ShEEP Request for Electrospinner Machine

ShEEP 请求静电纺丝机

• 批准号: 9905925
• 负责人: Daniel Kacy Cullen
• 金额: --
• 依托单位: PHILADELPHIA VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9905925
• 关键词: Air; Area; Attention; Biocompatible Materials; Biological; Caliber; Catalogs; Cell Adhesion; Chemicals; Corrosives; Coupled; Development; Devices; Dimensions; Drug Delivery Systems; Electrospinning; Electrostatics; Environment; Equipment; Fiber; Funding; Goals; Health; Hybrids; Medical center; Musculoskeletal; Musculoskeletal Diseases; Nanosphere; Nanostructures; Nanotechnology; Needles; Nerve Degeneration; Nervous System Trauma; Nervous system structure; Pattern; Philadelphia; Polymers; Polytetrafluoroethylene; Process; Production; Proteins; Regenerative Medicine; Research; Research Activity; Research Personnel; Research Project Grants; Resolution; Sample Size; Sampling; Sheep; Speed; Surface; Syringes; Techniques; Technology; Testing; Time; Tissue Engineering; Tube; Veterans; Width; Work; Wound Healing; base; design; improved; melting; member; nanocomposite; nanofiber; nanomaterials; nanoscale; next generation; novel; regenerative therapy; restoration; retinal rods; scaffold; voltage

ABSTRACT The purpose of this large equipment proposal is to provide funding for a Co-Axial Electrospinning setup along with all necessary accessories. The Co-Axial Electrospinning setup would add a new dimension to the biomaterial fabrication capacity at Corporal Michael J. Crescenz Veterans Affairs Medical Center (CMC-VAMC) in Philadelphia and specifically advance research at the Center for Neurotrauma, Neurodegeneration & Restoration (CNNR) and Translational Musculoskeletal Research Center (TMRC). Electrospinning is a widely used technique for the electrostatic production of nanofibers, during which electric power is used to make polymer fibers with diameters ranging from 2 nm to several nanometres from polymer solutions or melts. This process is a major focus of attention because of its versatility and ability to continuously produce fibers on a scale of nanometres, which is difficult to achieve using other standard technologies. The application of nanomaterials in biomedicine is currently at the forefront of development. Compared with conventional materials, the surface area of nanostructured material is inherently much larger, allowing for the adhesion of cells, proteins and/or active ingredients. There are a range of cutting-edge applications of Nanomaterials in Biomedicine, including, but not limited to, Tissue Engineering, Drug Delivery, Scaffolds, and Wound Healing. Acquisition of a new Co-Axial Electropsinning setup and accessories for the CMC-VAMC will have an immediate and profound positive impact on research activities. Coupled to our existing core equipment, this new acquisition will fully equip the CMC- VAMC to develop advanced nanotechnology based biomaterial scaffolds. This will be a great benefit to the entirety of the CMC-VAMC research enterprise, and particularly useful for members of the CNNR and TMRC. Acquisition of the proposed equipment will help the investigators overcome limitations in their current environment due to the lack of a co-axial electrospinning setup. The proposed equipment will allow current VA- funded Veteran-centric research projects to move forward at a much faster pace. The new device will also allow investigators to develop advanced biomaterial based products with unprecedented nano-scale resolution. Together, this will improve research focused on Veterans health, thus furthering the VAMC’s long-term research goals.

摘要 这个大型设备提案的目的是为沿着的同轴静电纺丝装置提供资金 所有必要的配件。同轴静电纺丝装置将为生物材料增加一个新的维度 迈克尔·J·克雷森兹下士退伍军人事务医疗中心（CMC-VAMC）的制造能力， 费城，特别是神经创伤，神经变性和恢复中心的高级研究 （CNNR）和翻译肌肉骨骼研究中心（TMRC）。静电纺丝是一种广泛应用的技术 用于静电生产纳米纤维，在此期间，电力用于制造聚合物纤维， 直径范围从2纳米到几纳米的聚合物溶液或熔体。这个过程是一个重大的 由于其多功能性和连续生产纳米级纤维的能力， 这是使用其它标准技术难以实现的。纳米材料在生物医学中的应用 目前处于发展的前沿。与传统材料相比， 纳米结构材料固有地大得多，允许细胞、蛋白质和/或活性物质的粘附。 成分.纳米材料在生物医学中有一系列前沿应用，包括但不限于 仅限于组织工程、药物递送、支架和伤口愈合。购买新的同轴电缆 CMC-VAMC的Electropsinning设置和配件将产生直接而深远的积极影响 关于研究活动。加上我们现有的核心设备，这次新收购将完全装备CMC- VAMC开发基于先进纳米技术的生物材料支架。这将是一个很大的好处， CMC-VAMC研究企业的整体，特别是对CNNR和TMRC的成员有用。 购置拟议的设备将有助于调查人员克服目前工作的局限性， 由于缺乏同轴静电纺丝装置，建议的设备将允许当前VA- 资助以退伍军人为中心的研究项目，以更快的速度向前迈进。新设备还将允许 研究人员开发先进的生物材料为基础的产品与前所未有的纳米级分辨率。 总之，这将改善对退伍军人健康的研究，从而促进VAMC的长期研究 目标.