Agonist-Antagonist Myoneural Interface for Functional Limb Restoration after Transtibial Amputation
激动剂-拮抗剂肌神经接口用于小腿截肢后肢体功能恢复
基本信息
- 批准号:10560547
- 负责人:
- 金额:$ 52.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-03-14 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:AcuteAffectAgonistAmericanAmputationAnatomyAnkleArchitectureBehaviorBiomechanicsBiomimeticsBionicsBody partCentral Nervous SystemClinicalCollectionCommunicationDataDevicesElectrodesElectromyographyEmotionalEsthesiaEvaluationExhibitsFeedbackFreedomGaitGoalsHealthHumanInterventionIntervention StudiesJoint ProsthesisJointsKineticsLegLimb structureLower ExtremityMechanicsMechanoreceptorsMethodologyMethodsModelingMotionMotorMovementMuscleNatural regenerationNervous SystemOperative Surgical ProceduresParticipantPerformancePersonsPhantom LimbPhysiologicalPhysiologyPositioning AttributeProductivityProprioceptionProsthesisPsychometricsQuality of lifeRehabilitation therapyResearch DesignResearch PersonnelResistanceSensorySeriesSignal TransductionSpecific qualifier valueSpeedStretchingSubtalar joint structureSystemTestingTimeTissuesTorqueWorkactive lifestyleankle jointankle prosthesisantagonistcase controlclinical translationcohortcommunication devicecostelectric impedancefirst-in-humanforce feedbackfunctional electrical stimulationgraphical user interfacegroup interventionhealthy lifestyleimprovedinsightjoint mobilizationkinematicslimb amputationlimb lossmeetingsmotor controlmyoelectric controlneuralnovelpreservationprospectiveprosthesis controlrecruitregenerativeresponserestorationultrasoundverbalvisual feedback
项目摘要
Project Summary/Abstract
Humans have the ability to precisely sense the position, speed, and torque of their body parts. This sense is
known as proprioception. In the many attempts to create human-mechatronic interactions there is still no
robust, repeatable methodology to reflect proprioceptive information from a synthetic device onto the nervous
system. The study presents a novel bi-directional neural communication paradigm – called the Agonist-
antagonist Myoneural Interface (AMI) – for functional limb restoration after transtibial amputation. The AMI is a
neural communication architecture comprised of two muscles – an agonist and an antagonist – surgically
connected in series within the amputated residuum so that contraction of one muscle stretches the other. The
AMI preserves important dynamic muscle relationships that exist within native anatomy, thereby allowing
proprioceptive signals from mechanoreceptors within both muscles to be communicated to the central nervous
system. It is hypothesized that surgically-constructed AMIs, created within the residuum during limb
amputation, can afford an improved independent control of joint position and impedance in a multi-degree-of-
freedom prosthesis while also reflecting proprioceptive sensation from each prosthetic joint onto the central
nervous system. Following a prospective, case-control intervention model, we recruit healthy, active
participants with transtibial amputations with and without the novel AMI surgical intervention. Each subject in
the intervention group has an amputated residuum comprising two AMIs, enabling clinically translatable studies
of myoelectric control of a prosthesis with actuated ankle and subtalar joints, and experimental demonstrations
of closed-loop prosthetic joint torque control. Specific Aim 1 investigates if AMIs can improve control over
voluntary prosthesis movement. Specific Aim 2 determines if AMIs can preserve involuntary (reflexive) gait
behaviors during irregular terrain ambulation. Specific Aim 3 explores if an AMI construct can provide closed-
loop joint torque control with somatotopically-matched force feedback. The research design includes the
collection of electromyography, ultrasound, biomechanical (kinematic and kinetic), and psychometric data.
Closed-loop joint torque control is provided through functional electrical stimulation. The extent of functional
limb restoration enabled by the AMIs will be assessed using metric-based performance evaluations. Through
insights on the capabilities of surgically-created bi-directional neural interfaces, the study provides a framework
for integrating bionic systems with human physiology to improve the health, productivity, independence, and
quality of life of persons with amputations.
