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Academic-Industry Partnership for the Translation of a 4D in vivo Dosimetry Approach for Radiation Therapy

学术-工业合作伙伴关系将 4D 体内剂量测定方法转化为放射治疗

基本信息

批准号：
10705086
负责人：
Yong Chen
金额：
$ 39.26万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-20 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10705086
关键词：
3-Dimensional Acoustics Animals Cancer Patient Cause of Death Clinic Clinical Computed Tomography Scanners Computer Simulation Dedications Detection Dose Electrical Engineering Elements Ensure Feedback Frequencies Goals Image Imaging Device Imaging Techniques Inpatients Intellectual Property Intensity-Modulated Radiotherapy Intervention Investigation Ions Linear Accelerator Radiotherapy Systems Location Malignant Neoplasms Maps Measurement Medical Monitor Oklahoma Outcome Patients Performance Photons Physiologic pulse Positioning Attribute Prostate Public Health Radiation Radiation Dose Unit Radiation Oncologist Radiation therapy Radiometry Recording of previous events Research Resolution Roentgen Rays Safety Shapes Signal Transduction Speed System Techniques Technology Testing Time Tissues Transducers Translating Translations Treatment-related toxicity Universities Visualization Water Work X-Ray Computed Tomography absorption cancer therapy clinical implementation clinical translation common treatment design and construction detector dose information dosimetry experience imaging capabilities imaging system improved in vivo industry partner innovation instrumentation new technology novel product development prototype simulation soft tissue success temporal measurement tool tumor ultrasound

项目摘要

The Overall Objective of this application is to enable in vivo dosimetry during radiation therapy in cancer patient to the end-user– the medical physicist. Our Hypothesis is that X-ray-induced Acoustic Computed tomography (XACT) can be used for 4D in vivo dosimetry in patients. In XACT, pulsed x-rays are absorbed and converted to heat. The resulting thermoelastic expansion generates a 3D acoustic wave, which can be detected by acoustic detectors to form images. The amplitude of the acoustic waves is proportional to X-ray absorption, and therefore encodes dose information. Our overall strategy is to design/construct a 3D XACT dosimetric scanner, and to test/refine the imaging prototype under clinical conditions based on an Academic-Industrial partnership between University of Oklahoma (OU) and PhotoSound Technologies Inc. Our specific aims are: (Specific aim 1) Evaluate the basis of the XACT imaging in radiotherapy dosimetry; (Specific aim 2) Develop a 3D XACT imaging system for clinical implementation; and (Specific aim 3) Validate the performance of XACT under clinical conditions. This discovery is the first time in history that radiation dose in tissue could be directly visualized with high spatial and temporal resolution. If successful, the ability to localize the radiation beam and map the radiation dose will enable a paradigm shift towards high-precision radiotherapy.

本应用程序的总体目标是在癌症患者放射治疗期间进行体内剂量测定到最终用户-医学物理学家。我们的假设是，X射线诱导的声学计算机断层扫描（XACT）可用于患者的4D体内剂量测定。在XACT中，脉冲X射线被吸收并转换为热所产生的热弹性膨胀产生3D声波，其可以通过声学方法检测到。探测器以形成图像。声波的振幅与X射线吸收成比例，因此编码剂量信息。我们的总体策略是设计/构建3D XACT剂量测定扫描仪，在临床条件下测试/完善成像原型，基于学术-工业合作伙伴关系，俄克拉荷马州大学（俄克拉荷马州）和PhotoSound技术公司。我们的具体目标是：（具体目标1）评价XACT成像在放射治疗剂量学中的基础;（具体目标2）开发三维XACT 用于临床实施的成像系统;以及（具体目标3）在以下条件下验证XACT的性能临床条件。这一发现是历史上第一次，组织中的辐射剂量可以直接具有高空间和时间分辨率。如果成功，定位辐射束的能力，绘制辐射剂量图将实现向高精度放射治疗的范式转变。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

X-Ray-Induced Acoustic Computed Tomography (XACT): Initial Experiment on Bone Sample.

DOI：
10.1109/tuffc.2020.3032779
发表时间：
2021-04
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
0
作者：
Robertson E;Samant P;Wang S;Tran T;Ji X;Xiang L
通讯作者：
Xiang L

Towards in vivo Dosimetry for Prostate Radiotherapy with a Transperineal Ultrasound Array: A Simulation Study.

DOI：
10.1109/trpms.2020.3015109
发表时间：
2021-05
期刊：
IEEE transactions on radiation and plasma medical sciences
影响因子：
4.4
作者：
Wang M;Samant P;Wang S;Merill J;Chen Y;Ahmad S;Li D;Xiang L
通讯作者：
Xiang L

X-ray-induced acoustic computed tomography for guiding prone stereotactic partial breast irradiation: a simulation study.

DOI：
10.1002/mp.14245
发表时间：
2020-09
期刊：
Medical physics
影响因子：
3.8
作者：
Zheng Y;Samant P;Merill J;Chen Y;Ahmad S;Li D;Xiang L
通讯作者：
Xiang L

Simulation study of protoacoustics as a real-time in-line dosimetry tool for FLASH proton therapy.

原声学作为 FLASH 质子治疗的实时在线剂量测定工具的模拟研究。

DOI：
10.1002/mp.16894
发表时间：
2023
期刊：
Medical physics
影响因子：
3.8
作者：
Kim,Kaitlyn;Pandey,PrabodhKumar;Gonzalez,Gilberto;Chen,Yong;Xiang,Liangzhong
通讯作者：
Xiang,Liangzhong

Triplex radiometric, photoacoustic, and ultrasonic imaging based on single-pulse excitation.