Drug use among nightclub and dance festival attendees in New York City
纽约市夜总会和舞蹈节参加者吸毒
基本信息
- 批准号:9932695
- 负责人:
- 金额:$ 3.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-30 至 2021-05-31
- 项目状态:已结题
- 来源:
- 关键词:Accident and Emergency departmentAdverse eventAffectAlcohol or Other Drugs useBathingBehavioralBiologicalBiological TestingBody partCessation of lifeCocaineComplementDancingDangerousnessDataDetectionDiffuseDrug usageDrug userElectronic MailFeedbackFentanylFestivalFundingFutureGeneral PopulationHairIllicit DrugsIndividualIngestionIntentionK2/SpiceLearningMethamphetamineMethodsModelingMolliesMotivationMusicNew York CityOpioidParticipantPatient Self-ReportPatternPercocetPersonsPharmaceutical PreparationsPilot ProjectsPoliciesPolymethyl MethacrylatePopulationPopulations at RiskPrevalencePreventionPublic HealthReportingResearchResourcesRespondentRiskRisk FactorsRisk ReductionSaltsSamplingSecureSeizuresSodium ChlorideSourceSurveysSystemTest ResultTestingTimeValidationVisitXanaxadverse outcomeanalogcathinonedrug abuse preventionecstasyepidemiology studyfollow-uphigh riskhigh risk populationinnovationnovel therapeuticsopioid misusepillpoison controlpreventresponseskillssynthetic cannabinoidtime usetrend
项目摘要
Electronic dance music (EDM) nightclub and festival attendees are at high risk for drug use and associated
adverse outcomes. EDM attendees are at high risk for using “traditional” drugs such as ecstasy (MDMA,
“Molly”), but they are also now at high risk for use of new psychoactive substances (NPS), which are a major
new drug-related public health threat. NPS are often adulterants in or replacements for “traditional” illicit drugs
such as ecstasy; thus, many users unknowingly ingest such new and dangerous substances. Ecstasy, for
example, is often adulterated or replaced with NPS such as synthetic cathinones (“bath salts”) and the PI and
his colleagues have detected highly potent drugs (e.g., alpha-PVP, PMMA, methamphetamine) in ecstasy
users' hair despite them denying use of these drugs. Thus, ecstasy use appears to be a major delivery system
of unintentional NPS use. Fentanyl and other dangerous opioid NPS are also now being detected in cocaine
and in pills resembling Xanax and Percocet. Drug-related deaths at EDM festivals have become common, and
with the popularity of EDM parties increasing, it is essential to focus on intentional and unintentional drug use
in this at-risk population in order to prevent use, poisonings, and deaths. We have developed and validated a
rapid survey (via the PI's K01) to query use of dozens of common drugs and >100 NPS in the EDM scene and
we have validated hair testing methods to determine use of >100 NPS and >15 common drugs. Such biological
testing can help us estimate the true prevalence of use of NPS and other drugs (e.g., ecstasy) in these high-
risk nightlife scenes. The objective of this study is to systematically examine the prevalence of known and
unknown drug use, risk factors for use, self-reported adverse outcomes associated with use, and trends in use
and adverse outcomes over 24 months. Since many individuals unknowingly use NPS, it is essential to
validate survey responses. This study is innovative as we will test hair of participants to validate responses and
also determine the extent of unintentional use of NPS and other drugs. Hair testing is an ideal biological testing
method because we are able to detect the presence of >100 NPS (including fentanyl and 15 of its analogues)
in hair for >12 months post-use. Our validated rapid survey complemented with hair testing (for validation) will
allow us to estimate the prevalence of drug use in the nightclub and festival scenes in NYC. Using time-space
sampling, we will randomly select EDM parties throughout NYC, and survey 2,080 individuals entering these
parties (biweekly). An exploratory longitudinal component will also help us determine whether providing a
subsample of participants with feedback regarding their hair testing results influences drug use and intention to
use over time (6 months post-survey). Estimating intentional and unintentional drug use and adverse
consequences associated with use may allow us to detect some risky drug trends (e.g., use of [adulterated]
ecstasy) before diffusing to the general public. Methods will be generalizable to other at-risk populations and
results will inform prevention information to be disseminated to the public and to those at highest risk.
