Academic-Industry Partnership for the Translation of a 4D in vivo Dosimetry Approach for Radiation Therapy

学术-工业合作伙伴关系将 4D 体内剂量测定方法转化为放射治疗

基本信息

批准号：
9912379
负责人：
Yong Chen
金额：
$ 45.28万
依托单位：
UNIVERSITY OF OKLAHOMA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-20 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9912379
关键词：
3-Dimensional Acoustics Animals Cancer Patient Cause of Death Clinic Clinical Computer Simulation Detection Dose Electrical Engineering Elements Ensure Feedback Frequencies Goals Image Imaging Device Imaging Techniques Intellectual Property Intensity-Modulated Radiotherapy Intervention Investigation Ions Linear Accelerator Radiotherapy Systems Location Malignant Neoplasms Maps Measurement Medical Monitor Oklahoma Outcome Patients Performance Photons Physiologic pulse Positioning Attribute Prostate Public Health Radiation Radiation Dose Unit Radiation Oncologist Radiation therapy Radiometry Recording of previous events Research Resolution Roentgen Rays Safety Shapes Signal Transduction Speed System Techniques Technology Testing Time Tissues Tomography, Computed, Scanners Toxic effect Transducers Translating Translations Ultrasonography Universities Water Work X-Ray Computed Tomography absorption base cancer radiation therapy cancer therapy clinical implementation clinical translation clinically translatable common treatment design and construction detector dose information dosimetry experience imaging capabilities imaging system improved in vivo industry partner innovation instrumentation novel product development prototype simulation soft tissue success temporal measurement tool tumor

项目摘要

The Overall Objective of this application is to enable in vivo dosimetry during radiation therapy in cancer patient to the end-user– the medical physicist. Our Hypothesis is that X-ray-induced Acoustic Computed tomography (XACT) can be used for 4D in vivo dosimetry in patients. In XACT, pulsed x-rays are absorbed and converted to heat. The resulting thermoelastic expansion generates a 3D acoustic wave, which can be detected by acoustic detectors to form images. The amplitude of the acoustic waves is proportional to X-ray absorption, and therefore encodes dose information. Our overall strategy is to design/construct a 3D XACT dosimetric scanner, and to test/refine the imaging prototype under clinical conditions based on an Academic-Industrial partnership between University of Oklahoma (OU) and PhotoSound Technologies Inc. Our specific aims are: (Specific aim 1) Evaluate the basis of the XACT imaging in radiotherapy dosimetry; (Specific aim 2) Develop a 3D XACT imaging system for clinical implementation; and (Specific aim 3) Validate the performance of XACT under clinical conditions. This discovery is the first time in history that radiation dose in tissue could be directly visualized with high spatial and temporal resolution. If successful, the ability to localize the radiation beam and map the radiation dose will enable a paradigm shift towards high-precision radiotherapy.

该应用的总体目的是在癌症患者的放射治疗过程中实现体内剂量测定法最终用户 - 医学物理学家。我们的假设是X射线引起的声学计算机断层扫描（XACT）可用于患者的4D体内剂量法。在XACT中，脉冲X射线被吸收并转换为热。所得的热弹性膨胀产生了3D声波，可以通过声学检测探测器形成图像。声波的放大器与X射线滥用成正比，因此编码剂量信息。我们的总体策略是设计/构建3D XACT剂量法扫描仪，并基于学术工业合作伙伴关系，在临床条件下测试/完善成像原型俄克拉荷马大学（OU）和Photosount Technologies Inc.我们的具体目的是：（特定目标1）评估放射疗法剂量测定中XACT成像的基础；（特定目标2）开发3D XACT 用于临床实施的成像系统；（特定目标3）验证XACT的性能临床状况。这一发现是历史上第一次直接认为组织中的辐射剂量直接用高空间和临时分辨率可视化。如果成功，则可以定位辐射束和地图辐射剂量将使范式向高精度放疗。