3/3; Promoting resilience in children:Protocol Development for a Birth Cohort Study to Access Factors Impacting Neurodevelopment

3/3；

• 批准号: 10013563
• 负责人: ANDREW L ALEXANDER
• 金额: $ 26.16万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10013563
• 关键词: 10 year old; Accounting; Address; Adolescent; Affect; Age; Agreement; Alcohol or Other Drugs use; Area; Biological; Birth; Brain; Brain Mapping; Child; Child Development; Child Health; Childhood; Cognitive; Cohort Studies; Collaborations; Collection; Communities; Complex; Consultations; Data; Data Collection; Databases; Development; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Ethical Issues; Ethics; Evaluation; Exposure to; Family; Foundations; Fright; Future; Genetic; Goals; Guidelines; Health; Health Promotion; Home environment; Human; Infant; Intervention; Investigation; Knowledge; Laws; Legal; Life; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Methodology; Modeling; Mothers; Near-Infrared Spectroscopy; Neuraxis; Neurocognitive; Opioid; Outcome; Participant; Personal Satisfaction; Phase; Phase II Clinical Trials; Pilot Projects; Policies; Postpartum Women; Poverty; Pregnancy; Pregnant Women; Protocols documentation; Research; Resources; Risk; Risk Factors; Safety; Sampling; Sedation procedure; Social Interaction; Specimen; Standardization; Structure; Substance Use Disorder; Surveys; Target Populations; Techniques; Testing; Time; Vulnerable Populations; Woman; Work; addiction; adverse childhood events; brain behavior; cognitive ability; cognitive development; cognitive performance; cognitive testing; cohort; critical period; design; early childhood; early life exposure; experience; fetal; flexibility; multidisciplinary; multimodality; myelination; neurodevelopment; neuroimaging; opioid exposure; opioid use; opioid use in pregnancy; peer support; phase 2 study; postnatal period; prenatal; prenatal exposure; protocol development; public health relevance; recruit; resilience; retention rate; social; social stigma

PROMOTING RESILIENCE IN CHILDREN: PROTOCOL DEVELOPMENT FOR A BIRTH COHORT STUDY TO ASSESS FACTORS IMPACTING NEURODEVELOPMENT ABSTRACT The first ten years of life are accompanied by rapid changes to the developing brain and cognitive abilities. A multitude of complex interacting factors including genetics, early-life exposure to substances, family and social interactions, and home and community environments can affect the trajectories of brain and cognitive development. Adequate investigations of these effects and interactions have been limited by several factors, including challenges associated with the recruitment and retention of pregnant women with prenatal substance use; the legal, ethical and regulatory issues associated with studies of substance-using pregnant women and children; and the difficulties of performing neuroimaging in infants and young children without sedation. These three linked and synergistic projects aim to address these challenges by developing effective research protocols to lay a foundation for a successful future large-scale, national HEALthy Brain and Cognitive Development (HBCD) birth cohort study, which will follow the developmental trajectories for a decade. Project 1 will develop protocols for recruitment and retention of a diverse sample of pregnant and postpartum women with oversampling of mothers with prenatal opioid use. Project 2 will identify ethical, legal and regulatory challenges for investigations in this vulnerable population, and subsequently define effective solutions to enable recruitment and study of these participants. Project 3 will develop and evaluate protocols for acquiring high-quality, quantitative neuroimaging measures with magnetic resonance imaging and functional near infrared spectroscopy, as well as assess effective strategies for measuring cognitive performance in young children, including those exposed to opioids. These linked projects are essential to address the major challenges with the planned HBCD study and will leverage a highly collaborative, multidisciplinary team; leading-edge neuroimaging techniques; and outstanding institutional resources.

促进儿童复原力：出生队列研究的方案制定