Biostatistics, Epidemiology, and Research Design Core

生物统计学、流行病学和研究设计核心

基本信息

批准号：
9979932
负责人：
Julie A Stoner
金额：
$ 65.99万
依托单位：
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9979932
关键词：
Address Adoption American Indians Applications Grants Area Basic Science Biometry Biostatistical Methods Clinical Clinical Research Clinical Sciences Communities Computerized Medical Record Consult Consultations Data Data Collection Data Reporting Data Set Data Sources Databases Degree program Development Diagnostic Procedure Discipline Disease Educational workshop Effectiveness Ensure Epidemiologic Methods Epidemiologic Research Design Epidemiology Extramural Activities Faculty Funding Grant Health Health Professional Health system Infrastructure Institution Laboratory Research Master of Science Measurement Medical Methodology Methods Mission Oklahoma Patients Peer Review Personal Satisfaction Population Population Surveillance Prevention strategy Process Productivity Publications Qualitative Research Quality Control Randomized Controlled Clinical Trials Recommendation Registries Reporting Reproducibility Research Research Design Research Infrastructure Research Methodology Research Personnel Research Project Grants Research Support Resources Risk Factors Sample Size Science Secure Source Statistical Methods Students Surveys System Therapeutic Intervention Training Translational Research Tribes Work analytical method base clinical care clinical data warehouse cohort community based participatory research data quality data warehouse design epidemiology study health assessment health organization implementation research improved innovation instrument intervention program lectures member novel novel strategies population health preclinical study programs research study secondary analysis skills success surveillance data translational study treatment strategy

项目摘要

Effective clinical and translational research requires rigorous study designs, appropriate application of analytic methods, and careful reporting. The Biostatistics, Epidemiology, and Research Design (BERD) has been instrumental in expanding clinical and translational research of new investigators, community partners, and programs of the OSCTR, supporting over 470 research projects, resulting in 72 peer-reviewed publications and 112 grant applications (78 extramural and 34 intramural applications). The BERD has enhanced research methods training (130 seminars/lectures, supporting 25 MS in Clinical and Translational Science thesis projects), expanded the use of novel analytic methods and research designs (31 publications, 48 seminars, five workshops, and two grant-funded projects), and expanded research infrastructure through the deployment of a survey calling center and enhanced REDCap infrastructure, growing use from 6 projects/year to 207 projects in 2016. The revised mission of the BERD Core is to enable OSCTR investigators and partner institutions to design, perform, and report rigorous, reproducible, and innovative studies that can be applied to improve clinical care and patient well-being in Oklahoma and other IDeA states. To do this, the BERD Core provides consultative expertise in biostatistics, epidemiology, and qualitative research methods (Aim 1); coordinates a new, unique and robust data repository infrastructure and analytic skill set for clinical epidemiologic studies (Aim 2); and develops and applies novel research designs and analytic methods focused on the needs of OSCTR research (Aim 3). BERD Core members collaborate with investigators to address sources of bias, identify sufficient sample sizes, select measurement instruments, perform data quality control, manage and analyze data, and report study results. The BERD Core works with the Professional Development Core to develop workshops on research methods, and with the Administrative Core to produce training videos, templates, and fact sheets for the portal. A new BERD initiative with this renewal, the Clinical Data Warehouse, leverages a unique resource developed at OUHSC to make de-identified electronic medical records available for research to enhance the capacity for clinical epidemiologic and population health research in Oklahoma. The BERD Core helps investigators identify appropriate data sources and variables to address their research questions, then uses the Clinical Data Warehouse validated process to generate a project dataset. Finally, to advance biostatistics and epidemiologic methods, the BERD Core holds monthly seminars to disseminate novel research designs, analysis methods, and research findings. The BERD Core performs methodological research to adapt existing methods or develop new approaches to address research questions, for example, developing new statistical methods to reduce bias and increase estimation efficiency in small populations, such as American Indian tribes. Together, these activities of the BERD Core enable OSCTR investigators to perform rigorous, reproducible, and innovative research to better understand and address health needs in Oklahoma.

有效的临床和转化研究需要严格的研究设计，适当应用分析方法和仔细的报告。生物统计学，流行病学和研究设计（BERD）一直是有助于扩大新研究人员，社区合作伙伴以及 OSCTR的计划，支持470多个研究项目，从而有72个同行评审的出版物和 112赠款申请（78个壁外和34个壁内申请）。 Berd增强了研究方法培训（130次研讨会/讲座，支持临床和转化科学论文25 ms 项目），扩大了新颖的分析方法和研究设计的使用（31个出版物，48个研讨会，五个研讨会和两个赠款资助的项目），并通过部署扩大了研究基础设施调查中心和增强REDCAP基础设施的调查，从6个项目增加到207 2016年的项目。BERD核心的修订使命是启用OSCTR调查人员和合作伙伴设计，执行和报告严格，可重现和创新研究的机构，可以应用于改善俄克拉荷马州和其他想法状态的临床护理和患者福祉。为此，Berd Core 提供生物统计学，流行病学和定性研究方法方面的咨询专业知识（AIM 1）；协调一个新的，独特而健壮的数据存储库基础架构和分析技能，用于临床流行病学研究（AIM 2）；并开发和应用新颖的研究设计和集中的分析方法关于OSCTR研究的需求（AIM 3）。 BERD核心成员与调查人员合作解决偏见的来源，确定足够的样本量，选择测量工具，执行数据质量控制，管理和分析数据，并报告研究结果。 BERD核心与专业发展合作核心开展有关研究方法的研讨会，并使用行政核心来制作培训视频，模板和门户的事实表。该续约，临床数据仓库的一项新的BERD倡议，利用OUHSC开发的一种独特的资源，以使已识别的电子病历可用为了提高俄克拉荷马州临床流行病学和人口健康研究的能力。 BERD核心帮助调查人员确定适当的数据源和变量以解决他们的研究问题，然后使用临床数据仓库验证的流程来生成项目数据集。最后，到提前生物统计学和流行病学方法，BERD核心举行每月研讨会以传播新颖的研究设计，分析方法和研究结果。 BERD核心执行方法论研究适应现有方法或开发新方法以解决研究问题，例如开发新的统计方法来降低偏见并提高小种群的估计效率，例如作为美洲印第安部落。 BERD核心的这些活动共同使OSCTR研究人员能够执行严格，可重现和创新的研究，以更好地理解和满足俄克拉荷马州的健康需求。