Interdisciplinary Training in Virology and Gene Therapy

病毒学和基因治疗跨学科培训

• 批准号: 9519811
• 负责人: TING-TING WU
• 金额: $ 25.83万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9519811
• 关键词: Training; gene therapy; virology

DESCRIPTION (provided by applicant): Developments in virology have led to the development of several classes of therapeutics, including treatments or prevention of microbial infection and gene therapy. Gene therapy holds the promise of therapeutic options for a variety of diseases. A key issue in gene therapy is the development of gene delivery vehicles that evade immune or inflammatory response, are non-toxic, and target the gene effectively. To fulfill the national need for these types of therapeutic options, the UCLA Virology and Gene Therapy Training Program aims to provide a unique and outstanding environment for predoctoral and postdoctoral trainees pursuing research careers in fields related to gene therapy. This program will establish a solid training in fundamental virology and its applications in gene therapy. The research interests of our faculty encompass viral entry, viral gene expression regulation, replication of viral genome, cell biology during viral infection, viral particle assembly, viral carcinogenesis and viral immunology, as well as designing novel vectors and tracking viral vectors in vivo. With strong basic research programs on retroviruses, adenoviruses, SV40, hepatitis C, poliovirus, influenza virus and herpesviruses, our faculty has been and will be continuously developing viral vectors from these viruses and monitoring gene expression in vivo using non-invasive imaging technologies in combination stem cell biology. The trainees will be exposed to clinical and diagnostic issues during their training to underscore the therapeutic applications of their research projects, and be encouraged to form translational collaborations with basic and clinical mentors. This bridge in training environment will enhance the translation from basic science to clinical application in gene and cellular therapy. The training program constitutes 1) original research work with one or more of our faculty; 2) formal course work which provides comprehensive background on virology and gene therapy; and 3) regular research conferences and seminars, presented by invited guest speakers, faculty members and trainees; 4) training in best practices in research, responsible conduct and career development. The training committee will select trainees via a competitive process. Appointments are renewable with satisfactory progress (up to 2 years predoctoral, 1 year postdoctoral). The training program is fully integrated with the reorganized PhD programs in biosciences at UCLA. The progress of the trainees and the program are reviewed periodically. At UCLA, this rigorous training program with emphasis on vertical integration of basic sciences and therapeutic applications produces the scientists required for long-term development of virology and gene therapy.

描述（由申请人提供）：病毒学的发展导致了几类治疗方法的发展，包括微生物感染的治疗或预防以及基因治疗。基因治疗为各种疾病的治疗选择带来了希望。基因治疗中的一个关键问题是开发逃避免疫或炎症反应、无毒且有效靶向基因的基因递送载体。为了满足国家对这些类型的治疗选择的需求，加州大学洛杉矶分校病毒学和基因治疗培训计划旨在为在基因治疗相关领域从事研究工作的博士前和博士后学员提供独特而出色的环境。该计划将建立一个坚实的基础病毒学及其在基因治疗中的应用培训。我们的教师的研究兴趣包括病毒进入，病毒基因表达调控，病毒基因组的复制，病毒感染过程中的细胞生物学，病毒颗粒组装，病毒致癌和病毒免疫学，以及设计新型载体和体内追踪病毒载体。凭借对逆转录病毒、腺病毒、SV 40、丙型肝炎、脊髓灰质炎病毒、流感病毒和疱疹病毒的强大基础研究计划，我们的教师已经并将继续开发这些病毒的病毒载体，并使用非侵入性成像技术监测体内基因表达结合干细胞生物学。学员将在培训期间接触临床和诊断问题，以强调其研究项目的治疗应用，并鼓励与基础和临床导师形成翻译合作。这座培训环境的桥梁将促进基因和细胞治疗从基础科学到临床应用的转化。该培训计划包括1）与我们的一个或多个教师的原创研究工作; 2）正式的课程工作，提供病毒学和基因治疗的全面背景;和3）定期研究会议和研讨会，由特邀演讲嘉宾，教师和学员提出; 4）在研究，负责任的行为和职业发展的最佳实践培训。培训委员会将通过竞争程序挑选受训人员。奖学金是可再生的，并取得令人满意的进展（最多2年博士前，1年博士后）。该培训计划与加州大学洛杉矶分校生物科学的重组博士课程完全整合。本集团定期检讨受训人员及计划的进度。在加州大学洛杉矶分校，这个严格的培训计划，重点是基础科学和治疗应用的垂直整合，产生病毒学和基因治疗的长期发展所需的科学家。

项目成果

High-resolution genetic profile of viral genomes: why it matters.

• DOI: 10.1016/j.coviro.2015.08.005
• 发表时间: 2015-10
• 期刊: Current opinion in virology
• 影响因子: 5.9
• 作者: Hangfei Qi;N. Wu;Yushen Du;Ting-Ting Wu-Ting;R. Sun

Delivery of Genome Editing Reagents to Hematopoietic Stem/Progenitor Cells.

• DOI: 10.1002/9780470151808.sc05b04s36
• 发表时间: 2016-02-03
• 期刊: Current protocols in stem cell biology
• 作者: Hoban, Megan D;Romero, Zulema;Kohn, Donald B
• 通讯作者: Kohn, Donald B

Mechanistic insights into reprogramming to induced pluripotency.

• DOI: 10.1002/jcp.22450
• 发表时间: 2011-04
• 期刊: JOURNAL OF CELLULAR PHYSIOLOGY
• 影响因子: 5.6
• 作者: Ho, Ritchie;Chronis, Constantinos;Plath, Kathrin
• 通讯作者: Plath, Kathrin

Hematopoietic Stem Cell Gene Therapy: Progress and Lessons Learned.

• DOI: 10.1016/j.stem.2017.10.010
• 发表时间: 2017-11-02
• 期刊: Cell stem cell
• 影响因子: 23.9
• 作者: Morgan RA;Gray D;Lomova A;Kohn DB
• 通讯作者: Kohn DB

Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.

• DOI: 10.1038/s41541-020-00251-x
• 发表时间: 2020-11-05
• 期刊: NPJ vaccines
• 影响因子: 9.2
• 作者: Brar G;Farhat NA;Sukhina A;Lam AK;Kim YH;Hsu T;Tong L;Lin WW;Ware CF;Blackman MA;Sun R;Wu TT
• 通讯作者: Wu TT