impending thrombosis. The effectiveness of access surveillance depends on the frequency and accuracy with which monitoring can be performed. Therefore, the VF Doppler Automated Smart Sensor is being developed for continuous real-time flow monitoring during dialysis. We hypothesize that an active motion compensation/tracking control system utilizing feedback technology can be used to produce a commercially viable point-of-care Doppler based blood-flow monitoring device suitable for VF Doppler smart sensor (compact, low-cost, continuous) monitoring for dialysis and for general flow applications for vascular disease. Our research has determined that introducing active transducer motion compensation with the associated feedback mechanisms will allow for signal optimization improving blood flow measurement accuracy that has not been previously realized. Adding this active transducer drive capability introduces significant advantages for a commercializable device enabling practical clinical viability. Not only will it enhance the accuracy of the diagnostic flow measurement, but it also will allow measurements for broader vascular flow applications outside the dialysis setting. Therefore, this proposal will develop and evaluate a real-time transducer motion compensation system based on a magnetic drive mechanism for the VF (volume flow) Doppler smart sensor with feedback control. This proposal builds upon extensive work and will reduce the risk for successful commercial translation of this NIH sponsored technology. PUBLIC HEALTH RELEVANCE: This proposal will integrate a feedback control system and magnetic actuator into a compact, low-cost Doppler automated smart sensor for longitudinal operator-independent blood flow monitoring. This device will improve care and reduce cost for dialysis patients and patients with peripheral arterial disease.