High Performance Gradient System for Advanced Neuroimaging Research

用于高级神经影像研究的高性能梯度系统

• 批准号: 10176634
• 负责人: ANDREW L ALEXANDER
• 金额: $ 200万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176634
• 关键词: 10 year old; Aging; Area; Brain; Brain imaging; Dementia; Deposition; Diffusion Magnetic Resonance Imaging; Electronics; Funding; Grant; Head; Human; Magnetic Resonance Imaging; Neurosciences; Noise; Performance; Peripheral Nerve Stimulation; Protocols documentation; Research; Research Personnel; Resolution; Resources; Structure; System; Techniques; United States National Institutes of Health; Universities; Wisconsin; advanced system; affective neuroscience; connectome; design; developmental disease; digital; imaging capabilities; nervous system disorder; neurodevelopment; neuroimaging; next generation

ABSTRACT This grant will support the purchase of an ultrahigh-performance GE MAGNUS head gradient system to our 10+ year old research-dedicated 3-Tesla MRI system (GE MR750) in the Waisman Brain Imaging Lab (WBIL) at the University of Wisconsin – Madison (UW-Madison). The design of the MAGNUS head-only gradient system minimizes peripheral nerve stimulation, which uniquely enables extremely high gradient amplitudes and slew rates (200 mT/m and 500 T/m/s on each axis). The MAGNUS upgrade will provide major boosts in neuroimaging performance including reduced echo planar distortion and blurring, routine high-quality connectome brain imaging protocols with significantly higher spatial resolution, and extreme diffusion-weighted imaging capabilities. The MRI system upgrade also includes improvements to the system RF electronics through 64 low-noise digital receivers, reduced volume transmit coil with decreased RF power deposition, and a new 32-channel receiver head coil. The MAGNUS scanner will be a unique, high-end brain imaging research resource at UW-Madison for more than 18 investigators and 25 current projects, most of which are NIH- funded. Major areas of research that will be positively impacted include studies of aging and dementia, affective neuroscience, neurodevelopment and intellectual and developmental disorders, neurological disease, and basic neuroscience. The UW-Madison MAGNUS scanner will also be a cutting-edge neuroimaging research resource for new projects that will develop and apply next generation techniques to investigate brain structure, microstructure and function at finer scales and higher sensitivity than currently possible on any other human MRI scanner platform.

摘要 这笔赠款将支持购买一个超高性能的GE MAGNUS头部梯度系统， Waisman脑成像实验室（WBIL）中使用10年以上的研究专用3 T MRI系统（GE MR 750） 在威斯康星州-麦迪逊大学（UW-麦迪逊）。MAGNUS头部梯度的设计 系统最大限度地减少了外周神经刺激，这独特地实现了极高的梯度振幅， 转换速率（每个轴上为200 mT/m和500 T/m/s）。MAGNUS的升级将大大提升 神经成像性能，包括减少回波平面失真和模糊，常规高质量 连接体脑成像协议具有显著更高的空间分辨率和极高的扩散加权 成像能力。MRI系统升级还包括对系统RF电子器件的改进 通过64个低噪声数字接收器，减少发射线圈的体积，减少射频功率沉积，以及 一个新的32通道接收器头部线圈MAGNUS扫描仪将是一种独特的、高端的脑成像研究 资源在威斯康星大学麦迪逊分校超过18名研究人员和25个当前的项目，其中大部分是美国国立卫生研究院- 资金。将受到积极影响的主要研究领域包括衰老和痴呆症研究， 情感神经科学，神经发育和智力与发育障碍，神经疾病， 和基础神经科学。威斯康星大学麦迪逊分校的MAGNUS扫描仪也将是一个尖端的神经成像 新项目的研究资源，将开发和应用下一代技术来研究大脑 结构、微观结构和功能，比目前任何其他技术都更精细，灵敏度更高。 人体MRI扫描仪平台。