Magnetic Drive Mechanism for VF Doppler Smart Sensor

VF多普勒智能传感器的磁力驱动机构

• 批准号: 8199261
• 负责人: William F Weitzel
• 金额: $ 10.13万
• 依托单位: ARBOR ULTRASOUND TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199261
• 关键词: Affect; Algorithms; Award; Blood Vessels; Blood flow; Caring; Characteristics; Clinical; Computerized Medical Record; Development; Devices; Dialysis patients; Dialysis procedure; Effectiveness; Failure; Feedback; Financial compensation; Frequencies; Grant; Link; Magnetism; Marketing; Measurement; Michigan; Monitor; Motion; National Heart, Lung, and Blood Institute; Natural History; Patient Care; Patients; Performance; Peripheral arterial disease; Phase; Prevention; Private Sector; Process; Real-Time Systems; Research; Research Personnel; Resolution; Risk; Signal Transduction; System; Technology; Testing; Thrombosis; Time; Transducers; Translating; Translations; Ultrasonography; United States; United States National Institutes of Health; Universities; Variant; Vascular Diseases; Wireless Technology; Work; base; blood flow measurement; commercialization; cost; design; diagnostic accuracy; improved; innovation; monitoring device; point of care; sensor; success; usability

DESCRIPTION (provided by applicant): Prior to dialysis vascular access failure (thrombosis), blood flow decreases from a baseline value to zero over some unknown time period. While the natural history and variation of flow prior to access failure is poorly understood, it is known that customary monthly access flow monitoring is not frequent enough in many clinical settings for adequate prediction and prevention of an impending thrombosis. The effectiveness of access surveillance depends on the frequency and accuracy with which monitoring can be performed. Therefore, the VF Doppler Automated Smart Sensor is being developed for continuous real-time flow monitoring during dialysis. We hypothesize that an active motion compensation/tracking control system utilizing feedback technology can be used to produce a commercially viable point-of-care Doppler based blood-flow monitoring device suitable for VF Doppler smart sensor (compact, low-cost, continuous) monitoring for dialysis and for general flow applications for vascular disease. Our research has determined that introducing active transducer motion compensation with the associated feedback mechanisms will allow for signal optimization improving blood flow measurement accuracy that has not been previously realized. Adding this active transducer drive capability introduces significant advantages for a commercializable device enabling practical clinical viability. Not only will it enhance the accuracy of the diagnostic flow measurement, but it also will allow measurements for broader vascular flow applications outside the dialysis setting. Therefore, this proposal will develop and evaluate a real-time transducer motion compensation system based on a magnetic drive mechanism for the VF (volume flow) Doppler smart sensor with feedback control. This proposal builds upon extensive work and will reduce the risk for successful commercial translation of this NIH sponsored technology. PUBLIC HEALTH RELEVANCE: This proposal will integrate a feedback control system and magnetic actuator into a compact, low-cost Doppler automated smart sensor for longitudinal operator-independent blood flow monitoring. This device will improve care and reduce cost for dialysis patients and patients with peripheral arterial disease.

描述（由申请人提供）：在透析血管通道失败（血栓形成）之前，在某些未知时间段内，血流从基线值降低到零。虽然对进入失败前的自然病史和流量的变化知之甚少，但众所周知，在许多临床环境中，习惯的每月通道流量监测不够频繁，无法进行充分的预测和预防即将来临的血栓形成。访问监视的有效性取决于可以进行监视的频率和准确性。因此，正在开发VF多普勒自动化智能传感器，用于在透析过程中连续实时流量监测。我们假设使用反馈技术的主动运动补偿/跟踪控制系统可用于生产商业上可行的基于护理多普勒的血液流量监测设备，适用于VF多普勒智能传感器（紧凑，低成本，连续）监测糖尿病，以用于糖尿病，并用于用于血管疾病的一般流动应用。我们的研究确定，引入使用相关反馈机制的主动换能器运动补偿将允许信号优化提高以前尚未实现的血流测量精度。添加此主动传感器驱动能力为可商业化的设备带来了显着优势，从而实现了实用的临床生存能力。它不仅可以提高诊断流量测量的准确性，而且还可以允许测量透析设置以外的更广泛的血管流动应用。因此，该提案将基于通过反馈控制的VF（体积流）多普勒智能传感器的磁性驱动机制开发和评估实时传感器运动补偿系统。该提案以广泛的工作为基础，并将降低该NIH赞助技术成功商业翻译的风险。 公共卫生相关性：该提案将将反馈控制系统和磁执行器整合到一个紧凑的低成本多普勒自动化智能传感器中，以用于纵向操作员的血液流量监测。该设备将改善护理并降低透析患者和周围动脉疾病的患者的成本。