VF Doppler Smart Sensor for Dialysis and Vascular Applications

适用于透析和血管应用的 VF 多普勒智能传感器

基本信息

批准号：
7833128
负责人：
William F Weitzel
金额：
$ 50万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7833128
关键词：
Address Adoption Algorithms Area Blood Vessels California Characteristics Clinical Clinical Research Collaborations Communities Computer software Decision Making Development Devices Diagnostic Dialysis patients Dialysis procedure Economics Effectiveness Electronics End stage renal failure Engineering Failure Frequencies Funding Goals Grant Health Care Costs Health Care Sector Hemodialysis K-Series Research Career Programs Laboratories Laboratory Study Lead Measurement Measures Mentors Methods Michigan Monitor Natural History Occupations Patient Monitoring Patients Performance Prevention Private Sector Randomized Randomized Clinical Trials Research Institute Research Personnel Risk Savings Sensitivity and Specificity Stimulus System Technology Testing Thrombosis Time Transducers Translational Research Translations Ultrasonography United States United States National Institutes of Health Universities Validation Variant base clinical application cost design improved instrument monitoring device novel programs prospective public health relevance sensor technology development user-friendly

项目摘要

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area 15: Translational Science and specific Challenge Topic 15-RR-101: Applied Translational Technology Development. It is evident that prior to dialysis access failure (thrombosis), access flow decreases for every dialysis patient from a baseline value to zero over some time period. However, the natural history and variation of access failure is still poorly understood, as evidenced by mixed results when access flow monitoring is implemented clinically. What is known is that customary monthly access flow monitoring is not frequent enough in many clinical settings. Since the effectiveness of access surveillance depends on the frequency with which monitoring can be performed, an easy-to-use and accurate method of measuring access flow is needed to understand flow variation and to determine how to optimally monitor patients with differing characteristics. The new instrument being developed and tested in this project is based on mature Doppler technology mitigating development risk, yet will employ a novel measurement method, technologically advanced electronics and software to make a user-friendly, low-cost Doppler- based monitoring device tailored for dialysis access monitoring. This smart sensor will allow cost-effective, accurate flow monitoring during each dialysis treatment for every patient, which is essential to optimize combined sensitivity and specificity for this clinical application. The results of this proposal will 1) improve dialysis decision-making leading to a paradigm shift to optimize access monitoring and 2) provide a platform Doppler device for other vascular applications. Further, this project will actually reduce dialysis vascular access cost. Realistic estimates indicate $300 million in annual savings in the US alone, while stimulating jobs in the technical healthcare sector. PUBLIC HEALTH RELEVANCE: It is important to fund technologies that will make US workers more competitive in the global marketplace by reducing overall healthcare costs. This project achieves the scientific and economic objectives of the ARRA. This project will result in a low-cost compact Doppler based smart sensor for dialysis vascular access management. This device and technology will reduce dialysis healthcare cost and are easily generalizable to other vascular applications, offering a high-performance alternative to existing Doppler devices. The project supports rapid translation into the private sector and job creation achieving scientific and economic stimulus objectives of the ARRA.

描述（由申请人提供）：此申请应解决广泛的挑战领域15：转化科学和特定挑战主题15-RR-101：应用转化技术开发。显然，在透析进入失败（血栓形成）之前，每个透析患者在一段时间内的透析患者从基线值降低到零。但是，当临床上实施访问流量监测时，结果混合的结果证明了访问失败的自然病史和差异仍然很少。众所周知，在许多临床环境中，习惯的每月访问流量监控不够频繁。由于访问监视的有效性取决于可以进行监视的频率，因此需要一种易于使用和准确的测量访问流量来了解流动变化，并确定如何最佳地监测具有不同特征的患者。该项目中正在开发和测试的新仪器基于成熟的多普勒技术来缓解开发风险，但将采用一种新颖的测量方法，技术先进的电子设备和软件来使用户友好，低成本的基于多普勒的监测设备量身定制，该设备量身定制了用于透析访问监测的方法。该智能传感器将在每位患者的每种透析治疗过程中允许在每种透析治疗期间进行成本效益，准确的流量监测，这对于优化此临床应用的组合敏感性和特异性至关重要。该提案的结果将1）改善透析决策，从而导致范式转移以优化访问监控，2）为其他血管应用提供平台多普勒设备。此外，该项目实际上将降低透析血管通道成本。现实的估计表明，仅在美国，每年节省了3亿美元，同时刺激了技术医疗保健领域的工作。公共卫生相关性：为了通过降低整体医疗保健成本，资助将使美国工人在全球市场上更具竞争力的技术资助非常重要。该项目实现了ARRA的科学和经济目标。该项目将导致基于低成本的紧凑型多普勒智能传感器，用于透析血管访问管理。该设备和技术将降低透析医疗保健成本，并易于推广到其他血管应用，并提供现有多普勒设备的高性能替代品。该项目支持快速转化为私营部门，并创造就业，以实现ARRA的科学和经济刺激目标。