DIFFUSION TENSOR IMAGING OF AMYGDALO-FRONTAL PATHWAYS

在这个项目中，我们将评估大脑中白质连接的微观结构特性 与人类青少年和非人类灵长类动物的情绪调节异常有关。 弥散张量成像(DTI)将用于表征路径的白质微结构(主要 通过钩状束)位于杏仁核和前额叶皮质之间，构成初级大脑 情绪调节的回路。这个项目有四个目标。第一个目标是与DTI相关的 猕猴钩束对杏仁核反应性和慢性应激的测量 曝光率(项目1)。我们预测，杏仁核高反应性和压力暴露的猴子将 显示这个白质区域中最不正常的连接。第二和第三个目标是 在具有良好特征的人类青少年群体中，对钩状束进行相关的DTI测量。(项目2 3)皮质醇的儿科测量(项目2)和遗传与经验因素 内在化障碍(项目3)。我们预测钩状束的微结构将出现异常。 青少年(A)儿童皮质醇水平高，(B)有内在性障碍的风险。第四次 目的：探讨扣带回DTI检查与fMRI情绪调节检查之间的关系。 青少年(项目4)。我们预测钩状束的DTI特性将与 情绪调节任务中的fMRI信号

In this project we will evaluate whether the microstructural properties of white matter connections in the brain are related to abnormalities in emotion regulation in both human adolescents and nonhuman primates. Diffusion tensor imaging (DTI) will be used to characterize white matter microstructure of pathways (primarily through the uncinate fasciculus) between the amygdala and prefrontal cortex, which form the primary brain circuitry for emotion regulation. There are four aims of this project. The first aim is to related DTI measurements in the uncinate fasciculus of monkeys to measures of amygdala reactivity and chronic stress exposure (with Project 1). We predict that monkeys with high amygdala reactivity and stress exposure will demonstrate the most abnormal connections in this white matter region. The second and third aims are to relate DTI measures in the uncinate fasciculus of well-characterized human adolescent groups. (Projects 2 and 3) to pediatric measures of cortisol (Project 2) and genetic versus experiential factors related to internalizing disorders (Project 3). We predict that the uncinate fasciculus microstructure will be abnormal in adolescents with (a) high chronic levels of pediatric cortisol, and (b) risk of internalizing disorders. The fourth aim is to relate DTI measures in the uncinate fasciculus with fMRI measures of emotion regulation in adolescents (Project 4). We predict that the DTI properties of the uncinate fasciculus will be related to the fMRI signals in response to emotion regulation tasks