Brain Imaging Core

脑成像核心

• 批准号: 10678932
• 负责人: ANDREW L ALEXANDER
• 金额: $ 18.86万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678932
• 关键词: Acclimatization; Animal Model; Behavioral; Blood flow; Brain; Brain imaging; Cerebrum; Communities; Computer Systems; Computer software; Consultations; Data; Data Analytics; Data Storage and Retrieval; Development; Diagnosis; Diffusion Magnetic Resonance Imaging; Educational workshop; Energy Metabolism; Ensure; Environment; Exhibits; Experimental Designs; Functional Magnetic Resonance Imaging; Goals; High Performance Computing; Human; Image; Image Analysis; Individual; Infrastructure; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Investigation; MRI Scans; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Methodology; Methods; Modality; Molecular; Morphologic artifacts; Motion; Nerve Degeneration; Neurosciences; Neurotransmitters; Participant; Performance; Perfusion; Physics; Physiologic pulse; Physiological; Physiology; Population; Positron-Emission Tomography; Procedures; Protocols documentation; Quality Control; Radiopharmaceuticals; Research; Research Personnel; Research Project Grants; Resolution; Resources; Rest; Risk; Rodent; Scanning; Scientist; Sensory Receptors; Services; Software Tools; Spectrum Analysis; Statistical Data Interpretation; Structure; Students; System; Talents; Technical Expertise; Technology; Training; Update; animal imaging; anxiety reduction; base; behavioral phenotyping; computer science; data acquisition; design; functional near infrared spectroscopy; human model; image processing; imaging modality; imaging scientist; insight; instrument; meetings; neural; neural correlate; neural patterning; neurochemistry; neurodevelopment; neuroimaging; neuropathology; nonhuman primate; novel; novel marker; protocol development; radiotracer; skills; statistics; tool; white matter

Waisman Center investigators study intellectual and developmental disabilities (IDD) through investigating the brain structure and function in both animal models and individuals exhibiting or at risk for these conditions. The Waisman Brain Imaging Core (BIC) provides all of the tools and services required for these investigations and includes facilities for magnetic resonance imaging (MRI), human positron emission tomography (PET), high- resolution PET for animal imaging, ancillary physiological recordings during imaging, and extensive software tools and training for image analysis. This facility occupies a key role in providing systems level neuroscience that lies at the interface between the neurodevelopment, behavioral and molecular levels of analysis. The specific aims for for the Brain Imaging Core are: Aim 1 to develop MRI, PET, fNIRS hardware, methodologies and software technologies for neuroimaging studies of normal development, atypical development, and neurodegeneration in both humans and animal models. The objectives of this aim encompass all of the available neuroimaging modalities and resources available for IDD investigators. We also provide access to a highly realistic MRI simulator to enable participants to acclimate to the procedures and rehearse the behavioral protocols that are used in scanning. Aim 2 to provide expertise and guidance for neuroimaging protocol development and experimental design to UW-Madison investigators for studying IDD populations and animal models. The objectives of this aim are to ensure IDD investigators have access to technical expertise in neuroimaging methods as they plan, initiate and conduct their research projects. The BIC is staffed with highly skilled imaging scientists with expertise in MRI pulse sequence design, PET neuroreceptor imaging, radiopharmaceutical development, rodent and nonhuman primate imaging and data analytics. Aim 3 to provide training and technical support for investigators and their staffs in the use of all of the imaging modalities in the BIC. The objectives of this aim include the conduct of courses and training workshops, regular technical updates at BIC monthly meetings and lab meetings of the participating PIs, specialized consultation with the staff and students of PIs, development of specialized scanning sequences and data acquisition protocols for novel applications and consultation and support in statistical analysis of imaging data. The overall activities and function of the BIC will be directed by the goal of enriching the UW neuroscience community to disseminate ideas, implement plans and train neuroimaging scientists for research in IDDs.

魏斯曼中心的研究人员通过调查智力和发育障碍（IDD）， 在动物模型和表现出这些病症或处于这些病症风险中的个体中的脑结构和功能。的 Waisman Brain Imaging Core（BIC）提供这些研究所需的所有工具和服务， 包括磁共振成像（MRI），人体正电子发射断层扫描（PET），高， 用于动物成像的高分辨率PET，成像期间的辅助生理记录，以及广泛的软件 图像分析工具和培训。该设施在提供系统级神经科学方面发挥着关键作用 它位于神经发育、行为和分子水平分析之间的界面。具体 脑成像核心的目标是：目标1开发MRI，PET，fNIRS硬件，方法和 用于正常发育、非典型发育的神经成像研究的软件技术， 在人类和动物模型中的神经变性。这一目标的目标包括所有现有的 神经成像模式和资源可供IDD研究者。我们还提供访问高度 逼真的MRI模拟器，使参与者能够适应程序并排练行为 用于扫描的协议。目的2为神经影像学检查提供专业知识和指导 开发和实验设计，以研究IDD人群和动物 模型这一目标的目的是确保缺碘症调查人员能够获得以下方面的技术专门知识： 他们计划，启动和进行他们的研究项目的神经成像方法。BIC的工作人员配备了 在MRI脉冲序列设计、PET神经受体成像、 放射性药物开发、啮齿动物和非人灵长类动物成像和数据分析。目标3提供 为研究者及其工作人员提供使用所有成像模式的培训和技术支持， BIC。这一目标的目标包括举办课程和培训讲习班，定期进行技术更新， 在BIC月度会议和参与PI的实验室会议上，与工作人员进行专业咨询， PI的学生，开发专门的扫描序列和数据采集协议， 影像数据统计分析的应用、咨询和支持。总体活动和 BIC的功能将以丰富华盛顿大学神经科学界的目标为指导， 我们的目标是为IDDs的研究提供思路、实施计划和培训神经影像科学家。