Dementia Risk and Dynamic Response to Exercise

痴呆症风险和运动的动态反应

基本信息

  • 批准号:
    9977080
  • 负责人:
  • 金额:
    $ 15.3万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-07-15 至 2022-04-30
  • 项目状态:
    已结题

项目摘要

Abstract The brain and cardiovascular system share common risk factors for age-related diseases such as hypertension, hypercholesterolemia, and genetics (e.g. APOE4). Because of this link, much work has focused on the role of cerebrovascular health in reducing dementia risk. Regular aerobic exercise has well-established benefits for cardiovascular health and has been repeatedly linked to better cognition, brain health, and lower risk of dementia. Despite strong evidence for sustained cognitive and brain outcomes, the mechanisms relating aerobic exercise with brain health and cognition remain imprecisely defined. Amongst many potential mechanisms, cerebral blood flow (CBF) and blood-based biomarkers, such as neurotrophins, are promising targets for their shared association to brain and cardiovascular health. Prior investigations have largely attempted to measure change in these mechanisms under resting conditions after an extended exercise intervention with mixed and conflicting results. Further, studies have often not accounted for genetic differences that may blunt the effect of exercise. Unlike prior work, our innovative approach is to begin by characterizing the dynamic changes that result from an acute exercise challenge. A single bout of aerobic exercise temporarily increases cerebral blood flow (CBF) and prompts neurotrophin release. These transient changes ultimately drive long-term physiologic adaptation to exercise. Therefore, we will characterize the dynamic response to an acute, standardized bout of aerobic exercise in a group of nondemented older adults, comparing those who do and do not carry the APOE4 allele. The first aim will test if CBF response to an acute exercise challenge is blunted in APOE4 carriers. The second aim will similarly test the acute exercise response of blood-based biomarkers such as brain derived neurotrophic factor, insulin-like growth factor, and vascular endothelial growth factor in APOE4 carriers versus non-carriers. Finally, we will explore the relationship of acute changes in CBF with our blood-based biomarkers and cognitive performance. We expect that more accurately understanding the acute effects will provide valuable insight into how aerobic exercise supports cognitive function and brain health. Armed with this knowledge we can optimize biomarker measurement for future exercise intervention randomized controlled trials, informing our long-term goal of identifying precision exercise prescription for AD prevention.
摘要 大脑和心血管系统具有与年龄相关的疾病的共同风险因素,例如 高血压、高胆固醇血症和遗传学(例如APOE 4)。由于这种联系,许多工作都集中在 脑血管健康在降低痴呆风险中的作用。有规律的有氧运动 有益于心血管健康,并一再与更好的认知,大脑健康和降低 痴呆症的风险。尽管有强有力的证据表明持续的认知和大脑结果, 有氧运动与大脑健康和认知的关系仍不明确。在许多潜在的 机制,脑血流量(CBF)和基于血液的生物标志物,如神经营养因子,是有希望的, 目标是它们与大脑和心血管健康的共同关联。此前的调查主要是 试图测量在长时间运动后静息状态下这些机制的变化 干预的结果喜忧参半。此外,研究往往没有考虑到遗传因素, 这些差异可能会削弱锻炼的效果。与以前的工作不同,我们的创新方法是开始, 表征由急性运动挑战引起的动态变化。一次有氧运动 运动暂时增加脑血流量(CBF)并促进神经营养素释放。这些瞬态 这些变化最终促使人们对运动产生长期的生理适应。因此,我们将描述 一组非痴呆老年人对急性标准化有氧运动的动态反应, 比较携带和不携带APOE4等位基因的人。第一个目标是测试CBF是否对急性脑梗死的反应。 APOE 4携带者的运动挑战变得迟钝。第二个目标将类似地测试急性运动反应 基于血液的生物标志物,如脑源性神经营养因子、胰岛素样生长因子和血管内皮生长因子, APOE4携带者与非携带者的内皮生长因子。最后,我们将探讨 CBF的急性变化与我们的血液生物标志物和认知能力。我们期待更多 准确地理解急性效应将提供有价值的见解如何有氧运动支持 认知功能和大脑健康。有了这些知识,我们可以优化生物标志物测量, 未来的运动干预随机对照试验,告知我们的长期目标, 预防AD的运动处方。

项目成果

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Eric Dennis Vidoni其他文献

Eric Dennis Vidoni的其他文献

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{{ truncateString('Eric Dennis Vidoni', 18)}}的其他基金

Core E: Outreach, Recruitment and Engagement Core
核心 E:外展、招聘和参与核心
  • 批准号:
    10264627
  • 财政年份:
    2021
  • 资助金额:
    $ 15.3万
  • 项目类别:
Core G: Research Education Component
核心 G:研究教育部分
  • 批准号:
    10264630
  • 财政年份:
    2021
  • 资助金额:
    $ 15.3万
  • 项目类别:
Core E: Outreach, Recruitment and Education Core
核心 E:外展、招聘和教育核心
  • 批准号:
    9172554
  • 财政年份:
  • 资助金额:
    $ 15.3万
  • 项目类别:
Core E: Outreach, Recruitment and Education Core
核心 E:外展、招聘和教育核心
  • 批准号:
    9978597
  • 财政年份:
  • 资助金额:
    $ 15.3万
  • 项目类别:
Core E: Outreach, Recruitment and Education Core
核心 E:外展、招聘和教育核心
  • 批准号:
    9753824
  • 财政年份:
  • 资助金额:
    $ 15.3万
  • 项目类别:

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