Brain Imaging Core

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Waisman Center investigators study intellectual and developmental disabilities (IDD) through investigating the brain structure and function in both animal models and individuals exhibiting or at risk for these conditions. The Waisman Brain Imaging Core (BIC) provides all of the tools and services required for these investigations and includes facilities for magnetic resonance imaging (MRI), human positron emission tomography (PET), high- resolution PET for animal imaging, ancillary physiological recordings during imaging, and extensive software tools and training for image analysis. This facility occupies a key role in providing systems level neuroscience that lies at the interface between the neurodevelopment, behavioral and molecular levels of analysis. The specific aims for for the Brain Imaging Core are: Aim 1 to develop MRI, PET, fNIRS hardware, methodologies and software technologies for neuroimaging studies of normal development, atypical development, and neurodegeneration in both humans and animal models. The objectives of this aim encompass all of the available neuroimaging modalities and resources available for IDD investigators. We also provide access to a highly realistic MRI simulator to enable participants to acclimate to the procedures and rehearse the behavioral protocols that are used in scanning. Aim 2 to provide expertise and guidance for neuroimaging protocol development and experimental design to UW-Madison investigators for studying IDD populations and animal models. The objectives of this aim are to ensure IDD investigators have access to technical expertise in neuroimaging methods as they plan, initiate and conduct their research projects. The BIC is staffed with highly skilled imaging scientists with expertise in MRI pulse sequence design, PET neuroreceptor imaging, radiopharmaceutical development, rodent and nonhuman primate imaging and data analytics. Aim 3 to provide training and technical support for investigators and their staffs in the use of all of the imaging modalities in the BIC. The objectives of this aim include the conduct of courses and training workshops, regular technical updates at BIC monthly meetings and lab meetings of the participating PIs, specialized consultation with the staff and students of PIs, development of specialized scanning sequences and data acquisition protocols for novel applications and consultation and support in statistical analysis of imaging data. The overall activities and function of the BIC will be directed by the goal of enriching the UW neuroscience community to disseminate ideas, implement plans and train neuroimaging scientists for research in IDDs.