Brain Imaging Core

韦斯曼中心的研究人员通过调查 动物模型和个体的大脑结构和功能，表现为或处于这些情况的风险中。这个 Waisman脑成像核心(BIC)提供这些研究和服务所需的所有工具和服务 包括磁共振成像(MRI)、人体正电子发射断层扫描(PET)、高分辨率 动物成像的分辨率PET，成像过程中的辅助生理记录，以及广泛的软件 图像分析的工具和培训。该设施在提供系统级别的神经科学方面起着关键作用。 它位于神经发育、行为和分子分析水平之间的界面上。具体的 脑成像核心的目标是：目标1开发MRI、PET、fNIRS硬件、方法和 用于正常发育、非典型发育和非典型发育神经成像研究的软件技术 人类和动物模型中的神经退行性变。这一目标的目标包括所有可用的 IDD调查人员可使用的神经成像方式和资源。我们还提供访问高度 逼真的核磁共振模拟器，使参与者能够适应程序并排练行为 扫描中使用的协议。目标2为神经成像方案提供专业知识和指导 威斯康星大学麦迪逊分校研究IDD人群和动物的开发和实验设计 模特们。这一目标的目的是确保IDD调查人员能够获得 在他们计划、启动和开展研究项目时使用神经成像方法。BIC的工作人员配备了高度 熟练的成像科学家，在MRI脉冲序列设计，PET神经受体成像， 放射性药物开发、啮齿动物和非人类灵长类动物成像和数据分析。目标3：提供 为调查人员及其工作人员提供培训和技术支持，使他们能够使用 比克。这一目标的目标包括举办课程和培训讲习班、定期更新技术 在BIC每月会议和参与PIS的实验室会议上，与工作人员和 PI的学生，开发专门的扫描序列和数据采集协议 在影像数据统计分析方面的应用、咨询和支持。总体活动和 BIC的职能将以丰富威斯康星州神经科学界传播为目标 为IDDS的研究提供想法、实施计划和培训神经影像科学家。

Waisman Center investigators study intellectual and developmental disabilities (IDD) through investigating the brain structure and function in both animal models and individuals exhibiting or at risk for these conditions. The Waisman Brain Imaging Core (BIC) provides all of the tools and services required for these investigations and includes facilities for magnetic resonance imaging (MRI), human positron emission tomography (PET), high- resolution PET for animal imaging, ancillary physiological recordings during imaging, and extensive software tools and training for image analysis. This facility occupies a key role in providing systems level neuroscience that lies at the interface between the neurodevelopment, behavioral and molecular levels of analysis. The specific aims for for the Brain Imaging Core are: Aim 1 to develop MRI, PET, fNIRS hardware, methodologies and software technologies for neuroimaging studies of normal development, atypical development, and neurodegeneration in both humans and animal models. The objectives of this aim encompass all of the available neuroimaging modalities and resources available for IDD investigators. We also provide access to a highly realistic MRI simulator to enable participants to acclimate to the procedures and rehearse the behavioral protocols that are used in scanning. Aim 2 to provide expertise and guidance for neuroimaging protocol development and experimental design to UW-Madison investigators for studying IDD populations and animal models. The objectives of this aim are to ensure IDD investigators have access to technical expertise in neuroimaging methods as they plan, initiate and conduct their research projects. The BIC is staffed with highly skilled imaging scientists with expertise in MRI pulse sequence design, PET neuroreceptor imaging, radiopharmaceutical development, rodent and nonhuman primate imaging and data analytics. Aim 3 to provide training and technical support for investigators and their staffs in the use of all of the imaging modalities in the BIC. The objectives of this aim include the conduct of courses and training workshops, regular technical updates at BIC monthly meetings and lab meetings of the participating PIs, specialized consultation with the staff and students of PIs, development of specialized scanning sequences and data acquisition protocols for novel applications and consultation and support in statistical analysis of imaging data. The overall activities and function of the BIC will be directed by the goal of enriching the UW neuroscience community to disseminate ideas, implement plans and train neuroimaging scientists for research in IDDs.