High Performance Gradient System for Advanced Neuroimaging Research

摘要 这笔赠款将支持我们购买一台超高性能的GE Magnus磁头梯度系统 韦斯曼脑成像实验室(WBIL)推出10年的专用3-TESLA磁共振系统(GE MR750) 威斯康星大学麦迪逊分校(UW-Madison)。马格努斯纯磁头梯度的设计 系统最大限度地减少对周围神经的刺激，这是唯一能够实现极高梯度幅度和 回转速度(每轴200Mt/m和500T/m/S)。Magnus升级将在以下方面提供重大推动 神经成像表现包括减少回声平面失真和模糊，常规高质量 连接组脑成像协议具有显著更高的空间分辨率和极端扩散加权 成像能力。核磁共振系统的升级还包括对系统射频电子设备的改进 通过低噪声数字接收机，减小发射线圈体积，降低射频功率沉积，以及 一个新的32通道接收器磁头线圈。Magnus扫描仪将是一项独特的、高端的脑成像研究 为18名以上的调查人员和25个当前项目提供资源，其中大部分是NIH- 有资金支持。将受到积极影响的主要研究领域包括衰老和痴呆症的研究， 情感神经科学，神经发育，智力和发育障碍，神经疾病， 和基础神经科学。威斯康星大学麦迪逊分校的Magnus扫描仪也将是一种尖端的神经成像 新项目的研究资源，这些项目将开发和应用下一代技术来研究大脑 结构、微结构和功能具有更精细的尺度和比目前任何其他可能的更高的灵敏度 人体核磁共振扫描仪平台。

ABSTRACT This grant will support the purchase of an ultrahigh-performance GE MAGNUS head gradient system to our 10+ year old research-dedicated 3-Tesla MRI system (GE MR750) in the Waisman Brain Imaging Lab (WBIL) at the University of Wisconsin – Madison (UW-Madison). The design of the MAGNUS head-only gradient system minimizes peripheral nerve stimulation, which uniquely enables extremely high gradient amplitudes and slew rates (200 mT/m and 500 T/m/s on each axis). The MAGNUS upgrade will provide major boosts in neuroimaging performance including reduced echo planar distortion and blurring, routine high-quality connectome brain imaging protocols with significantly higher spatial resolution, and extreme diffusion-weighted imaging capabilities. The MRI system upgrade also includes improvements to the system RF electronics through 64 low-noise digital receivers, reduced volume transmit coil with decreased RF power deposition, and a new 32-channel receiver head coil. The MAGNUS scanner will be a unique, high-end brain imaging research resource at UW-Madison for more than 18 investigators and 25 current projects, most of which are NIH- funded. Major areas of research that will be positively impacted include studies of aging and dementia, affective neuroscience, neurodevelopment and intellectual and developmental disorders, neurological disease, and basic neuroscience. The UW-Madison MAGNUS scanner will also be a cutting-edge neuroimaging research resource for new projects that will develop and apply next generation techniques to investigate brain structure, microstructure and function at finer scales and higher sensitivity than currently possible on any other human MRI scanner platform.