Social Stress Epigenetics and Cardio-Metabolic Health Among Latinos

拉丁美洲人的社会压力表观遗传学和心脏代谢健康

• 批准号: 9925830
• 负责人: Shakira Franco Suglia
• 金额: $ 67.3万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-03 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925830
• 关键词: Acceleration; Acculturation; Address; Adult; Adverse event; Affect; Age; Aging; Ancillary Study; Biological; Biological Aging; Biological Assay; Biological Markers; Biological Process; Blood specimen; Cardiovascular Diseases; Chicago; Child Abuse; Childhood; Chronic; Chronic Disease; Chronology; Cities; Communities; Country; Cross-Sectional Studies; Cuban; DNA Methylation; Data; Development; Diabetes Mellitus; Dominican; Dose; Economics; Epigenetic Process; Ethnic group; Fibrinogen; Financial Hardship; Foundations; Glucocorticoid Receptor; Health; High Prevalence; Hispanic Community Health Study/Study of Latinos; Hispanics; Hypertension; Inflammation; Intervention; Latino; Life Cycle Stages; Lipids; Longitudinal Studies; Measures; Methods; Methylation; Mexican; Minority Groups; NR3C1 gene; Not Hispanic or Latino; Obesity; Outcome; Pathway interactions; Policies; Poverty; Process; Puerto Rican; Receptor Gene; Research; Resource Allocation; Risk; Sampling; Shapes; Site; Skin; Social Network; Social support; Stress; Time; United States; Woman; Work; base; cardiometabolism; cardiovascular disorder risk; cohort; ethnic diversity; ethnic minority population; experience; genome wide methylation; genome-wide; health disparity; men; mortality; novel; racial and ethnic; racial diversity; rate of change; response; social; social culture; social stress; social stressor; socioeconomics; stressor; tool

Latinos, the largest ethnic minority group in the United States, have a high prevalence of hypertension, diabetes and obesity and also experience higher rates of poverty and social stressors in both childhood and adulthood compared to other racial/ethnic groups. There is extensive evidence that economic and social stressors shape the development of cardiometabolic health. However, it is largely unknown how these stressors affect biological processes, particularly at the cellular level. One novel method to evaluate possible mechanisms underlying the associations between social stressors and cardiometabolic health across the life course is DNA methylation (DNAm). Recently a handful of small cross-sectional studies have found that stressful experiences may alter DNAm, thus providing a potential mechanism by which social stress may get under the skin. Most of the existing health research among Latinos has been specific to Latinos of Mexican origin. Latinos are not a homogenous group and while some Latinos are at greater risk of certain chronic conditions, other Latino groups may be at lower risk for certain conditions. Examining what factors may confer risk to some Latino ethnic groups or protect other Latino ethnic groups is crucial for developing interventions and informing decisions about resource allocation. We propose to examine the association between social and economic stressors, across the life course in relation to DNAm, as well as the rate of change of methylation and changes in cardiometabolic health, using existing data from the Hispanic Community Health Study /Study of Latinos (HCHS/SOL). The HCHS/SOL study is a longitudinal study of US Latinos, representing varied countries of origin, conducted in the US. We propose to use existing data from a stratified random sample of 500 men and 500 women, who completed an extensive set of socio-economic and stress measures in the HCHS/SOL Sociocultural Ancillary study and who provided blood samples at two different time points six years apart in adulthood. Existing blood samples will be assayed for genome-wide DNAm and DNAm age. Cardiometabolic health markers (obesity, diabetes, hypertension and lipids) have also been assessed at two time points. Existing data also includes repeated assessments of social and economic stressors and socio-cultural factors (i.e., nativity, familism, acculturation, social support). Specifically, we will examine 1) whether social and economic stressors in childhood and adulthood are associated with changes in DNAm age and genome-wide methylation over a 6-year period; 2) whether sociocultural factors modify the association between stressors and changes in DNAm and 3) whether DNAm is associated with changes in cardiometabolic health over a 6-year period. Upon completion of this project, our findings will advance understanding of how social and economic stressors shape epigenetic pathways, what factors may exacerbate or ameliorate these pathways and whether epigenetic changes over time influence cardiometabolic health changes.

拉丁裔是美国最大的少数族裔，高血压患病率很高， 糖尿病和肥胖症，并且在儿童时期经历更高的贫困率和社会压力 和成年期与其他种族/族裔群体相比。有大量证据表明经济和 社会压力因素影响心脏代谢健康的发展。然而，目前尚不清楚如何 这些压力源影响生物过程，特别是在细胞水平上。一种新颖的评估方法 社会压力源与心脏代谢健康之间关联的可能机制 贯穿生命全程的是DNA甲基化（DNAm）。最近进行了一些小型横断面研究 发现压力经历可能会改变DNAm，从而提供了一种潜在的机制 社会压力可能会深入人心。大多数拉丁裔现有的健康研究都是具体的 墨西哥裔拉丁裔。拉丁裔不是一个同质群体，虽然一些拉丁裔的情况更为严重 某些慢性病的风险，其他拉丁裔群体患某些慢性病的风险可能较低。正在检查 哪些因素可能给某些拉丁裔群体带来风险或保护其他拉丁裔群体至关重要 制定干预措施并为有关资源分配的决策提供信息。我们建议审查 整个生命过程中与 DNAm 相关的社会和经济压力源之间的关联，以及 甲基化的变化率和心脏代谢健康的变化，使用现有的数据 西班牙裔社区健康研究/拉丁裔研究 (HCHS/SOL)。 HCHS/SOL 研究是一项纵向研究 在美国进行的针对代表不同原籍国的美国拉丁裔的研究。我们建议使用 现有数据来自 500 名男性和 500 名女性的分层随机样本，这些样本完成了广泛的数据集 HCHS/SOL 社会文化辅助研究中的社会经济和压力措施以及谁提供了 成年期相隔六年的两个不同时间点的血液样本。现有的血液样本将 检测全基因组 DNAm 和 DNAm 年龄。心脏代谢健康标志物（肥胖、糖尿病、 高血压和血脂）也在两个时间点进行了评估。现有数据还包括重复的 对社会和经济压力以及社会文化因素（即出生、家庭主义、 文化适应、社会支持）。具体来说，我们将研究 1) 社会和经济压力是否 儿童期和成年期与 DNAm 年龄和全基因组甲基化的变化有关 6年期限； 2）社会文化因素是否会改变压力源与变化之间的关联 DNAm 和 3) DNAm 是否与 6 年期间心脏代谢健康的变化相关。 该项目完成后，我们的研究结果将加深对社会和经济如何影响的理解 压力源塑造表观遗传途径，哪些因素可能会加剧或改善这些途径以及 表观遗传随时间的变化是否会影响心脏代谢健康的变化。