电子舞曲(EDM)夜总会和音乐节的参与者是吸毒和相关的高风险
不良后果。EDM与会者使用“传统”毒品的风险很高,如摇头丸(MDMA,
“莫莉”),但他们现在也处于使用新精神活性物质(NAPs)的高风险之中,这是一个主要的
与毒品有关的新的公共卫生威胁。毒品往往是“传统”非法药物的掺杂物或替代品
例如摇头丸;因此,许多使用者在不知情的情况下摄入了这种新的危险物质。兴奋,因为
例如,经常掺杂或用诸如合成卡西酮(“浴盐”)和PI等的香料替代,
他的同事已经检测到高效药物(例如,alpha-PVP、PMMA、甲基苯丙胺)
使用者的头发,尽管他们否认使用这些药物。因此,摇头丸的使用似乎是一种主要的输送系统,
无意的骚扰。芬太尼和其他危险的阿片类药物现在也在可卡因中被发现
还有类似阿普唑仑和扑热息痛的药片在EDM节日期间与毒品有关的死亡已经变得普遍,
随着EDM派对的日益流行,必须关注有意和无意的药物使用
以防止使用、中毒和死亡。我们已经开发并验证了
快速调查(通过PI的K 01),以查询EDM场景中数十种常见药物和>100种药物的使用情况,
我们已经验证了头发测试方法,以确定>100毫克和>15种常见药物的使用。此类生物
测试可以帮助我们估计使用抗抑郁药和其他药物的真实流行率(例如,在这些高-
冒险夜生活场景。本研究的目的是系统地检查已知和
未知药物使用、使用风险因素、与使用相关的自我报告不良结局和使用趋势
以及24个月内的不良后果。由于许多人在不知不觉中使用了cookies,因此必须
验证调查答复。这项研究是创新的,因为我们将测试参与者的头发,以验证反应,
还确定非故意使用海洛因和其他毒品的程度。毛发检测是一种理想的生物检测方法
方法,因为我们能够检测到>100 μ g的存在(包括芬太尼及其15种类似物)
在头发上使用>12个月。我们经过验证的快速调查补充头发测试(验证)将
让我们来估计毒品使用的流行在夜总会和节日现场在纽约市。利用时空
抽样,我们将随机选择EDM党在纽约市,并调查2,080人进入这些
聚会(每两周一次)。一个探索性的纵向组成部分也将帮助我们确定是否提供一个
参与者的子样本与他们的头发测试结果的反馈影响药物使用和意图,
随时间推移使用(调查后6个月)。估计故意和无意吸毒以及
与使用相关联的后果可以允许我们检测一些危险的药物趋势(例如,使用[掺假]
摇头丸),然后扩散到一般公众。方法将推广到其他高危人群,
评估结果将为向公众和高危人群传播预防信息提供依据。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Joseph J Palamar其他文献
Challenging the Continued Usefulness of Social Media Recruitment for Surveys of Hidden Populations of People Who Use Opioids
挑战社交媒体招募对使用阿片类药物的隐性人群调查的持续有用性
- DOI:
10.2196/63687 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:6.000
- 作者:
Elizabeth D Nesoff;Joseph J Palamar;Qingyue Li;Wenqian Li;Silvia S Martins - 通讯作者:
Silvia S Martins
Joseph J Palamar的其他文献
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{{ truncateString('Joseph J Palamar', 18)}}的其他基金
New psychoactive substance exposure among NYC nightclub and festival attendees
纽约夜总会和节日参加者接触新的精神活性物质
- 批准号:
10734617 - 财政年份:2023
- 资助金额:
$ 3.51万 - 项目类别:
Drug use among nightclub and dance festival attendees in New York City
纽约市夜总会和舞蹈节参加者吸毒
- 批准号:
9788383 - 财政年份:2018
- 资助金额:
$ 3.51万 - 项目类别:
Drug use among nightclub and dance festival attendees in New York City
纽约市夜总会和舞蹈节参加者吸毒
- 批准号:
10400438 - 财政年份:2018
- 资助金额:
$ 3.51万 - 项目类别:
Development of a Rapid Survey to Detect Use of New and Emerging Drugs
开展快速调查以检测新药和新兴药物的使用情况
- 批准号:
9220804 - 财政年份:2015
- 资助金额:
$ 3.51万 - 项目类别:
Development of a Rapid Survey to Detect Use of New and Emerging Drugs
开展快速调查以检测新药和新兴药物的使用情况
- 批准号:
9004616 - 财政年份:2015
- 资助金额:
$ 3.51万 - 项目类别:
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