项目摘要/摘要
人类有能力精确地感觉到他们身体部位的位置、速度和扭矩。这种感觉是
被称为本体感觉。在创造人机交互的许多尝试中,仍然没有
稳健、可重复的方法,将本体感觉信息从合成设备反映到神经上
系统。这项研究提出了一种新的双向神经交流范式--激动者--
拮抗剂肌神经接口(AMI)-用于经胫骨截肢后的功能肢体重建。急性心肌梗死是一种
由两块肌肉组成的神经通信结构--一个是激动者,一个是拮抗者--外科手术
在截肢残端内串联,使一块肌肉的收缩伸展另一块肌肉。这个
AMI保留了存在于本地解剖学中的重要的动态肌肉关系,从而允许
来自两个肌肉中的机械感受器的本体感觉信号传递到中枢神经
系统。据推测,手术构建的急性心肌梗死是在肢体残端内形成的
截肢,可以提供一个改进的独立控制关节的位置和阻抗在多个程度-
自由假体,同时也将本体感觉从每个假体关节反射到中央
神经系统。遵循前瞻性病例对照干预模式,我们招募健康、积极的
接受和不接受新型急性心肌梗死手术干预的经胫骨截肢患者。中的每个主题
干预组有截肢的残留物,包括两个急性心肌梗死,使临床可翻译的研究成为可能
踝关节和距下关节致动假体的肌电控制和实验演示
对假体关节扭矩进行了闭环控制。特定目标1调查急性心肌梗死是否可以改善对
自愿性假体运动。特定目标2确定急性心肌梗死是否可以保持不自主(反射性)步态
不规则地形移动时的行为。具体目标3探索AMI构造是否可以提供闭合的
体位匹配力反馈的环路关节力矩控制。研究设计包括
肌电、超声、生物力学(运动学和运动学)和心理测量数据的收集。
通过功能电刺激提供闭环式关节扭矩控制。功能的范围
将使用基于指标的性能评估来评估由AMIS实现的肢体恢复。穿过
对手术创建的双向神经接口能力的洞察,这项研究提供了一个框架
将仿生系统与人类生理学相结合,以提高健康、生产力、独立性和
截肢者的生活质量。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Restoration of bilateral motor coordination from preserved agonist-antagonist coupling in amputation musculature.
- DOI:10.1186/s12984-021-00829-z
- 发表时间:2021-02-17
- 期刊:
- 影响因子:5.1
- 作者:Shu T;Huang SS;Shallal C;Herr HM
- 通讯作者:Herr HM
Agonist-antagonist muscle strain in the residual limb preserves motor control and perception after amputation.
- DOI:10.1038/s43856-022-00162-z
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Song, Hyungeun;Israel, Erica A;Gutierrez-Arango, Samantha;Teng, Ashley C;Srinivasan, Shriya S;Freed, Lisa E;Herr, Hugh M
- 通讯作者:Herr, Hugh M
Acquisition of Surface EMG Using Flexible and Low-Profile Electrodes for Lower Extremity Neuroprosthetic Control.
- DOI:10.1109/tmrb.2021.3098952
- 发表时间:2021-08
- 期刊:
- 影响因子:0
- 作者:Yeon SH;Shu T;Song H;Hsieh TH;Qiao J;Rogers EA;Gutierrez-Arango S;Israel E;Freed LE;Herr HM
- 通讯作者:Herr HM
The Agonist-antagonist Myoneural Interface.
- DOI:10.1097/bto.0000000000000552
- 发表时间:2021-12
- 期刊:
- 影响因子:0
- 作者:Herr H;Carty MJ
- 通讯作者:Carty MJ
Neural interfacing architecture enables enhanced motor control and residual limb functionality postamputation.
- DOI:10.1073/pnas.2019555118
- 发表时间:2021-03-02
- 期刊:
- 影响因子:11.1
- 作者:Srinivasan SS;Gutierrez-Arango S;Teng AC;Israel E;Song H;Bailey ZK;Carty MJ;Freed LE;Herr HM
- 通讯作者:Herr HM
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HUGH M HERR其他文献
HUGH M HERR的其他文献
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{{ truncateString('HUGH M HERR', 18)}}的其他基金
Agonist-Antagonist Myoneural Interface for Functional Limb Restoration after Transtibial Amputation
激动剂-拮抗剂肌神经接口用于小腿截肢后肢体功能恢复
- 批准号:
9893886 - 财政年份:2019
- 资助金额:
$ 52.39万 - 项目类别:
Agonist-Antagonist Myoneural Interface for Functional Limb Restoration after Transtibial Amputation
激动剂-拮抗剂肌神经接口用于小腿截肢后肢体功能恢复
- 批准号:
10355484 - 财政年份:2019
- 资助金额:
$ 52.39万 - 项目类别:
Computational Design, Fabrication, and Evaluation of Optimized Patient-Specific Transtibial Prosthetic Sockets
优化的患者专用跨胫假肢接受腔的计算设计、制造和评估
- 批准号:
9753235 - 财政年份:2017
- 资助金额:
$ 52.39万 - 项目类别:
Computational Design, Fabrication, and Evaluation of Optimized Patient-Specific Transtibial Prosthetic Sockets
优化的患者专用跨胫假肢接受腔的计算设计、制造和评估
- 批准号:
9363821 - 财政年份:2017
- 资助金额:
$ 52.39万 - 项目类别:
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