Conduct of studies to evaluate the toxic potential of C9-alkylbenzenes in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估 C9-烷基苯对实验动物的潜在毒性

• 批准号: 9915711
• 负责人: BARNEY SPARROW
• 金额: $ 252.02万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2020-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915711
• 关键词: Adverse effects; Chemicals; Data; Development; Ensure; Environmental Exposure; Exposure to; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Inhalation; Laboratories; Laboratory Animals; Lung; Mus; National Toxicology Program; Phase; Rattus; Risk Assessment; Risk Factors; Toxic effect; Toxicity Tests; Toxicology; Xylene; carcinogenicity; design; disorder prevention; neurobehavioral; public health research; reproductive; sound

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves characterization of the toxicity of C9-alkylbenzenes, including 1,2,4-trimethylbenzene, 2-ethyltoluene, and mixed xylenes, following exposure via whole body inhalation. Humans are likely to be similarly exposed to these compounds via inhalation. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of 1,2,4-trimethylbenzene and 2-ethyltoluene in rats and mice and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to 1,2,4-trimethylbenzene and 2-ethyltoluene. Keywords: toxicity, inhalation, trimethylbenzene, ethyltoluene, xylene, lung

该项目的目标是为国家毒理学计划(NTP)的危险识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。需要适当地进行毒理学研究，以确保结果数据是可靠的。该项目涉及通过全身吸入暴露后C9-烷基苯的毒性表征，包括1，2，4-三甲苯、2-乙基甲苯和混合二甲苯。人类很可能通过吸入类似的方式接触到这些化合物。该项目的数据将用于制定关于1，2，4-三甲苯和2-乙基甲苯对大鼠和小鼠的潜在毒性和致癌性的合理、科学的结论，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，市民亦可充分了解接触1，2，4-三甲苯和2-乙基甲苯所引致的危险因素。 关键词：毒性、吸入、三甲苯、乙基甲苯、二甲苯、肺