Agonist-Antagonist Myoneural Interface for Functional Limb Restoration after Transtibial Amputation

激动剂-拮抗剂肌神经接口用于小腿截肢后肢体功能恢复

• 批准号: 9893886
• 负责人: HUGH M HERR
• 金额: $ 58.68万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-14 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9893886
• 关键词: Acute; Affect; Agonist; American; Amputation; Anatomy; Ankle; Architecture; Behavior; Biomechanics; Biomimetics; Bionics; Body part; Clinical; Collection; Communication; Data; Devices; Electrodes; Electromyography; Emotional; Esthesia; Evaluation; Exhibits; Feedback; Freedom; Gait; Goals; Health; Human; Intervention; Intervention Studies; Joint Prosthesis; Joints; Kinetics; Leg; Limb structure; Lower Extremity; Mechanics; Mechanoreceptors; Methodology; Methods; Modeling; Motion; Motor; Movement; Muscle; Natural regeneration; Nervous system structure; Neuraxis; Operative Surgical Procedures; Participant; Performance; Persons; Phantom Limb; Physiological; Physiology; Positioning Attribute; Productivity; Proprioception; Prosthesis; Psychometrics; Quality of life; Reflex action; Rehabilitation therapy; Research Design; Research Personnel; Resistance; Sensory; Series; Signal Transduction; Speed; Stretching; Subtalar joint structure; System; Testing; Time; Tissues; Torque; Ultrasonography; Work; active lifestyle; ankle joint; base; case control; clinically translatable; cohort; communication device; cost; electric impedance; first-in-human; force feedback; functional electrical stimulation; graphical user interface; group intervention; healthy lifestyle; improved; insight; joint mobilization; kinematics; limb amputation; meetings; motor control; myoelectric control; novel; preservation; prospective; prosthesis control; recruit; regenerative; relating to nervous system; response; restoration; visual feedback

Project Summary/Abstract Humans have the ability to precisely sense the position, speed, and torque of their body parts. This sense is known as proprioception. In the many attempts to create human-mechatronic interactions there is still no robust, repeatable methodology to reflect proprioceptive information from a synthetic device onto the nervous system. The study presents a novel bi-directional neural communication paradigm – called the Agonist- antagonist Myoneural Interface (AMI) – for functional limb restoration after transtibial amputation. The AMI is a neural communication architecture comprised of two muscles – an agonist and an antagonist – surgically connected in series within the amputated residuum so that contraction of one muscle stretches the other. The AMI preserves important dynamic muscle relationships that exist within native anatomy, thereby allowing proprioceptive signals from mechanoreceptors within both muscles to be communicated to the central nervous system. It is hypothesized that surgically-constructed AMIs, created within the residuum during limb amputation, can afford an improved independent control of joint position and impedance in a multi-degree-of- freedom prosthesis while also reflecting proprioceptive sensation from each prosthetic joint onto the central nervous system. Following a prospective, case-control intervention model, we recruit healthy, active participants with transtibial amputations with and without the novel AMI surgical intervention. Each subject in the intervention group has an amputated residuum comprising two AMIs, enabling clinically translatable studies of myoelectric control of a prosthesis with actuated ankle and subtalar joints, and experimental demonstrations of closed-loop prosthetic joint torque control. Specific Aim 1 investigates if AMIs can improve control over voluntary prosthesis movement. Specific Aim 2 determines if AMIs can preserve involuntary (reflexive) gait behaviors during irregular terrain ambulation. Specific Aim 3 explores if an AMI construct can provide closed- loop joint torque control with somatotopically-matched force feedback. The research design includes the collection of electromyography, ultrasound, biomechanical (kinematic and kinetic), and psychometric data. Closed-loop joint torque control is provided through functional electrical stimulation. The extent of functional limb restoration enabled by the AMIs will be assessed using metric-based performance evaluations. Through insights on the capabilities of surgically-created bi-directional neural interfaces, the study provides a framework for integrating bionic systems with human physiology to improve the health, productivity, independence, and quality of life of persons with amputations.

项目摘要/摘要 人类具有精确感知身体部位的位置，速度和扭矩的能力。这个感觉是 被称为本体感受。在许多创建人工学互动的尝试中，仍然没有 强大的可重复方法，以反映合成装置的本体感受信息到神经 系统。该研究提出了一种新型的双向神经通信范式 - 称为激动剂 - 拮抗剂肌肉界面（AMI） - 用于截肢截肢后的功能性肢体恢复。 AMI是一个 神经交流结构完成了两种肌肉 - 一个激动剂和对手 - 手术 在截肢的残留物中以串联相连，因此一种肌肉的收缩会伸展另一种肌肉。这 AMI保留了本地解剖结构中存在的重要动态肌肉关系，从而允许 来自两种肌肉中的机制感受器的本体感受信号都将传达给中枢神经 系统。假设在肢体期间在残留物中产生的外科手术结构的AMI 截肢，可以改善对联合位置和阻抗的独立控制 自由假体，同时还反映了从每个假肢到中心的本体感受的感觉 神经系统。按照前瞻性，病例对照干预模型，我们招募健康，活跃 有或没有新型AMI手术干预的跨位截肢的参与者。每个主题in 干预组的截肢残留物包括两个AMI，可实现临床可翻译的研究 用激活的踝关节和下关节对假体的肌电控制以及实验示范 闭环假肢扭矩控制。特定目标1调查AMI是否可以改善对的控制 自愿假体运动。特定目标2确定AMIS是否可以保持非自愿（反射性）步态 不规则地形行走期间的行为。特定的目标3探索AMI结构是否可以提供闭合 - 循环连接扭矩控制，并具有体形匹配的力反馈。研究设计包括 收集肌电图，超声，生物力学（运动学和动力学）以及心理测量数据。 通过功能电气模拟提供了闭环接头扭矩控制。功能的程度 由AMIS启用的肢体修复将使用基于公制的性能评估进行评估。通过 对手术创建的双向神经界面功能的见解，研究提供了一个框架 将仿生系统与人类生理学相结合，以提高健康，生产力，独立性和 截肢者的生活质量。