Magnetic Drive Mechanism for VF Doppler Smart Sensor

VF多普勒智能传感器的磁力驱动机构

• 批准号: 8199261
• 负责人: William F Weitzel
• 金额: $ 10.13万
• 依托单位: ARBOR ULTRASOUND TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199261
• 关键词: Affect; Algorithms; Award; Blood Vessels; Blood flow; Caring; Characteristics; Clinical; Computerized Medical Record; Development; Devices; Dialysis patients; Dialysis procedure; Effectiveness; Failure; Feedback; Financial compensation; Frequencies; Grant; Link; Magnetism; Marketing; Measurement; Michigan; Monitor; Motion; National Heart, Lung, and Blood Institute; Natural History; Patient Care; Patients; Performance; Peripheral arterial disease; Phase; Prevention; Private Sector; Process; Real-Time Systems; Research; Research Personnel; Resolution; Risk; Signal Transduction; System; Technology; Testing; Thrombosis; Time; Transducers; Translating; Translations; Ultrasonography; United States; United States National Institutes of Health; Universities; Variant; Vascular Diseases; Wireless Technology; Work; base; blood flow measurement; commercialization; cost; design; diagnostic accuracy; improved; innovation; monitoring device; point of care; sensor; success; usability

DESCRIPTION (provided by applicant): Prior to dialysis vascular access failure (thrombosis), blood flow decreases from a baseline value to zero over some unknown time period. While the natural history and variation of flow prior to access failure is poorly understood, it is known that customary monthly access flow monitoring is not frequent enough in many clinical settings for adequate prediction and prevention of an impending thrombosis. The effectiveness of access surveillance depends on the frequency and accuracy with which monitoring can be performed. Therefore, the VF Doppler Automated Smart Sensor is being developed for continuous real-time flow monitoring during dialysis. We hypothesize that an active motion compensation/tracking control system utilizing feedback technology can be used to produce a commercially viable point-of-care Doppler based blood-flow monitoring device suitable for VF Doppler smart sensor (compact, low-cost, continuous) monitoring for dialysis and for general flow applications for vascular disease. Our research has determined that introducing active transducer motion compensation with the associated feedback mechanisms will allow for signal optimization improving blood flow measurement accuracy that has not been previously realized. Adding this active transducer drive capability introduces significant advantages for a commercializable device enabling practical clinical viability. Not only will it enhance the accuracy of the diagnostic flow measurement, but it also will allow measurements for broader vascular flow applications outside the dialysis setting. Therefore, this proposal will develop and evaluate a real-time transducer motion compensation system based on a magnetic drive mechanism for the VF (volume flow) Doppler smart sensor with feedback control. This proposal builds upon extensive work and will reduce the risk for successful commercial translation of this NIH sponsored technology. PUBLIC HEALTH RELEVANCE: This proposal will integrate a feedback control system and magnetic actuator into a compact, low-cost Doppler automated smart sensor for longitudinal operator-independent blood flow monitoring. This device will improve care and reduce cost for dialysis patients and patients with peripheral arterial disease.

描述（由申请人提供）：在透析血管通路失败（血栓形成）之前，血流量在某个未知的时间段内从基线值减少到零。虽然对通路故障之前血流的自然史和变化知之甚少，但众所周知，在许多临床环境中，常规的每月通路血流监测不够频繁，不足以充分预测和预防即将发生的血栓形成。访问监控的有效性取决于监控的频率和准确性。因此，正在开发 VF 多普勒自动智能传感器，用于透析过程中的连续实时流量监测。我们假设利用反馈技术的主动运动补偿/跟踪控制系统可用于生产商业上可行的基于多普勒的护理点血流监测设备，适用于透析的 VF 多普勒智能传感器（紧凑、低成本、连续）监测和血管疾病的一般流量应用。我们的研究已经确定，引入主动传感器运动补偿和相关反馈机制将允许信号优化，提高血流测量精度，这是以前从未实现的。添加这种有源传感器驱动能力为商业化设备带来了显着的优势，从而实现了实际的临床可行性。它不仅可以提高诊断流量测量的准确性，而且还可以在透析环境之外进行更广泛的血管流量应用的测量。因此，本提案将开发和评估基于磁驱动机构的实时传感器运动补偿系统，用于带反馈控制的 VF（体积流量）多普勒智能传感器。该提案建立在广泛的工作基础上，并将降低这项 NIH 资助的技术成功商业转化的风险。 公共健康相关性：该提案将反馈控制系统和磁力执行器集成到紧凑、低成本的多普勒自动化智能传感器中，用于独立于操作员的纵向血流监测。该设备将改善透析患者和患有外周动脉疾病的患者的护理并降低费用。