3/3; Promoting resilience in children:Protocol Development for a Birth Cohort Study to Access Factors Impacting Neurodevelopment
3/3;
基本信息
- 批准号:9900395
- 负责人:
- 金额:$ 26.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-30 至 2022-03-31
- 项目状态:已结题
- 来源:
- 关键词:10 year oldAccountingAddressAdolescentAffectAgeAgreementAlcohol or Other Drugs useAreaBiologicalBirthBrainBrain MappingChildChild DevelopmentChild HealthChildhoodCognitiveCohort StudiesCollaborationsCollectionCommunitiesComplexConsultationsDataData CollectionDatabasesDevelopmentEnsureEnvironmentEnvironmental ExposureEnvironmental HealthEnvironmental Risk FactorEthical IssuesEthicsEvaluationExposure toFamilyFoundationsFrightFutureGeneticGoalsGuidelinesHealthHealth PromotionHome environmentHumanInfantInterventionInvestigationKnowledgeLawsLegalLifeLinkLongitudinal StudiesMagnetic Resonance ImagingMeasurementMeasuresMethodologyModelingMothersNear-Infrared SpectroscopyNeuraxisNeurocognitiveOpioidOutcomeParticipantPersonal SatisfactionPhasePhase II Clinical TrialsPilot ProjectsPoliciesPostpartum WomenPovertyPregnancyPregnant WomenProtocols documentationResearchResourcesRiskRisk FactorsSafetySamplingSedation procedureSocial InteractionSpecimenStandardizationStructureSubstance Use DisorderSurveysTarget PopulationsTechniquesTestingTimeVulnerable PopulationsWomanWorkaddictionadverse childhood eventsbrain behaviorcognitive abilitycognitive developmentcognitive performancecognitive testingcohortcritical perioddesignearly childhoodearly life exposureexperiencefetalflexibilitymultidisciplinarymultimodalitymyelinationneurodevelopmentneuroimagingopioid exposureopioid useopioid use in pregnancypeer supportphase 2 studypostnatal periodprenatalprenatal exposureprotocol developmentpublic health relevancerecruitresilienceretention ratesocialsocial stigma
项目摘要
PROMOTING RESILIENCE IN CHILDREN: PROTOCOL DEVELOPMENT FOR A BIRTH COHORT STUDY
TO ASSESS FACTORS IMPACTING NEURODEVELOPMENT
ABSTRACT
The first ten years of life are accompanied by rapid changes to the developing brain and cognitive abilities. A
multitude of complex interacting factors including genetics, early-life exposure to substances, family and social
interactions, and home and community environments can affect the trajectories of brain and cognitive
development. Adequate investigations of these effects and interactions have been limited by several factors,
including challenges associated with the recruitment and retention of pregnant women with prenatal substance
use; the legal, ethical and regulatory issues associated with studies of substance-using pregnant women and
children; and the difficulties of performing neuroimaging in infants and young children without sedation. These
three linked and synergistic projects aim to address these challenges by developing effective research
protocols to lay a foundation for a successful future large-scale, national HEALthy Brain and Cognitive
Development (HBCD) birth cohort study, which will follow the developmental trajectories for a decade. Project
1 will develop protocols for recruitment and retention of a diverse sample of pregnant and postpartum women
with oversampling of mothers with prenatal opioid use. Project 2 will identify ethical, legal and regulatory
challenges for investigations in this vulnerable population, and subsequently define effective solutions to
enable recruitment and study of these participants. Project 3 will develop and evaluate protocols for acquiring
high-quality, quantitative neuroimaging measures with magnetic resonance imaging and functional near
infrared spectroscopy, as well as assess effective strategies for measuring cognitive performance in young
children, including those exposed to opioids. These linked projects are essential to address the major
challenges with the planned HBCD study and will leverage a highly collaborative, multidisciplinary team;
leading-edge neuroimaging techniques; and outstanding institutional resources.
促进儿童的复原力:出生队列研究方案的制定
评估影响神经发育的因素
摘要
生命的前十年伴随着大脑和认知能力的快速变化。一
许多复杂的相互作用的因素,包括遗传学,早期生活暴露于物质,家庭和社会
互动,家庭和社区环境可以影响大脑和认知的轨迹
发展对这些影响和相互作用的充分研究受到几个因素的限制,
包括与招募和留住使用产前药物的孕妇有关的挑战
使用;与使用药物的孕妇研究相关的法律的、道德的和监管问题
儿童;以及在没有镇静剂的情况下对婴儿和幼儿进行神经成像的困难。这些
三个相互联系和协同作用的项目旨在通过开展有效的研究来应对这些挑战
协议,为未来成功的大规模,国家健康的大脑和认知
六溴环十二烷出生队列研究,该研究将跟踪十年的发展轨迹。项目
1.将制定方案,招募和保留各种孕妇和产后妇女样本
对产前使用阿片类药物的母亲进行了过度抽样。项目2将确定道德、法律的和监管的
在这一弱势群体中开展调查的挑战,并随后确定有效的解决办法,
能够招募和研究这些参与者。项目3将制定和评估获取
通过磁共振成像和功能近距离成像进行高质量、定量神经成像测量
红外光谱,以及评估有效的策略,测量认知性能的年轻人
儿童,包括接触阿片类药物的儿童。这些相互联系的项目对于解决主要的
计划的六溴环十二烷研究面临的挑战,并将利用高度协作的多学科团队;
领先的神经成像技术和杰出的机构资源。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANDREW L ALEXANDER其他文献
ANDREW L ALEXANDER的其他文献
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{{ truncateString('ANDREW L ALEXANDER', 18)}}的其他基金
Toward Healthy Aging in Adults with Autism: A Longitudinal Clinical and Multimodal Brain Imaging Study
成年自闭症患者健康老龄化:纵向临床和多模态脑成像研究
- 批准号:
10698180 - 财政年份:2022
- 资助金额:
$ 26.16万 - 项目类别:
Auditory function, cognition, language and brain structure in Down Syndrome
唐氏综合症的听觉功能、认知、语言和大脑结构
- 批准号:
10391010 - 财政年份:2022
- 资助金额:
$ 26.16万 - 项目类别:
Toward Healthy Aging in Adults with Autism: A Longitudinal Clinical and Multimodal Brain Imaging Study
成年自闭症患者健康老龄化:纵向临床和多模态脑成像研究
- 批准号:
10523387 - 财政年份:2022
- 资助金额:
$ 26.16万 - 项目类别:
Motion Robust Relaxometry for Infant Neuroimaging
用于婴儿神经影像的运动鲁棒松弛测量法
- 批准号:
10583970 - 财政年份:2022
- 资助金额:
$ 26.16万 - 项目类别:
Motion Robust Relaxometry for Infant Neuroimaging
用于婴儿神经影像的运动鲁棒松弛测量法
- 批准号:
10708164 - 财政年份:2022
- 资助金额:
$ 26.16万 - 项目类别:
High Performance Gradient System for Advanced Neuroimaging Research
用于高级神经影像研究的高性能梯度系统
- 批准号:
10176634 - 财政年份:2021
- 资助金额:
$ 26.16万 - 项目类别:
3/3; Promoting resilience in children:Protocol Development for a Birth Cohort Study to Access Factors Impacting Neurodevelopment
3/3;
- 批准号:
10013563 - 财政年份:2019
- 资助金额:
$ 26.16万 - 项目类别:
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